Divining the serpin inhibition mechanism: a suicide substrate 'springe'? (Q40964677)

25 September 2017

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title

Divining the serpin inhibition mechanism: a suicide substrate 'springe'? (English)

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25 September 2017

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Engh RA

1

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25 September 2017

Huber R

series ordinal

2

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25 September 2017

Bode W

series ordinal

3

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25 September 2017

Schulze AJ

series ordinal

4

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25 September 2017

publication date

1 December 1995

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25 September 2017

published in

Trends in Biotechnology

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25 September 2017

volume

13

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25 September 2017

issue

12

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25 September 2017

page(s)

503-510

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Structural aspects of serpin inhibition

25 September 2017

cites work

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What do dysfunctional serpins tell us about molecular mobility and disease?

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Natural protein proteinase inhibitors and their interaction with proteinases

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Effect of single amino acid replacements on the thermodynamics of the reactive site peptide bond hydrolysis in ovomucoid third domain

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Refined X-ray crystal structures of the reactive site modified ovomucoid inhibitor third domains from silver pheasant (OMSVP3*) and from Japanese quail (OMJPQ3*)

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7 January 2021

Human alpha 1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function

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Crystal structure of plakalbumin, a proteolytically nicked form of ovalbumin. Its relationship to the structure of cleaved alpha-1-proteinase inhibitor

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Crystal structure of ovalbumin as a model for the reactive centre of serpins

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Structural basis of latency in plasminogen activator inhibitor-1

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Conformational Studies on Plasminogen Activator Inhibitor (PAI-1) in Active, Latent, Substrate, and Cleaved Forms

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Mobile reactive centre of serpins and the control of thrombosis

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Mutations which impede loop/sheet polymerization enhance the secretion of human alpha 1-antitrypsin deficiency variants

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7 January 2021

The intact and cleaved human antithrombin III complex as a model for serpin–proteinase interactions

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Biological implications of a 3 A structure of dimeric antithrombin

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Crystal structure of an uncleaved serpin reveals the conformation of an inhibitory reactive loop

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7 January 2021

Structural transition of alpha 1-antitrypsin by a peptide sequentially similar to beta-strand s4A.

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7 January 2021

Evidence for the extent of insertion of the active site loop of intact alpha 1 proteinase inhibitor in beta-sheet A

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7 January 2021

Inhibitory activity and conformational transition of alpha1-proteinase inhibitor variants

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Alpha 1-proteinase inhibitor variant T345R. Influence of P14 residue on substrate and inhibitory pathways

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Modulation of protein C inhibitor activity

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Regulation of thrombin activity by antithrombin and heparin

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Determination of the vitronectin binding site on plasminogen activator inhibitor 1 (PAI‐1)

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7 January 2021

Inhibition of acrosin by serpins. A suicide substrate mechanism

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7 January 2021

Immunologic evidence for insertion of the reactive-bond loop of antithrombin into the A .beta.-sheet of the inhibitor during trapping of target proteinases

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7 January 2021

A fluorescent probe study of plasminogen activator inhibitor-1. Evidence for reactive center loop insertion and its role in the inhibitory mechanism

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7 January 2021

Sodium dodecyl sulfate-stable complexes between serpins and active or inactive proteinases contain the region COOH-terminal to the reactive site loop

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7 January 2021

Interaction of human α-1-antitrypsin with porcine trypsin

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7 January 2021

Trypsin complexed with α1‐proteinase inhibitor has an increased structural flexibility

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7 January 2021

Structure of an acyl-enzyme intermediate during catalysis: (guanidinobenzoyl)trypsin

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7 January 2021

Molecular evolution of plasminogen activator inhibitor-1 functional stability

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7 January 2021

Serpin-resistant mutants of human tissue-type plasminogen activator

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7 January 2021

Development of a novel recombinant serpin with potential antithrombotic properties

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Kinetics of the Interaction of alpha-Chymotrypsin with Trypsin Kallikrein Inhibitor (Kunitz) in Which the Reactive-Site Peptide Bond Lys-15-Ala-16 is Split

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7 January 2021

Structural basis for serpin inhibitor activity

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7 January 2021

10.1016/S0167-7799(00)89013-7

Identifiers

DOI

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25 September 2017

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