Activation of p53 signaling by MI-63 induces apoptosis in acute myeloid leukemia cells (Q41779296)

9 October 2017

Activation of p53 signaling by MI-63 induces apoptosis in acute myeloid leukemia cells (English)

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9 October 2017

acute myeloid leukemia

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6

Hagop Kantarjian

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9 October 2017

9

Gautam Borthakur

1 reference

9 October 2017

8

Vivian Ruvolo

1 reference

9 October 2017

Ismael J Samudio

1

1 reference

9 October 2017

Seshagiri Duvvuri

2

1 reference

9 October 2017

Karen Clise-Dwyer

3

1 reference

9 October 2017

Julie C Watt

4

1 reference

9 October 2017

Duncan Mak

5

1 reference

9 October 2017

Dajun Yang

7

1 reference

9 October 2017

1 May 2010

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9 October 2017

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9 October 2017

51

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9 October 2017

5

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9 October 2017

911-919

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Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation

9 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122268

Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122268

Elevated MDM2 boosts the apoptotic activity of p53-MDM2 binding inhibitors by facilitating MDMX degradation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122268

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122268

Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122268

Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122268

Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122268

MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122268

A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122268

6 June 2018

Surfing the p53 network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122268

Analysis of the degradation function of Mdm2.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122268

The MDM2 gene amplification database

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122268

Regulation of p53 stability by Mdm2

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122268

p53, the cellular gatekeeper for growth and division

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122268

The p53-mdm-2 autoregulatory feedback loop

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122268

Multiple patterns of MDM-2 deregulation in human leukemias: implications in leukemogenesis and prognosis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122268

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122268

Amplification of a gene encoding a p53-associated protein in human sarcomas

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122268

Microsatellite instability and p53 mutations are characteristic of subgroups of acute myeloid leukemia but independent events.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122268

A flow cytometry assay simultaneously detects independent apoptotic parameters

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122268

The prognostic significance of p16(INK4a)/p14(ARF) locus deletion and MDM-2 protein expression in adult acute myelogenous leukemia

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122268

INK4a/ARF locus alterations in human non-Hodgkin's lymphomas mainly occur in tumors with wild-type p53 gene

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122268

Levels of HdmX Expression Dictate the Sensitivity of Normal and Transformed Cells to Nutlin-3

18 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.3109/10428191003731325

The human MDM-2 oncogene is overexpressed in leukemias

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20423286

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Regulation of p53 nuclear export through sequential changes in conformation and ubiquitination

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20423286

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Comprehensive biomarker and genomic analysis identifies p53 status as the major determinant of response to MDM2 inhibitors in chronic lymphocytic leukemia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20423286

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3109/10428191003731325

1 reference

9 October 2017

1 reference

9 October 2017

PubMed publication ID

20423286

1 reference