Mucosal Adjuvanticity and Immunogenicity of LTR72, a Novel Mutant of Escherichia coli Heat-labile Enterotoxin with Partial Knockout of ADP-ribosyltransferase Activity (Q41855397)

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scientific article published on April 6, 1998

Language	Label	Description	Also known as
English	Mucosal Adjuvanticity and Immunogenicity of LTR72, a Novel Mutant of Escherichia coli Heat-labile Enterotoxin with Partial Knockout of ADP-ribosyltransferase Activity	scientific article published on April 6, 1998

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scholarly article

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Europe PubMed Central

PMC publication ID

13 October 2017

Mucosal adjuvanticity and immunogenicity of LTR72, a novel mutant of Escherichia coli heat-labile enterotoxin with partial knockout of ADP-ribosyltransferase activity (English)

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Mucosal Adjuvanticity and Immunogenicity of LTR72, a Novel Mutant of Escherichia coli Heat-labile Enterotoxin with Partial Knockout of ADP-ribosyltransferase Activity (English)

1 reference

10.1084/JEM.187.7.1123

https://api.crossref.org/works/10.1084/JEM.187.7.1123

15 December 2024

Escherichia coli

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Mariagrazia Pizza

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M. Pizza

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15 December 2024

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M. M. Giuliani

1

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G. Del Giudice

2

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V. Giannelli

3

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G. Dougan

4

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G. Douce

5

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R. Rappuoli

6

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publication date

1 April 1998

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13 October 2017

6 April 1998

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15 December 2024

full work available at URL

https://rupress.org/jem/article-pdf/187/7/1123/1688861/98-0026.pdf

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https://europepmc.org/articles/PMC2212201

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Europe PubMed Central

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15 December 2024

https://europepmc.org/articles/PMC2212201?pdf=render

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15 December 2024

Journal of Experimental Medicine

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13 October 2017

187

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13 October 2017

7

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13 October 2017

1123-1132

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Europe PubMed Central

PMC publication ID

13 October 2017

Therapeutic intragastric vaccination against Helicobacter pylori in mice eradicates an otherwise chronic infection and confers protection against reinfection

1 reference

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Intranasal immunogenicity and adjuvanticity of site-directed mutant derivatives of cholera toxin

1 reference

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5 June 2018

Intranasal vaccination of humans with recombinant cholera toxin B subunit induces systemic and local antibody responses in the upper respiratory tract and the vagina.

1 reference

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5 June 2018

A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity

1 reference

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The adjuvant effect of a non-toxic mutant of heat-labile enterotoxin of Escherichia coli for the induction of measles virus-specific CTL responses after intranasal co-immunization with a synthetic peptide

1 reference

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Protease susceptibility and toxicity of heat-labile enterotoxins with a mutation in the active site or in the protease-sensitive loop

1 reference

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5 June 2018

Mutations in the A subunit affect yield, stability, and protease sensitivity of nontoxic derivatives of heat-labile enterotoxin

1 reference

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5 June 2018

Mutants of the Escherichia coli heat-labile enterotoxin with reduced ADP-ribosylation activity or no activity retain the immunogenic properties of the native holotoxin.

1 reference

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5 June 2018

Intranasal immunization with SAG1 protein of Toxoplasma gondii in association with cholera toxin dramatically reduces development of cerebral cysts after oral infection

1 reference

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5 June 2018

Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heat-labile enterotoxin as a mucosal adjuvant

1 reference

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5 June 2018

Potent immunogenicity of the B subunits of Escherichia coli heat-labile enterotoxin: receptor binding is essential and induces differential modulation of lymphocyte subsets

1 reference

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5 June 2018

Refined structure of Escherichia coli heat-labile enterotoxin, a close relative of cholera toxin

1 reference

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Enhancing effect of cholera toxin on interleukin-6 secretion by IEC-6 intestinal epithelial cells: mode of action and augmenting effect of inflammatory cytokines.

1 reference

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5 June 2018

Optimizing oral vaccines: induction of systemic and mucosal B-cell and antibody responses to tetanus toxoid by use of cholera toxin as an adjuvant

1 reference

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5 June 2018

Synergistic action of cholera toxin B subunit (and Escherichia coli heat-labile toxin B subunit) and a trace amount of cholera whole toxin as an adjuvant for nasal influenza vaccine.

