Dystrophin (Q412285)

WW domain superfamily

1 reference

EF-hand domain pair

1 reference

auxiliary protein involved in transmembrane transport

1 reference

Transporter Classification Database ID

8.A.66.1.2

2 October 2019

hierarchical database ID heuristic

Zinc finger, ZZ-type, protein family

1 reference

EF-hand domain, type 2, protein family

1 reference

EF-hand domain, type 1, protein family

1 reference

Calponin homology domain, protein family

1 reference

WW domain, protein family

1 reference

Actinin-type actin-binding domain, conserved site, protein family

1 reference

Spectrin repeat, protein family

1 reference

Spectrin/alpha-actinin, protein family

1 reference

time of discovery or invention

mass

427 kilodalton

0 references

1987

0 references

1 reference

13 November 2019

1 reference

13 November 2019

nitric-oxide synthase binding

1 reference

8 April 2019

Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

vinculin binding

1 reference

8 April 2019

Role of dystrophins and utrophins in platelet adhesion process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

myosin binding

1 reference

8 April 2019

Role of dystrophins and utrophins in platelet adhesion process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

zinc ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

1 reference

8 April 2019

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

1 reference

8 April 2019

protein binding

8 references

8 April 2019

Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

8 April 2019

Interactions of intermediate filament protein synemin with dystrophin and utrophin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

8 April 2019

Syntrophin binds to an alternatively spliced exon of dystrophin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

8 April 2019

Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

8 April 2019

The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

8 April 2019

Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

actin binding

The 'spectraplakins': cytoskeletal giants with characteristics of both spectrin and plakin families

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

8 April 2019

8 April 2019

Role of dystrophins and utrophins in platelet adhesion process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

structural constituent of muscle

structural constituent of cytoskeleton

1 reference

8 April 2019

The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

1 reference

8 April 2019

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

1 reference

8 April 2019

postsynaptic membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

1 reference

8 April 2019

lateral plasma membrane

1 reference

8 April 2019

SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

1 reference

8 April 2019

filopodium

1 reference

8 April 2019

Role of dystrophins and utrophins in platelet adhesion process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

cell-substrate junction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

dystrophin-associated glycoprotein complex

Dystrophin: the long and short of it

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

8 April 2019

Identification and characterization of the dystrophin anchoring site on beta-dystroglycan

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

NAS

8 April 2019

Expression of the dystrophin-glycoprotein complex is a marker for human airway smooth muscle phenotype maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

cell surface

1 reference

8 April 2019

Aciculin and its relation to dystrophin: immunocytochemical studies in human normal and Duchenne dystrophy quadriceps muscles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

cell junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

1 reference

8 April 2019

Z discdkac

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

actin cytoskeleton

1 reference

27 March 2018

Dystrophin Dp71: the smallest but multifunctional product of the Duchenne muscular dystrophy gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11532&geneProductId=UniProtKB:P11532

sarcolemma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

3 references

8 April 2019

8 April 2019

Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

8 April 2019

Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

costamere

1 reference

8 April 2019

Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

syntrophin complex

1 reference

8 April 2019

SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

neuron projection terminus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

filopodium membrane

1 reference

8 April 2019

Role of dystrophins and utrophins in platelet adhesion process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

protein-containing complex

1 reference

8 April 2019

Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

1 reference

8 April 2019

membrane raft

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

response to muscle stretch

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

regulation of ryanodine-sensitive calcium-release channel activity

1 reference

8 April 2019

Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

regulation of voltage-gated calcium channel activity

1 reference

8 April 2019

Voltage-gated ion channel dysfunction precedes cardiomyopathy development in the dystrophic heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

cardiac muscle contraction

1 reference

8 April 2019

High incidence of electrocardiogram abnormalities in young patients with duchenne muscular dystrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

muscle cell cellular homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

1 reference

8 April 2019

Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

peptide biosynthetic process

1 reference

8 April 2019

Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

muscle organ development

NAS

1 reference

8 April 2019

Expression of recombinant dystrophin and its localization to the cell membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

NAS

regulation of heart rate

1 reference

8 April 2019

High incidence of electrocardiogram abnormalities in young patients with duchenne muscular dystrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

positive regulation of neuron differentiation

1 reference

27 March 2018

Dystrophin Dp71 is required for neurite outgrowth in PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11532&geneProductId=UniProtKB:P11532

negative regulation of peptidyl-serine phosphorylation

1 reference

8 April 2019

Hierarchical accumulation of RyR post-translational modifications drives disease progression in dystrophic cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

positive regulation of neuron projection development

1 reference

27 March 2018

Dystrophin Dp71 is required for neurite outgrowth in PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11532&geneProductId=UniProtKB:P11532

muscle filament sliding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

1 reference

8 April 2019

positive regulation of sodium ion transmembrane transporter activity

1 reference

8 April 2019

Voltage-gated ion channel dysfunction precedes cardiomyopathy development in the dystrophic heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

regulation of cellular response to growth factor stimulus

1 reference

27 March 2018

Dystrophin Dp71 is required for neurite outgrowth in PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11532&geneProductId=UniProtKB:P11532

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

1 reference

8 April 2019

Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

motile cilium assembly

1 reference

27 March 2018

Dystrophin Dp71: the smallest but multifunctional product of the Duchenne muscular dystrophy gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11532&geneProductId=UniProtKB:P11532

regulation of skeletal muscle contraction

1 reference

8 April 2019

Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion

1 reference

8 April 2019

Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

cytoskeleton organization

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11532

http://purl.uniprot.org/uniprot/P11532

length

150 nanometre

0 references

Gene Atlas image

PBB GE DMD 203881 s at fs.png
732 × 530; 10 KB

0 references

exact match

1 reference

Identifiers.org

has part(s)

Spectrin/alpha-actinin

1 reference

WW domain

1 reference

Spectrin repeat

1 reference

Zinc finger, ZZ-type

1 reference

EF-hand domain, type 1

1 reference

EF-hand domain, type 2

1 reference

Calponin homology domain

1 reference

Actinin-type actin-binding domain, conserved site

1 reference

https://docs.openalex.org/download-snapshot/snapshot-data-format

Commons category

Dystrophin

0 references

Identifiers

MeSH descriptor ID

D016189

subject named as

Dystrophin

0 references

0 references

0 references

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

Transporter Classification Database ID

English

8.A.66.1.2

2 references

Transporter Classification database

13 March 2020

Transporter Classification database