The pathway to GTPase activation of elongation factor SelB on the ribosome (Q41600073)

4 October 2017

title

The pathway to GTPase activation of elongation factor SelB on the ribosome (English)

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4 October 2017

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4 October 2017

11

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4 October 2017

Lars V Bock

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Cristina Maracci

object named as

Cristina Maracci

4

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Alena Paleskava

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Alena Paleskava

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Gunnar F. Schröder

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Gunnar F Schröder

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author name string

Piotr Neumann

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4 October 2017

Zhe Wang

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4 October 2017

Andrey L Konevega

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4 October 2017

Helmut Grubmüller

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4 October 2017

Ralf Ficner

10

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4 October 2017

Holger Stark

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4 October 2017

language of work or name

English

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publication date

14 November 2016

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4 October 2017

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4 October 2017

volume

540

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4 October 2017

issue

7631

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4 October 2017

page(s)

80-85

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Biosynthesis of selenoproteins--an overview

4 October 2017

cites work

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Protein factors mediating selenoprotein synthesis

21 January 2018

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Crystal structure of active elongation factor Tu reveals major domain rearrangements

21 January 2018

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Thermodynamic and kinetic framework of selenocysteyl-tRNASec recognition by elongation factor SelB

21 January 2018

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Tertiary structure of bacterial selenocysteine tRNA

21 January 2018

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Features of the formate dehydrogenase mRNA necessary for decoding of the UGA codon as selenocysteine

21 January 2018

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Crystal structure of the full-length bacterial selenocysteine-specific elongation factor SelB.

21 January 2018

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Selenocysteine tRNA-specific elongation factor SelB is a structural chimaera of elongation and initiation factors

21 January 2018

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Domain structure of the prokaryotic selenocysteine-specific elongation factor SelB.

21 January 2018

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The crystal structure of Cys-tRNACys-EF-Tu-GDPNP reveals general and specific features in the ternary complex and in tRNA

21 January 2018

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Selenocysteine incorporation machinery and the role of selenoproteins in development and health

21 January 2018

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Natural and synthetic selenoproteins

21 January 2018

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Update on selenoprotein biosynthesis

21 January 2018

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Recognition of the mRNA selenocysteine insertion sequence by the specialized translational elongation factor SELB.

21 January 2018

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Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites

21 January 2018

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Interaction of a selenocysteine-incorporating tRNA with elongation factor Tu from E.coli

21 January 2018

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The interface between Escherichia coli elongation factor Tu and aminoacyl-tRNA.

21 January 2018

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Understanding the sequence specificity of tRNA binding to elongation factor Tu using tRNA mutagenesis.

21 January 2018

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The tRNA specificity of Thermus thermophilus EF-Tu

21 January 2018

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Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation

21 January 2018

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Review: Translational GTPases

21 January 2018

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Induced fit in initial selection and proofreading of aminoacyl-tRNA on the ribosome

21 January 2018

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Partitioning between recoding and termination at a stop codon-selenocysteine insertion sequence

21 January 2018

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Evolutionary optimization of speed and accuracy of decoding on the ribosome

21 January 2018

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Translation at the single-molecule level

21 January 2018

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Selection of tRNA by the ribosome requires a transition from an open to a closed form

21 January 2018

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Recognition of cognate transfer RNA by the 30S ribosomal subunit

21 January 2018

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Structures of the bacterial ribosome in classical and hybrid states of tRNA binding

21 January 2018

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Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy

21 January 2018

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The Mechanism for Activation of GTP Hydrolysis on the Ribosome

21 January 2018

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Intact aminoacyl-tRNA is required to trigger GTP hydrolysis by elongation factor Tu on the ribosome

21 January 2018

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An active role for tRNA in decoding beyond codon:anticodon pairing

21 January 2018

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How mutations in tRNA distant from the anticodon affect the fidelity of decoding

21 January 2018

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Interaction of elongation factors EF-G and EF-Tu with a conserved loop in 23S RNA.

21 January 2018

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Essential role of histidine 84 in elongation factor Tu for the chemical step of GTP hydrolysis on the ribosome

21 January 2018

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Ribosome-induced tuning of GTP hydrolysis by a translational GTPase

21 January 2018

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Converting structural information into an allosteric-energy-based picture for elongation factor Tu activation by the ribosome

21 January 2018

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Energetics of activation of GTP hydrolysis on the ribosome

21 January 2018

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Elongation factor G bound to the ribosome in an intermediate state of translocation

21 January 2018

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Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome.

