The phosphatase calcineurin regulates pathological TDP-43 phosphorylation. (Q41628256)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27473149 AND SRC:MED&resulttype=core&format=json

20 March 2020

title

The phosphatase calcineurin regulates pathological TDP-43 phosphorylation (English)

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20 March 2020

0 references

1 reference

1

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20 March 2020

Christopher Keene

11

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20 March 2020

8

Adrian L Oblak

1 reference

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20 March 2020

9

Bernardino Ghetti

1 reference

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20 March 2020

10

Thomas J Montine

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12

Murray A Raskind

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20 March 2020

author name string

Aleen D Saxton

2

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20 March 2020

Pamela J McMillan

3

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20 March 2020

Timothy J Strovas

4

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20 March 2020

Heather N Currey

5

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20 March 2020

Laura M Taylor

6

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20 March 2020

Jeanna M Wheeler

7

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20 March 2020

Thomas D Bird

13

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20 March 2020

Brian C Kraemer

14

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20 March 2020

language of work or name

English

0 references

publication date

29 July 2016

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20 March 2020

published in

Acta Neuropathologica

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20 March 2020

volume

132

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20 March 2020

issue

4

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20 March 2020

page(s)

545-561

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TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways

20 March 2020

cites work

1 reference

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TDP-35 sequesters TDP-43 into cytoplasmic inclusions through binding with RNA

6 October 2017

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Frontotemporal dementia: a bridge between dementia and neuromuscular disease

6 October 2017

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An acetylation switch controls TDP-43 function and aggregation propensity

6 October 2017

1 reference

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The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43

6 October 2017

1 reference

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Calcineurin upregulates local Ca(2 ) signaling through ryanodine receptor-1 in airway smooth muscle cells

6 October 2017

1 reference

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TDP-43 is a key player in the clinical features associated with Alzheimer's disease

6 October 2017

1 reference

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TDP-43 pathology, cognitive decline, and dementia in old age

6 October 2017

1 reference

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CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration.

6 October 2017

1 reference

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Neural functions of calcineurin in synaptic plasticity and memory

6 October 2017

1 reference

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Alteration of POLDIP3 splicing associated with loss of function of TDP-43 in tissues affected with ALS

6 October 2017

1 reference

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National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

6 October 2017

1 reference

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TDP-43 regulates global translational yield by splicing of exon junction complex component SKAR.

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach

6 October 2017

1 reference

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A harmonized classification system for FTLD-TDP pathology

6 October 2017

1 reference

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Phosphorylation Promotes Neurotoxicity in aCaenorhabditis elegansModel of TDP-43 Proteinopathy

6 October 2017

1 reference

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Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments

6 October 2017

1 reference

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TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy.

6 October 2017

1 reference

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Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Tacrolimus-associated posterior reversible encephalopathy syndrome after solid organ transplantation.

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Multiplex SILAC analysis of a cellular TDP-43 proteinopathy model reveals protein inclusions associated with SUMOylation and diverse polyubiquitin chains

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Structural determinants of the cellular localization and shuttling of TDP-43.

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Two German kindreds with familial amyotrophic lateral sclerosis due to TARDBP mutations

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Age, model for end-stage liver disease score, and organ functioning predict posttransplant tacrolimus neurotoxicity

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Abnormal TDP-43 immunoreactivity in AD modifies clinicopathologic and radiologic phenotype.

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

An up-date review on individualized dosage adjustment of calcineurin inhibitors in organ transplant patients

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Calcium signalling in growth cone migration

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Calcineurin, a calcium/calmodulin-dependent protein phosphatase, is involved in movement, fertility, egg laying, and growth in Caenorhabditis elegans

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Calcineurin as a multifunctional regulator

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Potential role of calcineurin for brain ischemia and traumatic injury

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Identification and characterization of the vesicular GABA transporter

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Molecular cloning and chromosomal mapping of the human gene for the testis-specific catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A)

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Calcineurin: a calcium- and calmodulin-binding protein of the nervous system

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1.

6 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Expression of the calmodulin-dependent protein phosphatase, calcineurin, in rat brain: developmental patterns and the role of nigrostriatal innervation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

4-Hydroxynonenal induces persistent insolubilization of TDP-43 and alters its intracellular localization.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

TDP-43 pathology is present in most post-encephalitic parkinsonism brains

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Colocalization of transactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington disease

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Activity of protein phosphatase calcineurin is decreased in sporadic and familial amyotrophic lateral sclerosispatients

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Negative regulation and gain control of sensory neurons by the C. elegans calcineurin TAX-6.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Regulation of calcineurin by metal ions. Mechanism of activation by Ni2 and an enhanced response to Ca2 /calmodulin

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5026939

Activation of calcineurin by nickel ions

19 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27473149

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Accumulation of phosphorylated TDP-43 in brains of patients with argyrophilic grain disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27473149

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Aggregation of the 35‐kDa fragment of TDP‐43 causes formation of cytoplasmic inclusions and alteration of RNA processing

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27473149

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S00401-016-1600-Y

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27473149 AND SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27473149 AND SRC:MED&resulttype=core&format=json

20 March 2020

PubMed publication ID

27473149

1 reference