Absence of the complement regulatory molecule CD59a leads to exacerbated neuropathology after traumatic brain injury in mice. (Q41771843)

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19 January 2020

title

Absence of the complement regulatory molecule CD59a leads to exacerbated neuropathology after traumatic brain injury in mice (English)

1 reference

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19 January 2020

main subject

traumatic brain injury

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author

Bryan Paul Morgan

3

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19 January 2020

author name string

Philip F Stahel

1

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19 January 2020

Michael A Flierl

2

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19 January 2020

Ivonne Persigehl

4

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19 January 2020

Christiane Stoll

5

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19 January 2020

Claudia Conrad

6

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19 January 2020

Basel M Touban

7

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19 January 2020

Wade R Smith

8

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19 January 2020

Kathryn Beauchamp

9

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19 January 2020

Oliver I Schmidt

10

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19 January 2020

Wolfgang Ertel

11

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19 January 2020

Iris Leinhase

12

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19 January 2020

publication date

8 January 2009

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Journal of Neuroinflammation

19 January 2020

published in

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19 January 2020

volume

6

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19 January 2020

page(s)

2

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The role of the complement system in CNS inflammatory diseases

19 January 2020

cites work

1 reference

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Serum biomarker concentrations and outcome after pediatric traumatic brain injury

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The mouse complement regulator CD59b is significantly expressed only in testis and plays roles in sperm acrosome activation and motility.

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Spontaneous classical pathway activation and deficiency of membrane regulators render human neurons susceptible to complement lysis

6 June 2018

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Complement C5a anaphylatoxin fragment causes apoptosis in TGW neuroblastoma cells

6 June 2018

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6 June 2018

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An experimental model of closed head injury in mice: pathophysiology, histopathology, and cognitive deficits

6 June 2018

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Complement activation in the central nervous system following blood-brain barrier damage in man.

6 June 2018

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6 June 2018

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Dynamic changes in the recovery after traumatic brain injury in mice: effect of injury severity on T2-weighted MRI abnormalities, and motor and cognitive functions

6 June 2018

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Mannose binding lectin gene deficiency increases susceptibility to traumatic brain injury in mice

18 August 2018

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Reduced tissue damage and improved recovery of motor function after traumatic brain injury in mice deficient in complement component C4.

18 August 2018

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Pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury

18 August 2018

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18 August 2018

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CD59a is the primary regulator of membrane attack complex assembly in the mouse.

18 August 2018

1 reference

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Effects of membrane attack complex of complement on apoptosis in experimental autoimmune encephalomyelitis

18 August 2018

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Intracerebroventricular injection of the terminal complement complex causes inflammatory reaction in the rat brain

18 August 2018

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18 August 2018

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Intrathecal levels of complement-derived soluble membrane attack complex (sC5b-9) correlate with blood-brain barrier dysfunction in patients with traumatic brain injury.

18 August 2018

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18 August 2018

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Activation of the complement cascade and increase of clusterin in the brain following a cortical contusion in the adult rat.

18 August 2018

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18 August 2018

1 reference

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Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal injury in murine acute experimental allergic encephalomyelitis

18 August 2018

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12 December 2020

Targeted deletion of the CD59 gene causes spontaneous intravascular hemolysis and hemoglobinuria

1 reference

12 December 2020

Complement activation in the human brain after traumatic head injury

1 reference

12 December 2020

The Membrane Attack Complex of Complement Causes Severe Demyelination Associated with Acute Axonal Injury

1 reference

12 December 2020

Differential expression of individual complement regulators in the brain and choroid plexus

1 reference

12 December 2020

The role of the complement system in traumatic brain injury

1 reference

12 December 2020

Effect of Soluble Complement Receptor-1 on Neutrophil Accumulation after Traumatic Brain Injury in Rats

1 reference

12 December 2020

Experimental closed head injury: analysis of neurological outcome, blood-brain barrier dysfunction, intracranial neutrophil infiltration, and neuronal cell death in mice deficient in genes for pro-inflammatory cytokines

1 reference

12 December 2020

Identifiers

DOI

10.1186/1742-2094-6-2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19133139 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

19 January 2020

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1742-2094-6-2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19133139 AND SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

19133139

1 reference