Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors (Q40971832)

25 September 2017

Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors (English)

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25 September 2017

11

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3 June 2020

Liang Tao

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3 June 2020

Ronnie Berntsson

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3 June 2020

SunHyun Park

5

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3 June 2020

2

Lisheng Peng

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7

Christopher Boone

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3 June 2020

author name string

Sai Man Liu

4

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3 June 2020

Feifan Yu

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3 June 2020

Shilpa Palan

8

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3 June 2020

Matthew Beard

9

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3 June 2020

Pierre-Etienne Chabrier

10

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3 June 2020

Johannes Krupp

12

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3 June 2020

Min Dong

13

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3 June 2020

language of work or name

English

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publication date

3 July 2017

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25 September 2017

Nature Communications

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3 June 2020

volume

8

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3 June 2020

issue

1

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3 June 2020

page(s)

53

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Creative Commons Attribution 4.0 International

3 June 2020

copyright license

start time

3 July 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Clinical differences between botulinum neurotoxin type A and B.

1 reference

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Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins

25 September 2017

1 reference

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Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

25 September 2017

1 reference

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Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A

25 September 2017

1 reference

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Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain.

25 September 2017

1 reference

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Engineered botulinum neurotoxins as new therapeutics

25 September 2017

1 reference

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Engineering Clostridia Neurotoxins with elevated catalytic activity

25 September 2017

1 reference

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Crystal Structures of Botulinum Neurotoxin DC in Complex with Its Protein Receptors Synaptotagmin I and II

25 September 2017

1 reference

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Structure of dual receptor binding to botulinum neurotoxin B

25 September 2017

1 reference

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Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: increased therapeutic dosage and immunogenicity

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Botulinum Neurotoxin D Uses Synaptic Vesicle Protein SV2 and Gangliosides as Receptors

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Botulinum neurotoxin: a marvel of protein design

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Engineering botulinum neurotoxin to extend therapeutic intervention.

25 September 2017

1 reference

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Glycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype F

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Cell entry strategy of clostridial neurotoxins

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Neuro-exocytosis: botulinum toxins as inhibitory probes and versatile therapeutics

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Membrane fusion: grappling with SNARE and SM proteins

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Mechanism of botulinum neurotoxin B and G entry into hippocampal neurons

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Synaptotagmin-2 is essential for survival and contributes to Ca2 triggering of neurotransmitter release in central and neuromuscular synapses

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Structural basis of cell surface receptor recognition by botulinum neurotoxin B

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Molecular anatomy of a trafficking organelle

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

SNAREs--engines for membrane fusion

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

SV2 is the protein receptor for botulinum neurotoxin A.

25 September 2017

1 reference

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Botulinal neurotoxins: revival of an old killer

25 September 2017

1 reference

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Botulinum toxin: a successful therapeutic protein

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Neurotoxins affecting neuroexocytosis

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Clostridial toxins as therapeutic agents: benefits of nature's most toxic proteins

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Safety and efficacy of NeuroBloc (botulinum toxin type B) in type A-resistant cervical dystonia

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

A bacterial two-hybrid system based on a reconstituted signal transduction pathway

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Cleavage of members of the synaptobrevin/VAMP family by types D and F botulinal neurotoxins and tetanus toxin

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Genetic diversity within the botulinum neurotoxin-producing bacteria and their neurotoxins.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Novel chimeras of botulinum neurotoxins A and E unveil contributions from the binding, translocation, and protease domains to their functional characteristics

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Identification of protein receptor for Clostridium botulinum type B neurotoxin in rat brain synaptosomes.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Identification and Characterization of Botulinum Neurotoxin A Substrate Binding Pockets and Their Re-Engineering for Human SNAP-23.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Effect of botulinum toxin concentration on reduction in sweating: a randomized, double-blind study

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Botulinum neurotoxin serotype D is poorly effective in humans: an in vivo electrophysiological study.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

ClpL is required for folding of CtsR in Streptococcus mutans.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Activation of TRPV1 mediates calcitonin gene-related peptide release, which excites trigeminal sensory neurons and is attenuated by a retargeted botulinum toxin with anti-nociceptive potential

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

Synaptotagmins I and II act as nerve cell receptors for botulinum neurotoxin G.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

The high-affinity binding of Clostridium botulinum type B neurotoxin to synaptotagmin II associated with gangliosides GT1b/GD1a

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495808

How do tetanus and botulinum toxins bind to neuronal membranes?

19 August 2018

1 reference

https://api.crossref.org/works/10.1038/S41467-017-00064-Y

Neutralizing antibodies and secondary therapy failure after treatment with botulinum toxin type A: much ado about nothing?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/S41467-017-00064-Y

7 January 2021

Comparison of botulinum toxin serotypes A and B for the treatment of cervical dystonia

1 reference

https://api.crossref.org/works/10.1038/S41467-017-00064-Y

7 January 2021

Botulinum toxin type B vs. type A in toxin-naïve patients with cervical dystonia: Randomized, double-blind, noninferiority trial

1 reference

https://api.crossref.org/works/10.1038/S41467-017-00064-Y

7 January 2021

Longer-acting and highly potent chimaeric inhibitors of excessive exocytosis created with domains from botulinum neurotoxin A and B

1 reference

https://api.crossref.org/works/10.1038/S41467-017-00064-Y

7 January 2021

10.1038/S41467-017-00064-Y

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28674381 AND SRC:MED&resulttype=core&format=json

3 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28674381 AND SRC:MED&resulttype=core&format=json

3 June 2020

PubMed publication ID

28674381

1 reference