Aromatase inhibitors--mechanisms of steroidal inhibitors (Q41053025)

26 September 2017

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title

Aromatase inhibitors--mechanisms of steroidal inhibitors (English)

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26 September 2017

R W Brueggemeier

1

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26 September 2017

language of work or name

English

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publication date

1 January 1994

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Breast Cancer Research and Treatment

26 September 2017

published in

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26 September 2017

volume

30

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26 September 2017

issue

1

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26 September 2017

page(s)

31-42

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7 alpha-substituted derivatives of androstenedione as inhibitors of estrogen biosynthesis

26 September 2017

cites work

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12 December 2020

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12 December 2020

Studies on aromatase inhibition with 4-androstene-3,6,17-trione: its 3 beta-reduction and time-dependent irreversible binding to aromatase with human placental microsomes

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12 December 2020

Inactivation of human placental aromatase by 6 alpha- and 6 beta-hydroperoxyandrostenedione

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12 December 2020

Biochemical and molecular aspects of aromatase

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12 December 2020

Interactions of thiol-containing androgens with human placental aromatase

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12 December 2020

Effects of aromatase inhibitors, aminoglutethimide, and 4-hydroxyandrostenedione on cyclic rats and rats with 7,12-dimethylbenz(a)anthracene-induced mammary tumors

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12 December 2020

Potent enzyme-activated inhibition of aromatase by a 7 alpha-substituted C19 steroid

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12 December 2020

1-Methyl-1,4-androstadiene-3,17-dione (SH 489): characterization of an irreversible inhibitor of estrogen biosynthesis

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12 December 2020

Synthesis and biochemical studies of 7-substituted 4,6-androstadiene-3,17-diones as aromatase inhibitors

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12 December 2020

Endocrine treatment of breast cancer in women

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12 December 2020

3 beta-hydroxyandrost-4-en-6-one derivatives as aromatase inhibitors

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12 December 2020

Inhibitory effect of combined treatment with the aromatase inhibitor exemestane and tamoxifen on DMBA-induced mammary tumors in rats

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12 December 2020

Enzyme-generated intermediates derived from 4-androstene-3,6,17-trione and 1,4,6-androstatriene-3,17-dione cause a time-dependent decrease in human placental aromatase activity

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12 December 2020

Aromatase inhibition in hypophysectomised female rats: a novel animal model for in vivo screening

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12 December 2020

4-Hydroxyandrostenedione in treatment of postmenopausal patients with advanced breast cancer

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12 December 2020

Synthesis and biochemical studies of 7 alpha-substituted androsta-1,4-diene-3,17-diones as enzyme-activated irreversible inhibitors of aromatase

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12 December 2020

A-ring bridged steroids as potent inhibitors of aromatase

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12 December 2020

Aromatase inhibition by 7-substituted steroids in human choriocarcinoma cell culture

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12 December 2020

Time-dependent inhibition of aromatase in trophoblastic tumor cells in tissue culture

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12 December 2020

Biological characterization of 10-(2-propynyl) estr-4-ene-3, 17-dione (MDL 18,962), an enzyme-activated inhibitor of aromatase

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12 December 2020

Synthesis and evaluation of 10 beta-substituted 4-estrene-3, 17-diones as inhibitors of human placental microsomal aromatase

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12 December 2020

3-Methylene-substituted androgens as novel aromatization inhibitors. Evidence of a requirement for C-3 oxygen in C-19 hydroxylations

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12 December 2020

4-Aminoandrostenedione derivatives: a novel class of irreversible aromatase inhibitors. Comparison with FCE 24304 and 4-hydroxyandrostenedione

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12 December 2020

Tissue-specific promoters regulate aromatase cytochrome P450 expression

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12 December 2020

Recent developments in aromatase inhibition as a potential treatment for oestrogen-dependent breast cancer.

