Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity (Q41933022)

14 October 2017

title

Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity (English)

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14 October 2017

3

Marcin Drag

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14 October 2017

Marcin Poreba

1

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14 October 2017

Guy S Salvesen

series ordinal

2

1 reference

14 October 2017

publication date

21 September 2017

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14 October 2017

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14 October 2017

volume

12

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14 October 2017

issue

10

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14 October 2017

page(s)

2189-2214

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Emerging principles in protease-based drug discovery

14 October 2017

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A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

21 January 2018

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Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries

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Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways.

21 January 2018

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Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities

21 January 2018

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Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes).

21 January 2018

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Irreversible inhibitors of serine, cysteine, and threonine proteases

21 January 2018

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Labeling of active proteases in fresh-frozen tissues by topical application of quenched activity-based probes

21 January 2018

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Design of a highly selective quenched activity-based probe and its application in dual color imaging studies of cathepsin S activity localization

21 January 2018

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Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling

21 January 2018

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Current and prospective applications of non-proteinogenic amino acids in profiling of proteases substrate specificity

21 January 2018

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A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)

21 January 2018

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Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates

21 January 2018

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Peptide libraries: determination of relative reaction rates of protected amino acids in competitive couplings

21 January 2018

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Caspases: keys in the ignition of cell death

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Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions

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Structure and function of legumain in health and disease

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Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes

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Extended substrate specificity and first potent irreversible inhibitor/activity-based probe design for Zika virus NS2B-NS3 protease

21 January 2018

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Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4

21 January 2018

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Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis.

21 January 2018

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Positional scanning synthetic combinatorial libraries for substrate profiling

21 January 2018

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The elastase-PK101 structure: mechanism of an ultrasensitive activity-based probe revealed

21 January 2018

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Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface

21 January 2018

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Ultrasensitive internally quenched substrates of human cathepsin L.

21 January 2018

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Functional phenotyping of human plasma using a 361-fluorogenic substrate biosensing microarray.

21 January 2018

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Current trends and challenges in proteomic identification of protease substrates.

21 January 2018

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Proteomic discovery of protease substrates

21 January 2018

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Selecting protein N-terminal peptides by combined fractional diagonal chromatography

21 January 2018

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Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases

21 January 2018

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Caspase-10 in mouse or not?

21 January 2018

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https://api.crossref.org/works/10.1038/NPROT.2017.091

Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2017.091

Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors

21 January 2018

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https://api.crossref.org/works/10.1038/NPROT.2017.091

Activity profiling of aminopeptidases in cell lysates using a fluorogenic substrate library.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2017.091

Unnatural amino acids increase activity and specificity of synthetic substrates for human and malarial cathepsin C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2017.091

Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2017.091

Barrel-shaped ClpP Proteases Display Attenuated Cleavage Specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2017.091

Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2017.091

Substrate activity screening (SAS): a general procedure for the preparation and screening of a fragment-based non-peptidic protease substrate library for inhibitor discovery

21 January 2018

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https://api.crossref.org/works/10.1038/NPROT.2017.091

On the evolution of the standard amino-acid alphabet

21 January 2018

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https://api.crossref.org/works/10.1038/NPROT.2017.091

Amino acid-protecting groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2017.091

Activity-based probes that target diverse cysteine protease families

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2017.091

An optimized activity-based probe for the study of caspase-6 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2017.091

Activity-based profiling of proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2017.091

Caspases: preparation and characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2017.091

Activation and specificity of human caspase-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2017.091

Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2017.091

Activation of caspases-8 and -10 by FLIP(L).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2017.091

A unified model for apical caspase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2017.091

Tools for investigating peptide-protein interactions: peptide incorporation of environment-sensitive fluorophores through SPPS-based 'building block' approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2017.091

The mechanism of peptide-binding specificity of IAP BIR domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2017.091

Positional scanning substrate combinatorial library (PS-SCL) approach to define caspase substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2017.091

Recent advances and concepts in substrate specificity determination of proteases using tailored libraries of fluorogenic substrates with unnatural amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/NPROT.2017.091

Commonly used caspase inhibitors designed based on substrate specificity profiles lack selectivity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NPROT.2017.091

Subsite cooperativity in protease specificity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NPROT.2017.091

Human neutrophil elastase phosphonic inhibitors with improved potency of action

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NPROT.2017.091

31 March 2020

Identifiers

DOI

10.1038/NPROT.2017.091

1 reference

14 October 2017

1 reference