The proto-oncogene c-Cbl is a positive regulator of Met-induced MAP kinase activation: a role for the adaptor protein Crk. (Q41758116)

8 October 2017

title

The proto-oncogene c-Cbl is a positive regulator of Met-induced MAP kinase activation: a role for the adaptor protein Crk. (English)

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8 October 2017

M Garcia-Guzman

1

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8 October 2017

E Larsen

series ordinal

2

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8 October 2017

K Vuori

series ordinal

3

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8 October 2017

language of work or name

English

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publication date

1 August 2000

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8 October 2017

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8 October 2017

volume

19

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8 October 2017

issue

35

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8 October 2017

page(s)

4058-4065

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Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential.

8 October 2017

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The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway

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Tyrosine phosphorylation of C-Cbl facilitates adhesion and spreading while suppressing anchorage-independent growth of V-Abl-transformed NIH3T3 fibroblasts

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Efficient Cellular Transformation by the Met Oncoprotein Requires a Functional Grb2 Binding Site and Correlates with Phosphorylation of the Grb2-associated Proteins, Cbl and Gab1

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The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase

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Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation

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Involvement of Shc and Cbl-PI 3-kinase in Lyn-dependent proliferative signaling pathways for G-CSF.

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A Grb2-associated docking protein in EGF- and insulin-receptor signalling

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Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

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Signaling requirements for oncogenic forms of the Met tyrosine kinase receptor.

21 January 2018

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Activating mutations for the Met tyrosine kinase receptor in human cancer

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Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway

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The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

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cbl-3: a new mammalian cbl family protein

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CAS/Crk Coupling Serves as a “Molecular Switch” for Induction of Cell Migration

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The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation

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Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

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Molecules in focus: The c-Cbl oncoprotein

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CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells

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Emerging components of the Crk oncogene product: the first identified adaptor protein

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Two species of human CRK cDNA encode proteins with distinct biological activities

21 January 2018

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Interactions of Cbl with Grb2 and phosphatidylinositol 3'-kinase in activated Jurkat cells

21 January 2018

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A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration

21 January 2018

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The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha

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Association of the Multisubstrate Docking Protein Gab1 with the Hepatocyte Growth Factor Receptor Requires a Functional Grb2 Binding Site Involving Tyrosine 1356

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The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cells

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Mechanism of met oncogene activation

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A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

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Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility

21 January 2018

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Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase

21 January 2018

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Activation of the JNK pathway is essential for transformation by the Met oncogene

21 January 2018

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Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL

21 January 2018

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Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

21 January 2018

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SH2 domains recognize specific phosphopeptide sequences

21 January 2018

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Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase

21 January 2018

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Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins

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c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.

21 January 2018

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Both the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cells

21 January 2018

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Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-Cbl

21 January 2018

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Antisense repression of proto-oncogene c-Cbl enhances activation of the JAK-STAT pathway but not the ras pathway in epidermal growth factor receptor signaling

21 January 2018

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Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases

21 January 2018

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Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

21 January 2018

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Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells.

21 January 2018

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Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7

21 January 2018

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Regulation of beta 1-integrin-mediated cell adhesion by the Cbl adaptor protein

21 January 2018

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Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G

21 January 2018

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Duplication and overexpression of the mutant allele of the MET proto-oncogene in multiple hereditary papillary renal cell tumours

21 January 2018

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7 January 2021

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203750

7 January 2021

The Cbl protooncogene product: from an enigmatic oncogene to center stage of signal transduction.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203750

7 January 2021

The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203750

7 January 2021

Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1203750

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203750

1 reference

Dimensions Publication ID

8 October 2017

1004860569

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1 reference