TRIF mediates Toll-like receptor 2-dependent inflammatory responses to Borrelia burgdorferi (Q41844903)

13 October 2017

TRIF mediates Toll-like receptor 2-dependent inflammatory responses to Borrelia burgdorferi (English)

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13 October 2017

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Tanja Petnicki-Ocwieja

1

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13 October 2017

Erin Chung

2

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13 October 2017

David I Acosta

3

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13 October 2017

Laurie T Ramos

4

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13 October 2017

Ok S Shin

5

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13 October 2017

Sanjukta Ghosh

6

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13 October 2017

Lester Kobzik

7

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13 October 2017

Xin Li

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13 October 2017

Linden T Hu

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13 October 2017

language of work or name

English

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publication date

19 November 2012

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13 October 2017

Infection and Immunity

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13 October 2017

81

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13 October 2017

2

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13 October 2017

402-410

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Both TLR2 and TRIF contribute to interferon-β production during Listeria infection

13 October 2017

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Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

6 June 2018

1 reference

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MARCO regulates early inflammatory responses against influenza: a useful macrophage function with adverse outcome

6 June 2018

1 reference

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Nod2 Suppresses Borrelia burgdorferi Mediated Murine Lyme Arthritis and Carditis through the Induction of Tolerance

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-beta

6 June 2018

1 reference

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CD14 signaling reciprocally controls collagen deposition and turnover to regulate the development of lyme arthritis.

6 June 2018

1 reference

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Borrelia species induce inflammasome activation and IL-17 production through a caspase-1-dependent mechanism

6 June 2018

1 reference

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Human Integrin α3β1 Regulates TLR2 Recognition of Lipopeptides from Endosomal Compartments

6 June 2018

1 reference

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Inadequate binding of immune regulator factor H is associated with sensitivity of Borrelia lusitaniae to human complement

6 June 2018

1 reference

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Phagocytosis and phagosome acidification are required for pathogen processing and MyD88-dependent responses to Staphylococcus aureus

6 June 2018

1 reference

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Murine toll-like receptor 2 activation induces type I interferon responses from endolysosomal compartments

6 June 2018

1 reference

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The Lyme disease spirochete Borrelia burgdorferi utilizes multiple ligands, including RNA, for interferon regulatory factor 3-dependent induction of type I interferon-responsive genes

6 June 2018

1 reference

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CD14 signaling restrains chronic inflammation through induction of p38-MAPK/SOCS-dependent tolerance

6 June 2018

1 reference

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Nod2 is required for the regulation of commensal microbiota in the intestine

6 June 2018

1 reference

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Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

6 June 2018

1 reference

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Endotoxin tolerance: new mechanisms, molecules and clinical significance

6 June 2018

1 reference

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Toll-like receptors 1 and 2 heterodimers alter Borrelia burgdorferi gene expression in mice and ticks

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

Downstream signals for MyD88-mediated phagocytosis of Borrelia burgdorferi can be initiated by TRIF and are dependent on PI3K.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis

6 June 2018

1 reference

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The caspase 1 inflammasome is not required for control of murine Lyme borreliosis

6 June 2018

1 reference

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Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta

6 June 2018

1 reference

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The roles of TLRs, RLRs and NLRs in pathogen recognition

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

A critical role for type I IFN in arthritis development following Borrelia burgdorferi infection of mice

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: implications for vaccines

6 June 2018

1 reference

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Distinct roles for MyD88 and Toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

Phagocytosis of Borrelia burgdorferi, the Lyme disease spirochete, potentiates innate immune activation and induces apoptosis in human monocytes

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

Cooperation between MyD88 and TRIF pathways in TLR synergy via IRF5 activation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

Phagocytosis of Borrelia burgdorferi and Treponema pallidum potentiates innate immune activation and induces gamma interferon production

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

Borrelia burgdorferi lacking BBK32, a fibronectin-binding protein, retains full pathogenicity

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

MyD88 deficiency results in tissue-specific changes in cytokine induction and inflammation in interleukin-18-independent mice infected with Borrelia burgdorferi

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

Myeloid differentiation antigen 88 deficiency impairs pathogen clearance but does not alter inflammation in Borrelia burgdorferi-infected mice

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

Toll-like receptor 2 plays a pivotal role in host defense and inflammatory response to Borrelia burgdorferi

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

IRAK-M is a negative regulator of Toll-like receptor signaling

6 June 2018

1 reference

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Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

Correlation between plasmid content and infectivity in Borrelia burgdorferi

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

Tumor necrosis factor-alpha -mediated protein kinases in regulation of scavenger receptor and foam cell formation on macrophage

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3553797

Inhibition of macrophage scavenger receptor activity by tumor necrosis factor-alpha is transcriptionally and post-transcriptionally regulated

6 June 2018

1 reference

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SR-A/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens.

6 June 2018

1 reference

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Recognition of Borrelia burgdorferi, the Lyme disease spirochete, by TLR7 and TLR9 induces a type I IFN response by human immune cells

18 August 2018

1 reference

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Borrelia burgdorferi Induces TLR1 and TLR2 in human microglia and peripheral blood monocytes but differentially regulates HLA-class II expression.

18 August 2018

1 reference

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Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products.

18 August 2018

1 reference

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Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi

18 August 2018

1 reference

12 December 2020

MyD88 plays a unique role in host defense but not arthritis development in Lyme disease

1 reference

12 December 2020

Unresponsiveness of MyD88-deficient mice to endotoxin

1 reference

12 December 2020

Functional consequences of CD36 downregulation by TLR signals

1 reference

12 December 2020

Identification of a TLR-independent pathway for Borrelia burgdorferi-induced expression of matrix metalloproteinases and inflammatory mediators through binding to integrin alpha 3 beta 1

1 reference

12 December 2020

T cell infiltration is associated with increased Lyme arthritis in TLR2-/- mice

1 reference

12 December 2020

Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway

1 reference

12 December 2020

Identifiers

DOI

10.1128/IAI.00890-12

1 reference

13 October 2017

1 reference

13 October 2017

PubMed publication ID

23166161

1 reference