Phosphorylation of JAK2 at serine 523: a negative regulator of JAK2 that is stimulated by growth hormone and epidermal growth factor. (Q41493279)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16705159 AND SRC:MED&resulttype=core&format=json

21 January 2020

title

Phosphorylation of JAK2 at serine 523: a negative regulator of JAK2 that is stimulated by growth hormone and epidermal growth factor (English)

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21 January 2020

1 reference

4

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21 January 2020

Ole N Jensen

5

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21 January 2020

author name string

Anna M Mazurkiewicz-Munoz

1

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21 January 2020

Lawrence S Argetsinger

2

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21 January 2020

Jean-Louis K Kouadio

3

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21 January 2020

Joel M Cline

6

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21 January 2020

Christin Carter-Su

7

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21 January 2020

language of work or name

English

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publication date

1 June 2006

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Molecular and Cellular Biology

21 January 2020

published in

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21 January 2020

volume

26

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21 January 2020

issue

11

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21 January 2020

page(s)

4052-4062

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Phosphorylation of Jak2 on Ser(523) inhibits Jak2-dependent leptin receptor signaling

21 January 2020

cites work

1 reference

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A gain-of-function mutation of JAK2 in myeloproliferative disorders

11 June 2018

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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

11 June 2018

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A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

11 June 2018

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Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

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11 June 2018

The Janus kinases (Jaks)

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Determination of the transphosphorylation sites of Jak2 kinase.

11 June 2018

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Phosphorylation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-2 reduces receptor signaling and interaction with the Na( )/H( ) exchanger regulatory factor

11 June 2018

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Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes.

11 June 2018

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Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling

11 June 2018

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Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity

11 June 2018

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The use of in vitro peptide-library screens in the analysis of phosphoserine/threonine-binding domain structure and function

11 June 2018

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Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta

11 June 2018

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Growth hormone alters epidermal growth factor receptor binding affinity via activation of extracellular signal-regulated kinases in 3T3-F442A cells

11 June 2018

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Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain

11 June 2018

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Epidermal growth factor receptor: mechanisms of activation and signalling.

11 June 2018

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Growth hormone-induced phosphorylation of epidermal growth factor (EGF) receptor in 3T3-F442A cells. Modulation of EGF-induced trafficking and signaling

11 June 2018

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The Jak/STAT pathway in model organisms: emerging roles in cell movement

11 June 2018

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Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters.

11 June 2018

1 reference

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Jak2 is involved in c-Myc induction by Bcr-Abl

11 June 2018

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Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein

11 June 2018

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The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction

11 June 2018

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Molecular aspects of primary immunodeficiencies: lessons from cytokine and other signaling pathways.

11 June 2018

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Pinning down proline-directed phosphorylation signaling

11 June 2018

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The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor

11 June 2018

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TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B

11 June 2018

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Characterization of phosphoproteins from electrophoretic gels by nanoscale Fe(III) affinity chromatography with off-line mass spectrometry analysis

11 June 2018

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The erythropoietin receptor cytosolic juxtamembrane domain contains an essential, precisely oriented, hydrophobic motif

11 June 2018

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Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

11 June 2018

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Role of ras-dependent ERK activation in phorbol ester-induced endothelial cell barrier dysfunction

11 June 2018

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The role of STAT proteins in growth hormone signaling

11 June 2018

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Regulation of the Jak2 tyrosine kinase by its pseudokinase domain

11 June 2018

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Growth hormone-induced alteration in ErbB-2 phosphorylation status in 3T3-F442A fibroblasts

11 June 2018

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Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

11 June 2018

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Identification of SH2-bbeta as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2.

11 June 2018

1 reference

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The N-termini of FAK and JAKs contain divergent band 4.1 domains

11 June 2018

1 reference

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The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

11 June 2018

1 reference

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Direct effects of phosphorylation on the preferred backbone conformation of peptides: a nuclear magnetic resonance study

11 June 2018

1 reference

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Growth hormone stimulates the formation of a multiprotein signaling complex involving p130(Cas) and CrkII. Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK).

