Regulation of hepcidin expression by inflammation-induced activin B. (Q41961541)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27922109 AND SRC:MED&resulttype=core&format=json

29 March 2020

title

Regulation of hepcidin expression by inflammation-induced activin B (English)

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29 March 2020

6

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29 March 2020

Makoto Sugiyama

2

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29 March 2020

author name string

Yohei Kanamori

1

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29 March 2020

Osamu Hashimoto

3

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29 March 2020

Masaru Murakami

4

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29 March 2020

Tohru Matsui

5

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29 March 2020

language of work or name

English

0 references

publication date

6 December 2016

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29 March 2020

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29 March 2020

volume

6

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29 March 2020

page(s)

38702

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Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.

29 March 2020

cites work

1 reference

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Role of a TPA-responsive element in hepcidin transcription induced by the bone morphogenetic protein pathway

5 June 2018

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Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation

5 June 2018

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IL-6 in inflammation, immunity, and disease

5 June 2018

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The regulation of hepcidin expression by serum treatment: requirements of the BMP response element and STAT- and AP-1-binding sites.

5 June 2018

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The liver: conductor of systemic iron balance

5 June 2018

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Systemic iron homeostasis

5 June 2018

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A new class of small molecule inhibitor of BMP signaling

5 June 2018

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TGFβ signalling in context

5 June 2018

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5 June 2018

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The specificities of small molecule inhibitors of the TGFß and BMP pathways

5 June 2018

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Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats

5 June 2018

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Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation

5 June 2018

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Role of endogenous TGF‐β family in myogenic differentiation of C2C12 cells

5 June 2018

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The challenge of developing novel pharmacological therapies for non-alcoholic steatohepatitis

5 June 2018

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Two to tango: regulation of Mammalian iron metabolism

5 June 2018

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Bone morphogenetic protein receptors and signal transduction

5 June 2018

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Receptor expression modulates the specificity of transforming growth factor-beta signaling pathways

5 June 2018

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BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

5 June 2018

1 reference

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Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5138601

TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch

5 June 2018

1 reference

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BMP type I receptor inhibition reduces heterotopic [corrected] ossification

5 June 2018

1 reference

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Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5138601

Transforming growth factor beta-induced Smad1/5 phosphorylation in epithelial cells is mediated by novel receptor complexes and is essential for anchorage-independent growth

5 June 2018

1 reference

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Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5138601

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5138601

Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia

5 June 2018

1 reference

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Activin B can signal through both ALK4 and ALK7 in gonadotrope cells

5 June 2018

1 reference

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STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

5 June 2018

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Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6

5 June 2018

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Characterization of isoforms of activin receptor-interacting protein 2 that augment activin signaling

5 June 2018

1 reference

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Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

5 June 2018

1 reference

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Activin isoforms signal through type I receptor serine/threonine kinase ALK7

5 June 2018

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The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes

5 June 2018

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Receptor internalization-independent activation of Smad2 in activin signaling

5 June 2018

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Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling

5 June 2018

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Id: a target of BMP signaling

5 June 2018

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cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)

5 June 2018

1 reference

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Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter

5 June 2018

1 reference

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Synergistic effects of different bone morphogenetic protein type I receptors on alkaline phosphatase induction

5 June 2018

1 reference

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A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5138601

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

5 June 2018

1 reference

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5 June 2018

The biology of PECAM-1.

1 reference

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Formation and activation by phosphorylation of activin receptor complexes

5 June 2018

1 reference

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Activin as autocrine and paracrine factor in the ovary

5 June 2018

1 reference

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F4/80, a monoclonal antibody directed specifically against the mouse macrophage

5 June 2018

1 reference

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Mechanism of Cycloheximide Inhibition of Protein Synthesis in a Cell-free System Prepared from Rat Liver

5 June 2018

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Isolation and partial characterization of a Mr 32,000 protein with inhibin activity from porcine follicular fluid

5 June 2018

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Pituitary FSH is released by a heterodimer of the beta-subunits from the two forms of inhibin.

5 June 2018

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Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid

5 June 2018

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Isolation and characterization of native activin B

5 June 2018

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Diet-induced changes in Ucp1 expression in bovine adipose tissues.

5 June 2018

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Expression of activin receptor-like kinase 7 in adipose tissues

18 August 2018

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Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling

18 August 2018

1 reference

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Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor beta actions in hepatocytes--but without modulating bone morphogenetic protein 7 signaling

18 August 2018

1 reference

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Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors

18 August 2018

1 reference

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Intracrine signalling of activin A in hepatocytes upregulates connective tissue growth factor (CTGF/CCN2) expression

18 August 2018

1 reference

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The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5138601

Presenilin-1 detection in brain neurons and FOXp3 in peripheral blood mononuclear cells: normalizer gene selection for real time reverse transcriptase pcr using the DeltaDeltaCt method

18 August 2018

1 reference

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Molecular weight forms of inhibin a and inhibin B in the bovine testis change with age.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5138601

Alterations in peripheral concentrations of inhibin A in cattle studied using a time-resolved immunofluorometric assay: relationship with estradiol and follicle-stimulating hormone in various reproductive conditions

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5138601

Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia

18 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27922109

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A sensitive detection of phospho-Smad1/5/8 and Smad2 in Western blot analyses

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27922109

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SREP38702

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27922109 AND SRC:MED&resulttype=core&format=json

29 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27922109 AND SRC:MED&resulttype=core&format=json

29 March 2020

PubMed publication ID

27922109

1 reference