A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs). (Q41475288)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23162754 AND SRC:MED&resulttype=core&format=json

18 February 2020

title

A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs) (English)

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18 February 2020

2

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18 February 2020

author name string

Jennifer D Stone

1

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18 February 2020

Andrea Schietinger

3

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18 February 2020

Hans Schreiber

4

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18 February 2020

David M Kranz

5

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18 February 2020

publication date

1 September 2012

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18 February 2020

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18 February 2020

volume

1

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18 February 2020

issue

6

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18 February 2020

page(s)

863-873

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CAR T cells transform to trucks: chimeric antigen receptor-redirected T cells engineered to deliver inducible IL-12 modulate the tumour stroma to combat cancer

18 February 2020

cites work

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T cell receptor engineering

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T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia

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Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia

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Immunomodulatory therapy of cancer with T cell-engaging BiTE antibody blinatumomab

11 June 2018

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The immunoregulatory mechanisms of carcinoma for its survival and development

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Building better chimeric antigen receptors for adoptive T cell therapy

11 June 2018

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Mathematical modeling of chimeric TCR triggering predicts the magnitude of target lysis and its impairment by TCR downmodulation

11 June 2018

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Features of responding T cells in cancer and chronic infection.

11 June 2018

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Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2

11 June 2018

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Evolving novel anti-HER2 strategies

11 June 2018

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A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity

11 June 2018

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T cell receptor gene therapy for cancer

11 June 2018

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The impact of TCR-binding properties and antigen presentation format on T cell responsiveness

11 June 2018

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Bispecific T-cell engaging antibodies for cancer therapy

11 June 2018

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HER2-targeted therapy in breast cancer. Monoclonal antibodies and tyrosine kinase inhibitors

11 June 2018

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Tumor-specific immune responses

11 June 2018

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Engineering higher affinity T cell receptors using a T cell display system

11 June 2018

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Tumor regression in cancer patients by very low doses of a T cell-engaging antibody

11 June 2018

1 reference

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Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane.

11 June 2018

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Redirected activity of human antitumor chimeric immune receptors is governed by antigen and receptor expression levels and affinity of interaction.

11 June 2018

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Expression of tumor-associated differentiation antigens, MUC1 glycoforms and CEA, in human thymic epithelial cells: implications for self-tolerance and tumor therapy

11 June 2018

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Facilitating matched pairing and expression of TCR chains introduced into human T cells

11 June 2018

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A mutant chaperone converts a wild-type protein into a tumor-specific antigen

11 June 2018

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Cancer regression in patients after transfer of genetically engineered lymphocytes

11 June 2018

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Prospect for anti-HER2 receptor therapy in breast cancer

11 June 2018

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Phase I trial of the trifunctional anti-HER2 x anti-CD3 antibody ertumaxomab in metastatic breast cancer

11 June 2018

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A quantitative exploration of surface antigen expression in common B-cell malignancies using flow cytometry.

11 June 2018

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MT110: a novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors

11 June 2018

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Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma

11 June 2018

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An inducible caspase 9 safety switch for T-cell therapy

11 June 2018

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T cell activation by antibody-like immunoreceptors: increase in affinity of the single-chain fragment domain above threshold does not increase T cell activation against antigen-positive target cells but decreases selectivity.

11 June 2018

1 reference

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Poor immunogenicity of a self/tumor antigen derives from peptide-MHC-I instability and is independent of tolerance

11 June 2018

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Jurkat T cells and development of the T-cell receptor signalling paradigm

11 June 2018

1 reference

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A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3489742

Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3489742

Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3489742

HLA class I antigen abnormalities and immune escape by malignant cells.

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3489742

Plat-E: an efficient and stable system for transient packaging of retroviruses

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3489742

A recombinant bispecific single-chain antibody, CD19 x CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes.

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3489742

Functional balance between T cell chimeric receptor density and tumor associated antigen density: CTL mediated cytolysis and lymphokine production

11 June 2018

1 reference

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Overview of the clinical development of rituximab: first monoclonal antibody approved for the treatment of lymphoma

11 June 2018

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Trastuzumab, a recombinant DNA-derived humanized monoclonal antibody, a novel agent for the treatment of metastatic breast cancer

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3489742

Efficient discrimination between different densities of target antigen by tetracycline-regulatable T bodies

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3489742

Flow cytometric quantitation of immunofluorescence intensity: problems and perspectives. European Working Group on Clinical Cell Analysis

11 June 2018

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Construction and characterisation of a functional CD19 specific single chain Fv fragment for immunotherapy of B lineage leukaemia and lymphoma

11 June 2018

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Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors

11 June 2018

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Natural history of HLA expression during tumour development.

11 June 2018

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A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity

11 June 2018

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Isolation of microtubule protein from cultured mouse neuroblastoma cells

11 June 2018

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Identification of a monoclonal antibody specific for a murine T3 polypeptide

11 June 2018

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Hybrid antibodies can target sites for attack by T cells

11 June 2018

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Tumor antigens defined by cloned immunological probes are highly polymorphic and are not detected on autologous normal cells

11 June 2018

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Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival.

11 June 2018

1 reference

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Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy

19 August 2018

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High frequency of functionally active Melan-a-specific T cells in a patient with progressive immunoproteasome-deficient melanoma

19 August 2018

1 reference

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T-cell clones can be rendered specific for CD19: toward the selective augmentation of the graft-versus-B-lineage leukemia effect

19 August 2018

1 reference

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Quantitative analysis of leukocyte membrane antigen expression: normal adult values

19 August 2018

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Derivation of a T cell hybridoma variant deprived of functional T cell receptor α and β chain transcripts reveals a nonfunctional α-mRNA of BW5147 origin

19 August 2018

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Crossref

https://api.crossref.org/works/10.4161/ONCI.20592

On the species specificity of the interaction of LFA-1 with intercellular adhesion molecules

21 January 2018

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Efficient transfer of a tumor antigen-reactive TCR to human peripheral blood lymphocytes confers anti-tumor reactivity

2 December 2018

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12 December 2020

Quantitative determination of the epidermal growth factor receptor in cervical cancer and normal cervical epithelium by 2-color flow cytometry: Evidence for down-regulation in cervical cancer

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12 December 2020

Targeting mutations predictably

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12 December 2020

Immunotherapy through TCR gene transfer

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12 December 2020

Performance of calibration standards for antigen quantitation with flow cytometry

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12 December 2020

Identifiers

DOI

10.4161/ONCI.20592

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23162754 AND SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23162754 AND SRC:MED&resulttype=core&format=json

18 February 2020

PubMed publication ID

23162754

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23162754 AND SRC:MED&resulttype=core&format=json