Monomer-dependent secondary nucleation in amyloid formation (Q41579457)

4 October 2017

Monomer-dependent secondary nucleation in amyloid formation (English)

1 reference

4 October 2017

1

Sara Linse

1 reference

4 October 2017

15 August 2017

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4 October 2017

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Creative Commons Attribution 4.0 International

4 October 2017

start time

1 August 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method

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Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication

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Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade

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Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes

6 June 2018

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Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease

6 June 2018

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Atomic-resolution structure of a disease-relevant Aβ(1-42) amyloid fibril

6 June 2018

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Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils

6 June 2018

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Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein.

6 June 2018

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Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation

6 June 2018

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Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide

6 June 2018

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Molecular mechanisms of protein aggregation from global fitting of kinetic models.

6 June 2018

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Direct High Affinity Interaction between Aβ42 and GSK3α Stimulates Hyperphosphorylation of Tau. A New Molecular Link in Alzheimer's Disease?

6 June 2018

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Amyloid Fibres: Inert End-Stage Aggregates or Key Players in Disease?

6 June 2018

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N-Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42

6 June 2018

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Structure of the toxic core of α-synuclein from invisible crystals

6 June 2018

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Zinc as chaperone-mimicking agent for retardation of amyloid β peptide fibril formation

6 June 2018

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Secondary Crystal Nucleation: Nuclei Breeding Factory Uncovered

6 June 2018

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On the lag phase in amyloid fibril formation

6 June 2018

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A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

6 June 2018

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Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

6 June 2018

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Atomic-resolution three-dimensional structure of amyloid β fibrils bearing the Osaka mutation

6 June 2018

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Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

6 June 2018

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The amyloid state and its association with protein misfolding diseases.

6 June 2018

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Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity

6 June 2018

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Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation

6 June 2018

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Identification and quantification of amyloid beta-related peptides in human plasma using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

6 June 2018

1 reference

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Membrane interaction of α-synuclein in different aggregation states

6 June 2018

1 reference

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Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism

6 June 2018

1 reference

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The amyloid state of proteins in human diseases

6 June 2018

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From macroscopic measurements to microscopic mechanisms of protein aggregation

6 June 2018

1 reference

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Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations

6 June 2018

1 reference

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Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations

6 June 2018

1 reference

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Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments

6 June 2018

1 reference

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Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species

6 June 2018

1 reference

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An analytical solution to the kinetics of breakable filament assembly

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Atomic structure of the cross-β spine of islet amyloid polypeptide (amylin)

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Chiral symmetry breaking in sodium chlorate crystallizaton

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Fiber-dependent amyloid formation as catalysis of an existing reaction pathway

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Protein misfolding, functional amyloid, and human disease

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

The X-ray interpretation of denaturation and the structure of the seed globulins

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Raft lipids as common components of human extracellular amyloid fibrils

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

The structural basis of protein folding and its links with human disease

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Multiple quantum solid-state NMR indicates a parallel, not antiparallel, organization of beta-sheets in Alzheimer's beta-amyloid fibrils

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Synucleins in synaptic plasticity and neurodegenerative disorders

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Principles that govern the folding of protein chains

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Kinetics of sickle hemoglobin polymerization. II. A double nucleation mechanism.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

The molecular pathology of Alzheimer's disease

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Amyloid Precursor Protein (APP) and ΒZA4 Amyloid in the Etiology of Alzheimer's Disease: Precursor-Product Relationships in the Derangement of Neuronal Function

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Alzheimer's disease: the amyloid cascade hypothesis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Ionic Strength Modulation of the Free Energy Landscape of Aβ40 Peptide Fibril Formation.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

A hexameric peptide barrel as building block of amyloid-β protofibrils

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Surface effects on aggregation kinetics of amyloidogenic peptides.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Quantification of the concentration of Aβ42 propagons during the lag phase by an amyloid chain reaction assay.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Single point mutations induce a switch in the molecular mechanism of the aggregation of the Alzheimer's disease associated Aβ42 peptide

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Secondary nucleation and accessible surface in insulin amyloid fibril formation.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Prion replication and secondary nucleation

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5578932

Secondary Nucleation — A Review

19 August 2018

1 reference

https://api.crossref.org/works/10.1007/S12551-017-0289-Z

The Aβ40 and Aβ42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12551-017-0289-Z

Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12551-017-0289-Z

Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12551-017-0289-Z

10.1007/S12551-017-0289-Z

21 January 2018

Identifiers

DOI

1 reference

4 October 2017

1 reference

PMC publication ID

5578932

4 October 2017

PubMed publication ID

28812278

1 reference

PMC publication ID

5578932