Gene therapy in the second eye of RPE65-deficient dogs improves retinal function (Q41835416)

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9 February 2020

title

Gene therapy in the second eye of RPE65-deficient dogs improves retinal function (English)

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9 February 2020

0 references

6

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9 February 2020

Simon M Petersen-Jones

8

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9 February 2020

author name string

M J Annear

1

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9 February 2020

J T Bartoe

2

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S E Barker

3

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9 February 2020

A J Smith

4

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P G Curran

5

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9 February 2020

R R Ali

7

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publication date

12 August 2010

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9 February 2020

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volume

18

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issue

1

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9 February 2020

page(s)

53-61

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AAV retinal transduction in a large animal model species: comparison of a self-complementary AAV2/5 with a single-stranded AAV2/5 vector.

9 February 2020

cites work

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Topographical characterization of cone photoreceptors and the area centralis of the canine retina

6 June 2018

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Characterization of a canine model of autosomal recessive retinitis pigmentosa due to a PDE6A mutation

6 June 2018

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Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial

6 June 2018

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A novel method for objective vision testing in canine models of inherited retinal disease.

6 June 2018

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Effect of gene therapy on visual function in Leber's congenital amaurosis

6 June 2018

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Safety and efficacy of gene transfer for Leber's congenital amaurosis

6 June 2018

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Reversal of blindness in animal models of leber congenital amaurosis using optimized AAV2-mediated gene transfer

6 June 2018

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Immune responses to AAV in clinical trials

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Leber congenital amaurosis - a model for efficient genetic testing of heterogeneous disorders: LXIV Edward Jackson Memorial Lecture

6 June 2018

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Adeno-associated virus serotype 9 vectors transduce murine alveolar and nasal epithelia and can be readministered.

6 June 2018

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Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness

6 June 2018

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6 June 2018

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In vivo gene therapy in young and adult RPE65-/- dogs produces long-term visual improvement.

6 June 2018

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Repeat transduction in the mouse lung by using adeno-associated virus vectors with different serotypes

6 June 2018

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Retinal dystrophy of Swedish briard/briard-beagle dogs is due to a 4-bp deletion in RPE65.

6 June 2018

1 reference

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High-titer adeno-associated viral vectors from a Rep/Cap cell line and hybrid shuttle virus

6 June 2018

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Successful readministration of adeno-associated virus vectors to the mouse lung requires transient immunosuppression during the initial exposure

6 June 2018

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Congenital stationary night blindness in the dog: common mutation in the RPE65 gene indicates founder effect.

6 June 2018

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Mutations in RPE65 cause autosomal recessive childhood–onset severe retinal dystrophy

6 June 2018

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Mutations in RPE65 cause Leber's congenital amaurosis

6 June 2018

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Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence, and readministration.

6 June 2018

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Comparison of tepoxalin, carprofen, and meloxicam for reducing intraocular inflammation in dogs.

6 June 2018

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Gene therapy following subretinal AAV5 vector delivery is not affected by a previous intravitreal AAV5 vector administration in the partner eye.

18 August 2018

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Immunity to adeno-associated virus-mediated gene transfer in a random-bred canine model of Duchenne muscular dystrophy

18 August 2018

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Restoration of vision in RPE65-deficient Briard dogs using an AAV serotype 4 vector that specifically targets the retinal pigmented epithelium

18 August 2018

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18 August 2018

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18 August 2018

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Assessment of structure and function over a 3-year period after gene transfer in RPE65-/- dogs

18 August 2018

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Functional and structural evaluation after AAV.RPE65 gene transfer in the canine model of Leber's congenital amaurosis

18 August 2018

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Repeated adeno-associated virus serotype 2 aerosol-mediated cystic fibrosis transmembrane regulator gene transfer to the lungs of patients with cystic fibrosis: a multicenter, double-blind, placebo-controlled trial

18 August 2018

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Functional and structural recovery of the retina after gene therapy in the RPE65 null mutation dog.

18 August 2018

1 reference

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A deviant immune response to viral proteins and transgene product is generated on subretinal administration of adenovirus and adeno-associated virus

18 August 2018

1 reference

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Gene therapy restores vision in a canine model of childhood blindness

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381842

Additional transduction events after subretinal readministration of recombinant adeno-associated virus

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381842

18 August 2018

Identifiers

DOI

10.1038/GT.2010.111

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Dimensions Publication ID

9 February 2020

0 references

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9 February 2020

PubMed publication ID

20703309

1 reference