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12 December 2020

Effects of the aromatase inhibitor 7 alpha-(4'-amino)phenylthio-4-androstene-3,17-dione in MCF-7 human mammary carcinoma cell culture

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12 December 2020

Covalent modification of aromatase by a radiolabeled irreversible inhibitor

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12 December 2020

Inhibition of aromatase activity and of endocrine-responsive tumor growth by 10-propargylestr-4-ene-3, 17-dione and its 17-propionate derivative

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12 December 2020

Structure-activity relationships for non-steroidal inhibitors of aromatase

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12 December 2020

Studies on the mechanism of estrogen biosynthesis. 8. The development of inhibitors of the enzyme system in human placenta

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12 December 2020

Steroidal inhibitors as chemical probes of the active site of aromatase

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12 December 2020

7-substituted 1,4,6-androstatriene-3,17-diones as enzyme-activated irreversible inhibitors of aromatase

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12 December 2020

Treatment of advanced postmenopausal breast cancer with an aromatase inhibitor, 4-hydroxyandrostenedione: phase II report

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12 December 2020

Synthesis and evaluation of 4-(substituted thio)-4-androstene-3,17-dione derivatives as potential aromatase inhibitors

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12 December 2020

7-substituted steroidal aromatase inhibitors: structure-activity relationships and molecular modeling

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12 December 2020

Inhibition of estrogen biosynthesis through steroids

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12 December 2020

Substituted C19 steroid analogs as inhibitors of aromatase

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12 December 2020

Active-site-directed inactivation of aromatase from human placental microsomes by brominated androgen derivatives

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12 December 2020

7 alpha-substituted androstenediones as effective in vitro and in vivo inhibitors of aromatase

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12 December 2020

Aromatase enzyme catalysis is involved in the potent inhibition of estrogen biosynthesis caused by 4-acetoxy- and 4-hydroxy-4-androstene-3, 17-dione

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12 December 2020

Novel time-dependent inhibitors of human placental aromatase

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12 December 2020

Inhibition of Peripheral Aromatization in Baboons by an Enzyme-Activated Aromatase Inhibitor (MDL 18,962)*

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12 December 2020

Time-dependent inhibition of human placental aromatase with a 2,19-methyleneoxy-bridged androstenedione

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12 December 2020

Synthesis and biochemical evaluation of inhibitors of estrogen biosynthesis

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12 December 2020

Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo

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12 December 2020

Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells

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12 December 2020

A new irreversible aromatase inhibitor, 6-methylenandrosta-1,4-diene-3,17-dione (FCE 24304): antitumor activity and endocrine effects in rats with DMBA-induced mammary tumors

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12 December 2020

10 beta-propynyl-substituted steroids. Mechanism-based enzyme-activated irreversible inhibitors of estrogen biosynthesis.

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12 December 2020

Inhibition of aromatase cytochrome P-450 by 10-oxirane and 10-thiirane substituted androgens. Implications for the structure of the active site

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12 December 2020

The Effect of an Aromatase Inhibitor, 4-Hydroxy-4-Androstene- 3,17-Dione, On Estrogen-Dependent Processes in Reproduction and Breast Cancer11

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12 December 2020

6-Methylenandrosta-1,4-diene-3,17-dione (FCE 24304): a new irreversible aromatase inhibitor

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12 December 2020

Inhibition and inactivation of estrogen synthetase (aromatase) by fluorinated substrate analogues

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12 December 2020

Stereoselective inhibition of human placental aromatase

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12 December 2020

Effects of aromatase inhibitor 4-hydroxyandrostenedione and other compounds in the 7, 12-dimethylbenz(a)anthracene-induced breast carcinoma model.

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12 December 2020

Biological characterization of A-ring steroids

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12 December 2020

Biochemical and endocrine properties of a mechanism-based inhibitor of aromatase

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12 December 2020

Effects of the aromatase inhibitor 7 alpha-(4'-amino)phenylthio-4-androstene-3,17-dione on 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats

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12 December 2020

Thiol-containing androgens as suicide substrates of aromatase

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12 December 2020

Studies of human placental aromatase

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12 December 2020

Aromatase inhibitors. Synthesis and biological activity of androstenedione derivatives

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12 December 2020

Identifiers

DOI

10.1007/BF00682739

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Dimensions Publication ID

26 September 2017

1049633982

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