Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation (Q41886769)

13 October 2017

Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation (English)

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13 October 2017

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13 October 2017

11

Mark T Gladwin

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13 October 2017

13

Malte Kelm

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13 October 2017

Anja Kipar

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Andrew R. Cossins

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Andrew R Cossins

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Heinz-Jürgen Steinhoff

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Heinz-Juergen Steinhoff

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Ulrike B Hendgen-Cotta

2

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Ulrike B Hendgen-Cotta

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13 October 2017

15

Tienush Rassaf

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13 October 2017

Matthias Totzeck

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13 October 2017

Peter Luedike

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13 October 2017

Michael Berenbrink

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13 October 2017

Dominik Semmler

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13 October 2017

Sruti Shiva

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13 October 2017

Daryl Williams

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13 October 2017

Juergen Schrader

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13 October 2017

language of work or name

English

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publication date

9 June 2012

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13 October 2017

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126

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325-334

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Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats

13 October 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Human neuroglobin functions as a redox-regulated nitrite reductase

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

The role of vascular myoglobin in nitrite-mediated blood vessel relaxation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Nitrite potently inhibits hypoxic and inflammatory pulmonary arterial hypertension and smooth muscle proliferation via xanthine oxidoreductase-dependent nitric oxide generation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Nitrite therapy after cardiac arrest reduces reactive oxygen species generation, improves cardiac and neurological function, and enhances survival via reversible inhibition of mitochondrial complex I.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Nitrite directly vasodilates hypoxic vasculature via nitric oxide-dependent and -independent pathways

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Cytoglobin is expressed in the vasculature and regulates cell respiration and proliferation via nitric oxide dioxygenation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Nitrite reductase activity of cytochrome c

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

The functional nitrite reductase activity of the heme-globins

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Nitric oxide synthase reduces nitrite to NO under anoxia

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Hypoxia-inducible myoglobin expression in nonmuscle tissues

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Chemical nature of nitric oxide storage forms in rat vascular tissue.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

K(ATP)( ) channels, nitric oxide, and adenosine are not required for local metabolic coronary vasodilation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Effects of pH on vascular tension: which are the important mechanisms?

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

The L-arginine-nitric oxide pathway

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Canine coronary vasodepressor responses to hypoxia are abolished by 8-phenyltheophylline.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Different Mechanisms of Hypoxic Relaxation in Canine Coronary Arteries and Rat Abdominal Aortas

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Nitric oxide stimulates myoglobin gene and protein expression in vascular smooth muscle.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Diverse cell-specific expression of myoglobin isoforms in brain, kidney, gill and liver of the hypoxia-tolerant carp and zebrafish

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Nitrite infusion in humans and nonhuman primates: endocrine effects, pharmacokinetics, and tolerance formation

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Effects of dietary nitrate on blood pressure in healthy volunteers.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Contribution of prostaglandins in hypoxia-induced vasodilation in isolated rabbit hearts. Relation to adenosine and KATP channels.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410747

Hypoxic vasodilatation in isolated, perfused guinea-pig heart: an analysis of the underlying mechanisms

18 August 2018

1 reference

12 December 2020

Hypoxia-induced change in prostanoids production and coronary flow in isolated rat heart

1 reference

12 December 2020

Mitochondrial cytochrome oxidase produces nitric oxide under hypoxic conditions: implications for oxygen sensing and hypoxic signaling in eukaryotes

1 reference

12 December 2020

Enzyme-independent formation of nitric oxide in biological tissues

1 reference

12 December 2020

Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration

1 reference

12 December 2020

Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation

1 reference

12 December 2020

Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs

1 reference

12 December 2020

Nitrite reductase function of deoxymyoglobin: oxygen sensor and regulator of cardiac energetics and function

1 reference

12 December 2020

The role of prostaglandins in the endothelium-mediated vasodilatory response to hypoxia

1 reference

12 December 2020

Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites

1 reference

12 December 2020

Hypoxic Modulation of Exogenous Nitrite-Induced Vasodilation in Humans

1 reference

12 December 2020

Acidosis-induced coronary arteriolar dilation is mediated by ATP-sensitive potassium channels in vascular smooth muscle

1 reference

12 December 2020

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates

1 reference

12 December 2020

Nitrite-dependent vasodilation is facilitated by hypoxia and is independent of known NO-generating nitrite reductase activities

1 reference

12 December 2020

Hemoglobin oxygen fractional saturation regulates nitrite-dependent vasodilation of aortic ring bioassays

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12 December 2020

10.1161/CIRCULATIONAHA.111.087155

Identifiers

DOI

1 reference

13 October 2017

1 reference

13 October 2017

PubMed publication ID

22685116

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