Metabolic inhibition of sialyl-Lewis X biosynthesis by 5-thiofucose remodels the cell surface and impairs selectin-mediated cell adhesion. (Q41461652)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23019334 AND SRC:MED&resulttype=core&format=json

9 March 2020

title

Metabolic inhibition of sialyl-Lewis X biosynthesis by 5-thiofucose remodels the cell surface and impairs selectin-mediated cell adhesion (English)

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9 March 2020

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Jayakanthan Kumarasamy

2

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9 March 2020

David J Vocadlo

4

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9 March 2020

author name string

Wesley F Zandberg

1

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9 March 2020

B Mario Pinto

3

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9 March 2020

language of work or name

English

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publication date

27 September 2012

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23019334 AND SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

9 March 2020

published in

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9 March 2020

volume

287

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9 March 2020

issue

47

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9 March 2020

page(s)

40021-40030

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Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome

9 March 2020

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11 June 2018

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11 June 2018

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A disaccharide precursor of sialyl Lewis X inhibits metastatic potential of tumor cells.

11 June 2018

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11 June 2018

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Targeted proteo-glycomics analysis of Sialyl Lewis X antigen expressing glycoproteins secreted by human hepatoma cell line

11 June 2018

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Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1

11 June 2018

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Expression of human alpha(1,3)fucosyltransferase antisense sequences inhibits selectin-mediated adhesion and liver metastasis of colon carcinoma cells.

11 June 2018

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Affinity of 5-thio-L-fucose-containing Lewis X (LeX) trisaccharide analogs to anti-LeX monoclonal antibody

11 June 2018

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11 June 2018

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In vivo specificity of human alpha1,3/4-fucosyltransferases III-VII in the biosynthesis of LewisX and Sialyl LewisX motifs on complex-type N-glycans. Coexpression studies from bhk-21 cells together with human beta-trace protein

11 June 2018

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Molecular Cloning of Human GDP-mannose 4,6-Dehydratase and Reconstitution of GDP-fucose Biosynthesis in Vitro

11 June 2018

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Carbohydrate-mediated cell adhesion involved in hematogenous metastasis of cancer.

11 June 2018

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Elevation of an alpha(1,3)fucosyltransferase activity correlated with apoptosis in the human colon adenocarcinoma cell line, HT-29.

11 June 2018

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11 June 2018

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11 June 2018

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11 June 2018

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11 June 2018

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11 June 2018

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11 June 2018

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11 June 2018

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11 June 2018

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11 June 2018

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The biosynthesis of the selectin-ligand sialyl Lewis x in colorectal cancer tissues is regulated by fucosyltransferase VI and can be inhibited by an RNA interference-based approach

11 June 2018

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19 August 2018

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19 August 2018

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Discontinuation of fucose therapy in LADII causes rapid loss of selectin ligands and rise of leukocyte counts

19 August 2018

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Transfection of alpha(1,3)fucosyltransferase antisense sequences impairs the proliferative and tumorigenic ability of human colon carcinoma cells.

19 August 2018

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12 December 2020

Increased expression of sialyl-dimeric LeX antigen in liver metastases of human colorectal carcinoma

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12 December 2020

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Up-regulation of Lewis enzyme (Fuc-TIII) and plasma-type alpha1,3fucosyltransferase (Fuc-TVI) expression determines the augmented expression of sialyl Lewis x antigen in non-small cell lung cancer

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The α(1,3)Fucosyltransferase Fuc-TVII Controls Leukocyte Trafficking through an Essential Role in L-, E-, and P-selectin Ligand Biosynthesis

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Identifiers

DOI

10.1074/JBC.M112.403568

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23019334 AND SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23019334 AND SRC:MED&resulttype=core&format=json

9 March 2020

PubMed publication ID

23019334

1 reference