The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice That Is Reversed by Tropomyosin Receptor Kinase B Activation. (Q41554744)

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scientific article published on 12 June 2015

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English	The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice That Is Reversed by Tropomyosin Receptor Kinase B Activation.	scientific article published on 12 June 2015

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20 February 2020

The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice That Is Reversed by Tropomyosin Receptor Kinase B Activation (English)

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20 February 2020

Vincent Warnault

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20 February 2020

Linda Wilbrecht

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Linda Wilbrecht

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Khanhky Phamluong

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Stephen M Massa

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Frank M Longo

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Dorit Ron

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Biological Psychiatry

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20 February 2020

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20 February 2020

Corticostriatal BDNF and alcohol addiction

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MicroRNA-30a-5p in the prefrontal cortex controls the transition from moderate to excessive alcohol consumption.

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6 June 2018

Valence-specific effects of BDNF Val66Met polymorphism on dopaminergic stress and reward processing in humans

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6 June 2018

Rodent models for compulsive alcohol intake

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Intermittent ethanol access schedule in rats as a preclinical model of alcohol abuse

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6 June 2018

microRNA-206 in rat medial prefrontal cortex regulates BDNF expression and alcohol drinking

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BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade.

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BDNF-TrkB receptor regulation of distributed adult neural plasticity, memory formation, and psychiatric disorders

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Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction

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6 June 2018

BDNF mechanisms in late LTP formation: A synthesis and breakdown.

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Disrupted ventromedial prefrontal function, alcohol craving, and subsequent relapse risk

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Addiction: failure of control over maladaptive incentive habits

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6 June 2018

Subjective response to alcohol among alcohol-dependent individuals: effects of the μ-opioid receptor (OPRM1) gene and alcoholism severity

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6 June 2018

BDNF-mediated regulation of ethanol consumption requires the activation of the MAP kinase pathway and protein synthesis

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6 June 2018

Current perspectives on the neurobiology of drug addiction: a focus on genetics and factors regulating gene expression

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6 June 2018

Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking

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6 June 2018

Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxic-ischemic stroke

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6 June 2018

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6 June 2018

The BDNF Val66Met polymorphism impairs synaptic transmission and plasticity in the infralimbic medial prefrontal cortex

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6 June 2018

BDNF Val(66)Met genotype is associated with drug-seeking phenotypes in heroin-dependent individuals: a pilot study

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6 June 2018

A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome

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6 June 2018

Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex

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6 June 2018

BDNF function as a potential mediator of bipolar disorder and post-traumatic stress disorder comorbidity.

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6 June 2018

Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder

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6 June 2018

Animal models of obsessive-compulsive disorder: exploring pharmacology and neural substrates

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Motivation for alcohol becomes resistant to quinine adulteration after 3 to 4 months of intermittent alcohol self-administration

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Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

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6 June 2018

A genetic variant BDNF polymorphism alters extinction learning in both mouse and human

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6 June 2018

Endogenous BDNF in the dorsolateral striatum gates alcohol drinking

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6 June 2018

Escalating ethanol intake is associated with altered corticostriatal BDNF expression

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6 June 2018

Variant BDNF Val66Met polymorphism affects extinction of conditioned aversive memory

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6 June 2018

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6 June 2018

Acamprosate and naltrexone treatment effects on ethanol and sucrose seeking and intake in ethanol-dependent and nondependent rats

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6 June 2018

Parallel and interactive learning processes within the basal ganglia: relevance for the understanding of addiction

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6 June 2018

Addiction and the brain antireward system

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6 June 2018

Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking

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6 June 2018

Neural systems of reinforcement for drug addiction: from actions to habits to compulsion

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6 June 2018

ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin.

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6 June 2018

Efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence: a systematic review

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6 June 2018

The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function

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Addiction and the brain: The neurobiology of compulsion and its persistence

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Coexpression of neurotrophins and their receptors in neurons of the central nervous system

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A pharmacogenetic determinant of mu-opioid receptor antagonist effects on alcohol reward and consumption: evidence from humanized mice.

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Alcohol use in adults

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19 August 2018

PTSD risk is associated with BDNF Val66Met and BDNF overexpression.

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Association of alcohol dehydrogenase polymorphisms and life-style factors with excessive alcohol intake within the Spanish population (EPIC-Spain).

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Alterations of brain-derived neurotrophic factor serum levels in patients with alcohol dependence.

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Multiple polymorphisms in genes of the adrenergic stress system confer vulnerability to alcohol abuse

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19 August 2018

Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety.

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19 August 2018

Innate differences in the expression of brain-derived neurotrophic factor in the regions within the extended amygdala between alcohol preferring and nonpreferring rats

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19 August 2018

Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake

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19 August 2018

Decreased plasma brain-derived neurotrophic factor levels in patients with alcohol dependence.

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19 August 2018

Central and medial amygdaloid brain-derived neurotrophic factor signaling plays a critical role in alcohol-drinking and anxiety-like behaviors.

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19 August 2018

The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology.

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19 August 2018

Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons.

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19 August 2018

Ethanol consumption and serotonin-1A (5-HT1A) receptor function in heterozygous BDNF ( /-) mice

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19 August 2018

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12 December 2020

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10.1016/J.BIOPSYCH.2015.06.007

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Europe PubMed Central

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20 February 2020

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20 February 2020

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20 February 2020

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