A novel antifolate resistance gene on the amplified H circle of Leishmania. (Q41096055)

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15 September 2019

title

A novel antifolate resistance gene on the amplified H circle of Leishmania (English)

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15 September 2019

author name string

Papadopoulou B

series ordinal

1

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15 September 2019

Roy G

series ordinal

2

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15 September 2019

Ouellette M

series ordinal

3

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15 September 2019

language of work or name

English

0 references

publication date

1 October 1992

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15 September 2019

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15 September 2019

volume

11

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15 September 2019

issue

10

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15 September 2019

page(s)

3601-3608

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Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica

15 September 2019

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1 reference

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Crystal structure of a novel trimethoprim-resistant dihydrofolate reductase specified in Escherichia coli by R-plasmid R67.

26 September 2017

1 reference

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Amplified DNAs in laboratory stocks of Leishmania tarentolae: extrachromosomal circles structurally and functionally similar to the inverted-H-region amplification of methotrexate-resistant Leishmania major

26 September 2017

1 reference

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Nucleotide sequence of Rhizobium meliloti RCR2011 genes involved in host specificity of nodulation

26 September 2017

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A growth factor-repressible gene associated with protein kinase C-mediated inhibition of adipocyte differentiation

26 September 2017

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Purification and structural characterization of placental NAD( )-linked 15-hydroxyprostaglandin dehydrogenase. The primary structure reveals the enzyme to belong to the short-chain alcohol dehydrogenase family

26 September 2017

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Stable transfection of the human parasite Leishmania major delineates a 30-kilobase region sufficient for extrachromosomal replication and expression

26 September 2017

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Stable expression of the bacterial neor gene in Leishmania enriettii

26 September 2017

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Site-directed mutagenesis of the conserved tyrosine 151 of human placental NAD( )-dependent 15-hydroxyprostaglandin dehydrogenase yields a catalytically inactive enzyme

26 September 2017

1 reference

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The amplified H circle of methotrexate-resistant leishmania tarentolae contains a novel P-glycoprotein gene

26 September 2017

1 reference

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Drug resistance and P-glycoprotein gene amplification in the protozoan parasite Leishmania

26 September 2017

1 reference

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Three-dimensional structure of holo 3 alpha,20 beta-hydroxysteroid dehydrogenase: a member of a short-chain dehydrogenase family

26 September 2017

1 reference

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Characteristics of short-chain alcohol dehydrogenases and related enzymes

26 September 2017

1 reference

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Gene amplification in Leishmania

26 September 2017

1 reference

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Direct and inverted DNA repeats associated with P-glycoprotein gene amplification in drug resistant Leishmania.

26 September 2017

1 reference

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Gene expression in Leishmania: analysis of essential 5' DNA sequences

26 September 2017

1 reference

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DNA sequencing with chain-terminating inhibitors

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556819

Unstable DNA amplifications in methotrexate-resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556819

Reductions in methotrexate and folate influx in methotrexate-resistant lines of Leishmania major are independent of R or H region amplification.

17 June 2018

1 reference

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Methotrexate-resistant Leishmania donovani genetically deficient in the folate-methotrexate transporter

17 June 2018

1 reference

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The H circles of Leishmania tarentolae are a unique amplifiable system of oligomeric DNAs associated with drug resistance.

17 June 2018

1 reference

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Extrachromosomal elements in the lower eukaryote Leishmania.

17 June 2018

1 reference

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Multiple drug resistance and conservative amplification of the H region in Leishmania major

17 June 2018

1 reference

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H DNA amplification in Leishmania resistant to both arsenite and methotrexate.

17 June 2018

1 reference

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Toluene degradation by Pseudomonas putida F1. Nucleotide sequence of the todC1C2BADE genes and their expression in Escherichia coli

17 June 2018

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Wild-type and drug-resistant Leishmania major hydrolyze methotrexate to N-10-methyl-4-deoxy-4-aminopteroate without accumulation of methotrexate polyglutamates

17 June 2018

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The presence and distribution of reduced folates in Escherichia coli dihydrofolate reductase mutants.

17 June 2018

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Targeted insertion of the neomycin phosphotransferase gene into the tubulin gene cluster of Trypanosoma brucei.

17 June 2018

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Heavy metal resistance: a new role for P-glycoproteins in Leishmania

17 June 2018

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Activation of trypanosome surface glycoprotein genes involves a duplication-transposition leading to an altered 3' end

17 June 2018

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12 December 2020

Extended superfamily of short alcohol-polyol-sugar dehydrogenases: structural similarities between glucose and ribitol dehydrogenases

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12 December 2020

Pseudomonas 3 beta-hydroxysteroid dehydrogenase. Primary structure and relationships to other steroid dehydrogenases

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12 December 2020

Nucleotide sequence, transcription and deduced function of a gene involved in polyketide antibiotic synthesis in Streptomyces coelicolor

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DNA amplification in arsenite-resistant Leishmania

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12 December 2020

10.1002/J.1460-2075.1992.TB05444.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1396560 AND SRC:MED&resulttype=core&format=json

15 September 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1396560 AND SRC:MED&resulttype=core&format=json

15 September 2019

PubMed publication ID

1396560

1 reference