11 June 2018

1 reference

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Growth hormone stimulates phosphorylation and activation of elk-1 and expression of c-fos, egr-1, and junB through activation of extracellular signal-regulated kinases 1 and 2.

11 June 2018

1 reference

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Platelet-derived growth factor (PDGF) stimulates the association of SH2-Bbeta with PDGF receptor and phosphorylation of SH2-Bbeta

11 June 2018

1 reference

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Identification of a novel inhibitor of mitogen-activated protein kinase kinase

11 June 2018

1 reference

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Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity

11 June 2018

1 reference

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A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory

11 June 2018

1 reference

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Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone

11 June 2018

1 reference

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A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

11 June 2018

1 reference

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Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling

11 June 2018

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STAT3 Serine Phosphorylation by ERK-Dependent and -Independent Pathways Negatively Modulates Its Tyrosine Phosphorylation

11 June 2018

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Transcriptional inhibition by Stat5. Differential activities at growth-related versus differentiation-specific promoters

11 June 2018

1 reference

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Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia

11 June 2018

1 reference

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Signaling Molecules Involved in Coupling Growth Hormone Receptor to Mitogen-Activated Protein Kinase Activation*

11 June 2018

1 reference

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Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop

11 June 2018

1 reference

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A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.

11 June 2018

1 reference

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Growth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling

11 June 2018

1 reference

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Mechanism of signaling by growth hormone receptor

11 June 2018

1 reference

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Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

11 June 2018

1 reference

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Using CLUSTAL for multiple sequence alignments

11 June 2018

1 reference

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Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction

11 June 2018

1 reference

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Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

11 June 2018

1 reference

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The conserved box 1 motif of cytokine receptors is required for association with JAK kinases

11 June 2018

1 reference

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The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain

11 June 2018

1 reference

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Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

11 June 2018

1 reference

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Regions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptor

11 June 2018

1 reference

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High-efficiency transformation of mammalian cells by plasmid DNA

11 June 2018

1 reference

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Growth hormone (GH) stimulates protein synthesis in cells transfected with GH receptor complementary DNA.

11 June 2018

1 reference

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Growth hormone stimulates the tyrosine phosphorylation of 42- and 45-kDa ERK-related proteins

11 June 2018

1 reference

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Growth hormone activates mitogen-activated protein kinase and S6 kinase and promotes intracellular tyrosine phosphorylation in 3T3-F442A preadipocytes

11 June 2018

1 reference

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Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells

11 June 2018

1 reference

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Stimulation by growth hormone of MAP kinase activity in 3T3-F442A fibroblasts

11 June 2018

1 reference

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Growth hormone (GH) induction of tyrosine phosphorylation and activation of mitogen-activated protein kinases in cells transfected with rat GH receptor cDNA.

11 June 2018

1 reference

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Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity

17 June 2018

1 reference

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C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity

2 December 2018

1 reference

12 December 2020

Receptors for the phorbol ester tumour promoters

1 reference

12 December 2020

Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity

1 reference

12 December 2020

Janus kinase 2-dependent activation of p38 mitogen-activated protein kinase by growth hormone. Resultant transcriptional activation of ATF-2 and CHOP, cytoskeletal re-organization and mitogenesis

1 reference

12 December 2020

Regulation of Jak2 tyrosine kinase by protein kinase C during macrophage differentiation of IL-3-dependent myeloid progenitor cells

1 reference

12 December 2020

JAK2, a third member of the JAK family of protein tyrosine kinases

1 reference

12 December 2020

Interaction of the growth hormone receptor cytoplasmic domain with the JAK2 tyrosine kinase

1 reference

12 December 2020

Identifiers

DOI

10.1128/MCB.01591-05

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16705159 AND SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16705159 AND SRC:MED&resulttype=core&format=json

21 January 2020

PubMed publication ID

16705159

1 reference