Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase. (Q41257359)

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27 March 2020

title

Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase (English)

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27 March 2020

1

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27 March 2020

Marta Carroni

2

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27 March 2020

Maya Topf

4

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27 March 2020

Bernd Bukau

5

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27 March 2020

Axel Mogk

6

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27 March 2020

Helen Saibil

7

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27 March 2020

3

Kamila B Franke

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27 March 2020

publication date

4 August 2017

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27 March 2020

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27 March 2020

volume

3

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27 March 2020

issue

8

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27 March 2020

page(s)

e1701726

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Mechanism of Vps4 hexamer function revealed by cryo-EM

27 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Structural basis for the disaggregase activity and regulation of Hsp104.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Refinement of atomic models in high resolution EM reconstructions using Flex-EM and local assessment.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Mechanistic insights into bacterial AAA proteases and protein-remodelling machines

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

ClpB N-terminal domain plays a regulatory role in protein disaggregation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

TEMPy: a Python library for assessment of three-dimensional electron microscopy density fits

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Mechanistic insights into the recycling machine of the SNARE complex

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Heat shock protein (Hsp) 70 is an activator of the Hsp104 motor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

RELION: implementation of a Bayesian approach to cryo-EM structure determination

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

ClpX(P) generates mechanical force to unfold and translocate its protein substrates

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

PHENIX: a comprehensive Python-based system for macromolecular structure solution

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Hsp104 and ClpB: protein disaggregating machines

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Protein structure fitting and refinement guided by cryo-EM density

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Visualizing the ATPase cycle in a protein disaggregating machine: structural basis for substrate binding by ClpB

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

The structure of ClpB: a molecular chaperone that rescues proteins from an aggregated state

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Ratchet-like polypeptide translocation mechanism of the AAA disaggregase Hsp104.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Structure of a AAA unfoldase in the process of unfolding substrate.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Mutant Analysis Reveals Allosteric Regulation of ClpB Disaggregase

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Substrate-translocating loops regulate mechanochemical coupling and power production in AAA protease ClpXP

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

The heat-shock protein ClpB in Escherichia coli is a protein-activated ATPase

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

CTFFIND4: Fast and accurate defocus estimation from electron micrographs.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

iMODFIT: efficient and robust flexible fitting based on vibrational analysis in internal coordinates

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Unraveling the mechanism of protein disaggregation through a ClpB-DnaK interaction.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Disruption of ionic interactions between the nucleotide binding domain 1 (NBD1) and middle (M) domain in Hsp100 disaggregase unleashes toxic hyperactivity and partial independence from Hsp70.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

A tightly regulated molecular toggle controls AAA disaggregase.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Hsp70 proteins bind Hsp100 regulatory M domains to activate AAA disaggregase at aggregate surfaces.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Protein disaggregation by the AAA chaperone ClpB involves partial threading of looped polypeptide segments.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Loops in the central channel of ClpA chaperone mediate protein binding, unfolding, and translocation

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Evidence for an unfolding/threading mechanism for protein disaggregation by Saccharomyces cerevisiae Hsp104.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Characterization of a trap mutant of the AAA chaperone ClpB.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Dynamics of substrate denaturation and translocation by the ClpXP degradation machine

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5544394

Comparative Protein Structure Modeling Using MODELLER.

19 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1126/SCIADV.1701726

21 January 2018

Identifiers

DOI

10.1126/SCIADV.1701726

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28798962 AND SRC:MED&resulttype=core&format=json

27 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28798962 AND SRC:MED&resulttype=core&format=json

27 March 2020

PubMed publication ID

28798962

1 reference