21 January 2018

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Transient kinetics, fluorescence, and FRET in studies of initiation of translation in bacteria

21 January 2018

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GTP consumption of elongation factor Tu during translation of heteropolymeric mRNAs

21 January 2018

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Purification and characterization of hexahistidine-tagged elongation factor SelB

21 January 2018

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Thermodynamics of the GTP-GDP-operated conformational switch of selenocysteine-specific translation factor SelB.

21 January 2018

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Single-step purification of specific tRNAs by hydrophobic tagging.

21 January 2018

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Towards understanding selenocysteine incorporation into bacterial proteins

21 January 2018

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Purine bases at position 37 of tRNA stabilize codon-anticodon interaction in the ribosomal A site by stacking and Mg2 -dependent interactions

21 January 2018

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Transient conformational states of aminoacyl-tRNA during ribosome binding catalyzed by elongation factor Tu.

21 January 2018

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Kinetic determinants of high-fidelity tRNA discrimination on the ribosome

21 January 2018

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Structure of the E. coli ribosome-EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM

21 January 2018

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Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process

21 January 2018

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RELION: implementation of a Bayesian approach to cryo-EM structure determination

21 January 2018

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High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

21 January 2018

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Quantifying the local resolution of cryo-EM density maps

21 January 2018

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UCSF Chimera--a visualization system for exploratory research and analysis

21 January 2018

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Software for handling macromolecular envelopes

21 January 2018

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Version 1.2 of the Crystallography and NMR system

21 January 2018

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

21 January 2018

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

21 January 2018

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Improved molecular replacement by density- and energy-guided protein structure optimization

21 January 2018

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Refinement of protein structures into low-resolution density maps using rosetta

21 January 2018

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The HHpred interactive server for protein homology detection and structure prediction

21 January 2018

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Crystal structure of an mRNA-binding fragment of Moorella thermoacetica elongation factor SelB.

21 January 2018

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Structural insight into a molecular switch in tandem winged-helix motifs from elongation factor SelB

21 January 2018

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Features and development of Coot

21 January 2018

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Semiautomated model building for RNA crystallography using a directed rotameric approach

21 January 2018

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Correcting pervasive errors in RNA crystallography through enumerative structure prediction

21 January 2018

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Maximum-likelihood density modification

21 January 2018

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Linking Crystallographic Model and Data Quality

21 January 2018

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Overview of the CCP4 suite and current developments

21 January 2018

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Energy barriers and driving forces in tRNA translocation through the ribosome

21 January 2018

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GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

21 January 2018

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The missing term in effective pair potentials

21 January 2018

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Determination of alkali and halide monovalent ion parameters for use in explicitly solvated biomolecular simulations

21 January 2018

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Automatic atom type and bond type perception in molecular mechanical calculations

21 January 2018

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Essential dynamics of proteins

21 January 2018

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Is the sequence-specific binding of aminoacyl-tRNAs by EF-Tu universal among bacteria?

21 January 2018

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Engineering the elongation factor Tu for efficient selenoprotein synthesis.

21 January 2018

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Decameric SelAbullettRNASec Ring Structure Reveals Mechanism of Bacterial Selenocysteine Formation

21 January 2018

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Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM

21 January 2018

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mRNA helicase activity of the ribosome

21 January 2018

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Regulation of the Mammalian Elongation Cycle by Subunit Rolling: A Eukaryotic-Specific Ribosome Rearrangement

21 January 2018

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A ratchet-like inter-subunit reorganization of the ribosome during translocation

21 January 2018

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Improved side-chain torsion potentials for the Amber ff99SB protein force field

21 January 2018

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12 December 2020

Selenoprotein biosynthesis: purification and assay of components involved in selenocysteine biosynthesis and insertion in Escherichia coli

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12 December 2020

The reaction of ribosomes with elongation factor Tu.GTP complexes. Aminoacyl-tRNA-independent reactions in the elongation cycle determine the accuracy of protein synthesis.

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12 December 2020

Antideterminants present in minihelix(Sec) hinder its recognition by prokaryotic elongation factor Tu.

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12 December 2020

Inhibition of selenoprotein synthesis by selenocysteine tRNA[Ser]Sec lacking isopentenyladenosine

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12 December 2020

AMBER Force Field Parameters for the Naturally Occurring Modified Nucleosides in RNA

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12 December 2020

Ribosome interactions of aminoacyl-tRNA and elongation factor Tu in the codon-recognition complex

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12 December 2020

The function of selenocysteine synthase and SELB in the synthesis and incorporation of selenocysteine

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12 December 2020

Dual use of GTP hydrolysis by elongation factor G on the ribosome

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12 December 2020

Is there proofreading during polypeptide synthesis?

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12 December 2020

Coding from a distance: dissection of the mRNA determinants required for the incorporation of selenocysteine into protein

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12 December 2020

Identifiers

DOI

10.1038/NATURE20560

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4 October 2017

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