Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells. (Q42001195)

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scientific article published on 11 June 2013

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English	Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells.	scientific article published on 11 June 2013

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3 March 2020

Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells (English)

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angiogenesis inhibitor

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Sara Carbajo-Pescador

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José L. Mauriz

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Javier González-Gallego

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R Ordoñez

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M Benet

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A García-Palomo

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British Journal of Cancer

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83-91

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Antiangiogenic effects of melatonin in endothelial cell cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708553

5 June 2018

Melatonin induces transcriptional regulation of Bim by FoxO3a in HepG2 cells

1 reference

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5 June 2018

Peroxiredoxin 1 stimulates endothelial cell expression of VEGF via TLR4 dependent activation of HIF-1α.

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5 June 2018

VEGF in tumor progression and targeted therapy

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5 June 2018

Regulation of vascular endothelial growth factor by melatonin in human breast cancer cells

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Endothelial precursor cells promote angiogenesis in hepatocellular carcinoma

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Melatonin suppresses tumor progression by reducing angiogenesis stimulated by HIF-1 in a mouse tumor model

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Clinical implications of cancer stem cell biology in hepatocellular carcinoma

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5 June 2018

STAT3 inhibition, a novel approach to enhancing targeted therapy in human cancers (review).

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5 June 2018

Hepatocellular Carcinoma: Important Biomarkers and their Significance in Molecular Diagnostics and Therapy

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5 June 2018

Melatonin sensitizes human hepatoma cells to endoplasmic reticulum stress–induced apoptosis

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5 June 2018

Expression characteristics of HIF-1α and its clinical values in diagnosis and prognosis of hepatocellular carcinoma

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5 June 2018

A novel regulation of VEGF expression by HIF‐1α and STAT3 in HDM2 transfected prostate cancer cells

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5 June 2018

Melatonin prevents human pancreatic carcinoma cell PANC-1-induced human umbilical vein endothelial cell proliferation and migration by inhibiting vascular endothelial growth factor expression

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5 June 2018

Suppression of STAT3 and HIF-1 Alpha Mediates Anti-Angiogenic Activity of Betulinic Acid in Hypoxic PC-3 Prostate Cancer Cells

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5 June 2018

Melatonin modulation of intracellular signaling pathways in hepatocarcinoma HepG2 cell line: role of the MT1 receptor.

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5 June 2018

Sphingosine kinase 1 pathway is involved in melatonin-induced HIF-1α inactivation in hypoxic PC-3 prostate cancer cells

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5 June 2018

Hallmarks of Cancer: The Next Generation

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5 June 2018

Melatonin reduces pancreatic tumor cell viability by altering mitochondrial physiology

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5 June 2018

CCAAT/enhancer-binding protein alpha (C/EBPalpha) and hepatocyte nuclear factor 4alpha (HNF4alpha) synergistically cooperate with constitutive androstane receptor to transactivate the human cytochrome P450 2B6 (CYP2B6) gene: application to the devel

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5 June 2018

Melatonin decreases cell proliferation and induces melanogenesis in human melanoma SK-MEL-1 cells

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Melatonin suppresses tumor angiogenesis by inhibiting HIF-1alpha stabilization under hypoxia

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5 June 2018

p38 MAPK and NF-kappaB pathways are involved in naphtho[1,2-b] furan-4,5-dione induced anti-proliferation and apoptosis of human hepatoma cells

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5 June 2018

miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells.

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5 June 2018

Changes in the expression of melatonin receptors induced by melatonin treatment in hepatocarcinoma HepG2 cells.

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5 June 2018

Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line

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Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells

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Melatonin modulates the expression of VEGF and HIF-1 alpha induced by CoCl2 in cultured cancer cells

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Hypoxia and hepatocellular carcinoma: The therapeutic target for hepatocellular carcinoma

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Caffeic acid and its synthetic derivative CADPE suppress tumor angiogenesis by blocking STAT3-mediated VEGF expression in human renal carcinoma cells

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The role of VEGF and EGFR inhibition: implications for combining anti-VEGF and anti-EGFR agents.

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Melatonin induces apoptosis in human neuroblastoma cancer cells.

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Antiproliferative activity of melatonin by transcriptional inhibition of cyclin D1 expression: a molecular basis for melatonin-induced oncostatic effects.

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HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas.

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Is there a role for melatonin in supportive care?

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Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture

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Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture

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10.1038/BJC.2013.285

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