The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch. (Q41069471)

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6 March 2020

title

The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch (English)

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6 March 2020

0 references

3

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6 March 2020

author name string

Sandeep K Talapatra

series ordinal

1

1 reference

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6 March 2020

Bethany Harker

series ordinal

2

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6 March 2020

language of work or name

English

0 references

publication date

27 April 2015

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6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25915621 AND SRC:MED&resulttype=core&format=json

6 March 2020

volume

4

1 reference

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Nucleotide exchange in dimeric MCAK induces longitudinal and lateral stress at microtubule ends to support depolymerization.

6 March 2020

cites work

1 reference

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Aurora B inhibits MCAK activity through a phosphoconformational switch that reduces microtubule association

26 September 2017

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The molecular basis for kinesin functional specificity during mitosis.

26 September 2017

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A second tubulin binding site on the kinesin-13 motor head domain is important during mitosis

26 September 2017

1 reference

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Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases

26 September 2017

1 reference

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The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle.

26 September 2017

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Mitotic centromere-associated kinesin (MCAK) mediates paclitaxel resistance

26 September 2017

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The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of Autoinhibition

26 September 2017

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PLK1 phosphorylates mitotic centromere-associated kinesin and promotes its depolymerase activity

26 September 2017

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Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres

26 September 2017

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Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface

26 September 2017

1 reference

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Functional and spatial regulation of mitotic centromere-associated kinesin by cyclin-dependent kinase 1.

26 September 2017

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

26 September 2017

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26 September 2017

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Catalysis of the microtubule on-rate is the major parameter regulating the depolymerase activity of MCAK.

26 September 2017

1 reference

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A new model for binding of kinesin 13 to curved microtubule protofilaments

26 September 2017

1 reference

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Half-site inhibition of dimeric kinesin head domains by monomeric tail domains

26 September 2017

1 reference

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Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity

26 September 2017

1 reference

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Aurora B phosphorylates multiple sites on mitotic centromere-associated kinesin to spatially and temporally regulate its function

26 September 2017

1 reference

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The conserved KMN network constitutes the core microtubule-binding site of the kinetochore

26 September 2017

1 reference

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The interplay of the N- and C-terminal domains of MCAK control microtubule depolymerization activity and spindle assembly

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443670

The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443670

Kinesin 5-independent poleward flux of kinetochore microtubules in PtK1 cells

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443670

Full-length dimeric MCAK is a more efficient microtubule depolymerase than minimal domain monomeric MCAK

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443670

MCAK associates with the tips of polymerizing microtubules

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443670

Functionally distinct kinesin-13 family members cooperate to regulate microtubule dynamics during interphase.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443670

The CCP4 suite: programs for protein crystallography

26 September 2017

1 reference

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Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation.

26 September 2017

1 reference

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Structure of a kinesin microtubule depolymerization machine.

26 September 2017

1 reference

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A common mechanism for microtubule destabilizers-M type kinesins stabilize curling of the protofilament using the class-specific neck and loops

26 September 2017

1 reference

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Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity

26 September 2017

1 reference

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Aurora B regulates MCAK at the mitotic centromere

26 September 2017

1 reference

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Regulation of KinI kinesin ATPase activity by binding to the microtubule lattice

26 September 2017

1 reference

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K-loop insertion restores microtubule depolymerizing activity of a "neckless" MCAK mutant

26 September 2017

1 reference

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XKCM1 acts on a single protofilament and requires the C terminus of tubulin

26 September 2017

1 reference

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Molecular dissection of the microtubule depolymerizing activity of mitotic centromere-associated kinesin

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443670

Engineering the processive run length of the kinesin motor

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443670

The C-terminus of tubulin increases cytoplasmic dynein and kinesin processivity

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443670

Single-molecule analysis of kinesin motility reveals regulation by the cargo-binding tail domain

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443670

ESPript: analysis of multiple sequence alignments in PostScript

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443670

Ligand-dependent conformational equilibria of serum albumin revealed by tryptophan fluorescence quenching

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443670

Mitotic Centromere–associated Kinesin Is Important for Anaphase Chromosome Segregation

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443670

XKCM1: a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443670

Overexpression of Mitotic Centromere–Associated Kinesin Stimulates Microtubule Detachment and Confers Resistance to Paclitaxel

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443670

Protein complex expression by using multigene baculoviral vectors

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443670

C-terminus of mitotic centromere-associated kinesin (MCAK) inhibits its lattice-stimulated ATPase activity

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443670

Phosphorylation relieves autoinhibition of the kinetochore motor Cenp-E.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443670

A mechanism for microtubule depolymerization by KinI kinesins

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443670

Kinesin's IAK tail domain inhibits initial microtubule-stimulated ADP release.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443670

Kinesin's tail domain is an inhibitory regulator of the motor domain

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443670

Microtubule-depolymerizing kinesins

19 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25915621

12 December 2020

inferred from PubMed ID database lookup

Formation of the compact confomer of kinesin requires a COOH-terminal heavy chain domain and inhibits microtubule-stimulated ATPase activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25915621

12 December 2020

inferred from PubMed ID database lookup

Depolymerizing kinesins Kip3 and MCAK shape cellular microtubule architecture by differential control of catastrophe.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25915621

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.7554/ELIFE.06421

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25915621 AND SRC:MED&resulttype=core&format=json

release_43fldkkb2jfpxnlaj5sqxsn374

6 March 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/43fldkkb2jfpxnlaj5sqxsn374

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25915621 AND SRC:MED&resulttype=core&format=json

6 March 2020

PubMed publication ID

25915621

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25915621 AND SRC:MED&resulttype=core&format=json