Activation of PDE2 and PDE5 by specific GAF ligands: delayed activation of PDE5. (Q41485148)

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9 February 2020

title

Activation of PDE2 and PDE5 by specific GAF ligands: delayed activation of PDE5 (English)

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9 February 2020

author

Hans-Gottfried Genieser

series ordinal

3

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9 February 2020

4

Doris Koesling

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9 February 2020

5

Michael Russwurm

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9 February 2020

author name string

Ronald Jäger

series ordinal

1

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9 February 2020

Frank Schwede

series ordinal

2

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9 February 2020

language of work or name

English

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publication date

1 December 2010

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British Journal of Pharmacology

9 February 2020

published in

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9 February 2020

volume

161

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9 February 2020

issue

7

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9 February 2020

page(s)

1645-1660

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Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct

9 February 2020

cites work

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Dual acylation of PDE2A splice variant 3: targeting to synaptic membranes

11 June 2018

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Design of fluorescence resonance energy transfer (FRET)-based cGMP indicators: a systematic approach

11 June 2018

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11 June 2018

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cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11

11 June 2018

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In vivo reconstitution of the negative feedback in nitric oxide/cGMP signaling: role of phosphodiesterase type 5 phosphorylation

11 June 2018

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Molecular determinants for cyclic nucleotide binding to the regulatory domains of phosphodiesterase 2A

11 June 2018

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Direct activation of PDE5 by cGMP: long-term effects within NO/cGMP signaling

11 June 2018

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PDE5 is converted to an activated state upon cGMP binding to the GAF A domain

11 June 2018

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The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding

11 June 2018

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Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (Type 5) by sildenafil and related compounds

11 June 2018

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Binding of cGMP to both allosteric sites of cGMP-binding cGMP-specific phosphodiesterase (PDE5) is required for its phosphorylation

11 June 2018

1 reference

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The GAF domain: an evolutionary link between diverse phototransducing proteins.

11 June 2018

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The structure of a bovine lung cGMP-binding, cGMP-specific phosphodiesterase deduced from a cDNA clone.

11 June 2018

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Characterization of a novel cGMP binding protein from rat lung

11 June 2018

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Separate phosphodiesterases for the hydrolysis of cyclic adenosine 3',5'-monophosphate and cyclic guanosine 3',5'-monophosphate in rat liver.

11 June 2018

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

11 June 2018

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Specificity of cGMP binding to a purified cGMP-stimulated phosphodiesterase from bovine adrenal tissue

11 June 2018

1 reference

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Substrate- and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP.

11 June 2018

1 reference

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Structure and function studies of the cGMP-stimulated phosphodiesterase

11 June 2018

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Slow Transitions and Hysteretic Behavior in Enzymes

11 June 2018

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Substrate and effector specificity of a guanosine 3':5'-monophosphate phosphodiesterase from rat liver

11 June 2018

1 reference

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Multiple affinity states of cGMP-specific phosphodiesterase for sildenafil inhibition defined by cGMP-dependent and cGMP-independent mechanisms

11 June 2018

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19 August 2018

A lifetime of kinetics

1 reference

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Cyclic nucleotide analogs as probes of signaling pathways.

19 August 2018

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Kinetics of a cellular nitric oxide/cGMP/phosphodiesterase-5 pathway

19 August 2018

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[3H]sildenafil binding to phosphodiesterase-5 is specific, kinetically heterogeneous, and stimulated by cGMP.

19 August 2018

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Phosphorylation of isolated human phosphodiesterase-5 regulatory domain induces an apparent conformational change and increases cGMP binding affinity

19 August 2018

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Regulation of cGMP-specific phosphodiesterase (PDE5) phosphorylation in smooth muscle cells

19 August 2018

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Rapid nitric oxide-induced desensitization of the cGMP response is caused by increased activity of phosphodiesterase type 5 paralleled by phosphorylation of the enzyme

19 August 2018

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YC-1 potentiates nitric oxide- and carbon monoxide-induced cyclic GMP effects in human platelets.

19 August 2018

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19 August 2018

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19 August 2018

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Crossref

https://api.crossref.org/works/10.1111/J.1476-5381.2010.00977.X

Phosphorylation of phosphodiesterase-5 by cyclic nucleotide-dependent protein kinase alters its catalytic and allosteric cGMP-binding activities

21 January 2018

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12 December 2020

Specificity of cyclic GMP activation of a multi-substrate cyclic nucleotide phosphodiesterase from rat liver

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12 December 2020

Purification and characterization of cyclic GMP-stimulated cyclic nucleotide phosphodiesterase from calf liver. Effects of divalent cations on activity

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12 December 2020

Derivatives of 1-beta-D-ribofuranosylbenzimidazole 3',5'-phosphate that mimic the actions of adenosine 3',5'-phosphate (cAMP) and guanosine 3',5'-phosphate (cGMP)

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12 December 2020

Identification of key amino acids in a conserved cGMP-binding site of cGMP-binding phosphodiesterases. A putative NKXnD motif for cGMP binding

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12 December 2020

ANF elicits phosphorylation of the cGMP phosphodiesterase in vascular smooth muscle cells

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12 December 2020

Structural and functional features in human PDE5A1 regulatory domain that provide for allosteric cGMP binding, dimerization, and regulation

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12 December 2020

Multiple conformations of phosphodiesterase-5: implications for enzyme function and drug development

1 reference

12 December 2020

10.1111/J.1476-5381.2010.00977.X

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20698857 AND SRC:MED&resulttype=core&format=json

9 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20698857 AND SRC:MED&resulttype=core&format=json

9 February 2020

PubMed publication ID

20698857

1 reference