1 reference

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5 June 2018

A genetically detoxified derivative of heat-labile Escherichia coli enterotoxin induces neutralizing antibodies against the A subunit

1 reference

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5 June 2018

Role of trypsin-like cleavage at arginine 192 in the enzymatic and cytotonic activities of Escherichia coli heat-labile enterotoxin

1 reference

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5 June 2018

Mutants of Escherichia coli heat-labile toxin lacking ADP-ribosyltransferase activity act as nontoxic, mucosal adjuvants

1 reference

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5 June 2018

Probing the structure-activity relationship of Escherichia coli LT-A by site-directed mutagenesis.

1 reference

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5 June 2018

Construction of nontoxic derivatives of cholera toxin and characterization of the immunological response against the A subunit.

1 reference

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5 June 2018

Dissociation of Escherichia coli heat-labile enterotoxin adjuvanticity from ADP-ribosyltransferase activity

1 reference

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5 June 2018

Actions of cholera toxin and the prevention and treatment of cholera

1 reference

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5 June 2018

Sequence homologies between A subunits of Escherichia coli and Vibrio cholerae enterotoxins

1 reference

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5 June 2018

Amino acid sequence homology between cholera toxin and Escherichia coli heat-labile toxin

1 reference

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5 June 2018

Oligonucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any fragment of DNA.

1 reference

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5 June 2018

Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development

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5 June 2018

New knowledge on pathogenesis of bacterial enteric infections as applied to vaccine development

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5 June 2018

Properties of homogeneous heat-labile enterotoxin from Escherichia coli

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5 June 2018

Detection of Heat-Labile Escherichia coli Enterotoxin with the Use of Adrenal Cells in Tissue Culture

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5 June 2018

Tissue receptor for cholera exotoxin: postulated structure from studies with GM1 ganglioside and related glycolipids.

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5 June 2018

Heat-labile enterotoxin of Escherichia coli. Characterization of different crystal forms.

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5 June 2018

Studies on the genetic and cellular control of sensitivity to enterotoxins in the sealed adult mouse model

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ADP-ribosylation of guanyl nucleotide-binding regulatory proteins by bacterial toxins

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Adjuvant activity of Escherichia coli heat-labile enterotoxin and effect on the induction of oral tolerance in mice to unrelated protein antigens

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Intestinal electrolyte transport and diarrheal disease (1).

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Binding specificities of heat-labile enterotoxins isolated from porcine and human enterotoxigenic Escherichia coli for different gangliosides.

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Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli.

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An oral B subunit: whole cell vaccine against cholera

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Mucosal immunogenicity of genetically detoxified derivatives of heat labile toxin from Escherichia coli

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1 reference

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Genetically engineered nontoxic vaccine adjuvant that combines B cell targeting with immunomodulation by cholera toxin A1 subunit.

1 reference

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Mechanisms for mucosal immunogenicity and adjuvancy of Escherichia coli labile enterotoxin.

1 reference

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Adjuvant action of cholera toxin and pertussis toxin in the induction of IgA antibody response to orally administered antigen.

1 reference

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Killed Campylobacter elicits immune response and protection when administered with an oral adjuvant.

1 reference

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Development of a mouse model of Helicobacter pylori infection that mimics human disease

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Common features of the NAD-binding and catalytic site of ADP-ribosylating toxins.

1 reference

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Enterotoxicity of Bacteria-free Culture-filtrate of Vibrio cholerae

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ADP-ribosyl transferase activity of cholera toxin polypeptide A1 and the effect of limited trypsinolysis

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https://pubmed.ncbi.nlm.nih.gov/9529328

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42 Toxin ADP-ribosyltransferases that act on adenylate cyclase systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/9529328

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effectiveness of cholera toxin B subunit as an adjuvant for nasal influenza vaccination despite pre-existing immunity to CTB

1 reference

https://pubmed.ncbi.nlm.nih.gov/9529328

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholera toxin-catalyzed [32P]ADP-ribosylation of proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/9529328

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The adjuvant effect of Vibrio cholerae and Escherichia coli heat-labile enterotoxins is linked to their ADP-ribosyltransferase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9529328

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental evaluation of antitoxic protective effect of new cholera vaccines in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9529328

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1084/JEM.187.7.1123

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

ResearchGate publication ID

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