Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1-42-mediated cytotoxicity (Q41016698)

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9 April 2020

title

Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1-42-mediated cytotoxicity (English)

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9 April 2020

5

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9 April 2020

author name string

Ryan T Cameron

1

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9 April 2020

Ellanor Whiteley

2

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9 April 2020

Jon P Day

3

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9 April 2020

Anna I Parachikova

4

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9 April 2020

publication date

5 December 2016

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9 April 2020

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9 April 2020

volume

7

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9 April 2020

issue

1

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9 April 2020

page(s)

64-73

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The amyloid hypothesis of Alzheimer's disease at 25 years

9 April 2020

cites work

1 reference

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Global and local missions of cAMP signaling in neural plasticity, learning, and memory

26 September 2017

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The phosphorylation of Hsp20 enhances its association with amyloid-β to increase protection against neuronal cell death.

26 September 2017

1 reference

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Advances in targeting cyclic nucleotide phosphodiesterases

26 September 2017

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Modulating nitric oxide signaling in the CNS for Alzheimer's disease therapy

26 September 2017

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Blockade of Ser16-Hsp20 phosphorylation attenuates neuroprotection dependent upon Bcl-2 and Bax.

26 September 2017

1 reference

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Phosphodiesterases as therapeutic targets for Alzheimer's disease

26 September 2017

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Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a selective brain penetrant PDE9A inhibitor for the treatment of cognitive

26 September 2017

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The A-kinase-anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser(16).

26 September 2017

1 reference

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Impedance measurement for real time detection of neuronal cell death.

26 September 2017

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Phosphodiesterases in the central nervous system: implications in mood and cognitive disorders

26 September 2017

1 reference

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The emerging role of HSP20 as a multifunctional protective agent

26 September 2017

1 reference

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The role of CREB signaling in Alzheimer's disease and other cognitive disorders.

26 September 2017

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Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes

26 September 2017

1 reference

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Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure

26 September 2017

1 reference

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Cyclic GMP and nitric oxide synthase in aging and Alzheimer's disease.

26 September 2017

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KMUP-1 attenuates serum deprivation-induced neurotoxicity in SH-SY5Y cells: roles of PKG, PI3K/Akt and Bcl-2/Bax pathways.

26 September 2017

1 reference

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Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5221464

Quantitative colocalization analysis of multicolor confocal immunofluorescence microscopy images: pushing pixels to explore biological phenomena

26 September 2017

1 reference

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Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins

26 September 2017

1 reference

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Targeted disruption of the heat shock protein 20-phosphodiesterase 4D (PDE4D) interaction protects against pathological cardiac remodelling in a mouse model of hypertrophy.

26 September 2017

1 reference

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PDE9A inhibition rescues amyloid beta-induced deficits in synaptic plasticity and cognition

17 June 2018

1 reference

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Real-time probing of β-amyloid self-assembly and inhibition using fluorescence self-quenching between neighbouring dyes

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5221464

Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25-35 or Aβ1-40 peptide in rats

19 August 2018

1 reference

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Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model.

19 August 2018

1 reference

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Small heat shock proteins inhibit amyloid-beta protein aggregation and cerebrovascular amyloid-beta protein toxicity

19 August 2018

1 reference

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Specific association of small heat shock proteins with the pathological hallmarks of Alzheimer's disease brains

19 August 2018

1 reference

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Sildenafil-induced vasorelaxation is associated with increases in the phosphorylation of the heat shock-related protein 20 (HSP20).

19 August 2018

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19 August 2018

Identifiers

DOI

10.1002/2211-5463.12156

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28097089 AND SRC:MED&resulttype=core&format=json

9 April 2020

1 reference

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9 April 2020

PubMed publication ID

28097089

1 reference