In vitro and in vivo pharmacology of a structurally novel Na -H exchange inhibitor, T-162559. (Q41779291)

9 October 2017

In vitro and in vivo pharmacology of a structurally novel Na -H exchange inhibitor, T-162559. (English)

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9 October 2017

4

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author name string

Keiji Kusumoto

1

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9 October 2017

Hideki Igata

2

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9 October 2017

Akemi Abe

3

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9 October 2017

Shota Ikeda

4

1 reference

9 October 2017

Ayako Tsuboi

5

1 reference

9 October 2017

Eikoh Imamiya

6

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9 October 2017

Shoji Fukumoto

7

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9 October 2017

Mitsuru Shiraishi

8

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9 October 2017

Toshifumi Watanabe

9

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9 October 2017

language of work or name

English

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publication date

1 April 2002

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British Journal of Pharmacology

9 October 2017

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9 October 2017

135

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9 October 2017

8

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9 October 2017

1995-2003

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Protection of the ischaemic myocardium by Na /H exchange inhibitors: potential mechanisms of action

9 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

The myocardial Na( )-H( ) exchange: structure, regulation, and its role in heart disease

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

Characterization of intracellular pH regulation in the guinea-pig ventricular myocyte.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

A new sodium/hydrogen exchange inhibitor, EMD 85131, limits infarct size in dogs when administered before or after coronary artery occlusion

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

Synthesis of the highly selective Na /H exchange inhibitors cariporide mesilate and (3-methanesulfonyl-4-piperidino-benzoyl) guanidine methanesulfonate

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

Infarct size limitation by a new Na( )-H exchange inhibitor, Hoe 642: difference from preconditioning in the role of protein kinase C.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

Molecular physiology of vertebrate Na /H exchangers

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

The role of Na /H exchange in ischemia-reperfusion

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

Stimulation of mitogen-activated protein kinase and Na /H exchanger in human platelets. Differential effect of phorbol ester and vasopressin

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

Cytosolic pH sensitivity of an expressed human NHE-1 Na( )-H exchanger

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

Pharmacological characterization of stably transfected Na /H antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

Mammalian exchangers and co-transporters

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

Hormonal regulation, pharmacology, and membrane sorting of vertebrate Na /H exchanger isoforms

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

The contribution of ionic imbalance to ischemia/reperfusion-induced injury.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

Molecular cloning and physical and genetic mapping of a novel human Na /H exchanger (NHE5/SLC9A5) to chromosome 16q22.1

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

Amiloride: a molecular probe of sodium transport in tissues and cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

Amiloride and its analogs as tools in the study of ion transport

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

Activation of ion transport pathways by changes in cell volume

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

Potent and selective inhibition of the human Na /H exchanger isoform NHE1 by a novel aminoguanidine derivative T-162559.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

Pharmacological profile of SL 59.1227, a novel inhibitor of the sodium/hydrogen exchanger

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

Preischemic and postischemic treatment with a new Na /H -exchange inhibitor, FR183998, shows cardioprotective effects in rats with cardiac ischemia and reperfusion

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

Effects of MS-31-038, a novel Na( )-H exchange inhibitor, on the myocardial infarct size in rats after postischemic administration

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

Equal reduction in infarct size by ethylisopropyl-amiloride pretreatment and ischemic preconditioning in the in situ rabbit heart

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

Regulation of [Na ]i and [Ca2 ]i in guinea pig myocytes: dual loading of fluorescent indicators SBFI and fluo 3.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

Na /H and Na /Ca2 exchange in regulation of [Na ]i and [Ca2 ]i during metabolic inhibition

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

New Na( )-H exchange inhibitor HOE 694 improves postischemic function and high-energy phosphate resynthesis and reduces Ca2 overload in isolated perfused rabbit heart

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

Interaction of guanidinium and guanidinium derivatives with the Na /H exchange system

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573312

Na( )/H( ) exchange inhibition with HOE642 improves postischemic recovery due to attenuation of Ca(2 ) overload and prolonged acidosis on reperfusion

2 December 2018

1 reference

12 December 2020

Inhibition of the Na( )/H( ) exchanger confers greater cardioprotection against 90 minutes of myocardial ischemia than ischemic preconditioning in dogs

1 reference

12 December 2020

Cardioprotective effect of TY-12533, a novel Na( )/H( ) exchange inhibitor, on ischemia/reperfusion injury

1 reference

12 December 2020

Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Main results of the GUARDIAN trial. Guard during ischemia against necrosis (GUARDIAN) Investigators

1 reference

12 December 2020

Blockade of the Na /H antiport abolishes growth factor-induced DNA synthesis in fibroblasts. Structure-activity relationships in the amiloride series

1 reference

12 December 2020

Volume-regulating behavior of human platelets

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12 December 2020

Characterization of Na /H exchange in platelets

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12 December 2020

Amiloride enhances postischemic ventricular recovery: possible role of Na -H exchange

1 reference

12 December 2020

Role of intracellular Na in Ca2 overload and depressed recovery of ventricular function of reperfused ischemic rat hearts. Possible involvement of H -Na and Na -Ca2 exchange

1 reference

12 December 2020

Rapid determination of the elevated Na( )-H exchange in platelets of patients with essential hypertension using an optical swelling assay

1 reference

12 December 2020

Molecular basis of depression of Ca2 sensitivity of tension by acid pH in cardiac muscles of the mouse and the rat

1 reference

12 December 2020

Na /H Exchanger Activity Does Not Contribute to Protection by Ischemic Preconditioning in the Isolated Rat Heart

1 reference

12 December 2020

Antiarrhythmic effects of cariporide, a novel Na –H exchange inhibitor, on reperfusion ventricular arrhythmias in rat hearts

1 reference

12 December 2020

A Na -H exchange inhibitor (SM-20550) protects from microvascular deterioration and myocardial injury after reperfusion

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.BJP.0704647

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9 October 2017

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9 October 2017

PubMed publication ID

11959803

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