Homeodomain protein IDX-1: a master regulator of pancreas development and insulin gene expression (Q40894548)

24 September 2017

title

Homeodomain protein IDX-1: a master regulator of pancreas development and insulin gene expression (English)

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24 September 2017

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3

Habener JF

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24 September 2017

Stoffers DA

1

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24 September 2017

Thomas MK

series ordinal

2

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24 September 2017

language of work or name

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1 May 1997

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Trends in Endocrinology and Metabolism

24 September 2017

published in

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24 September 2017

volume

8

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24 September 2017

issue

4

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24 September 2017

page(s)

145-151

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Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons.

24 September 2017

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Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locus

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The insulin gene contains multiple transcriptional elements that respond to glucose

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Transcriptional activation by tetracyclines in mammalian cells

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A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2.

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Mutations at the PAX6 locus are found in heterogeneous anterior segment malformations including Peters' anomaly

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Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program

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Isolation, characterization, and chromosomal mapping of the human insulin promoter factor 1 (IPF-1) gene

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Insulin-promoter-factor 1 is required for pancreas development in mice

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Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion

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Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells

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Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex

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Glucose modulates the binding activity of the beta-cell transcription factor IUF1 in a phosphorylation-dependent manner

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7 January 2021

Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells

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Beta cell mass and growth after syngeneic islet cell transplantation in normal and streptozocin diabetic C57BL/6 mice

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Transplanted beta cell response to increased metabolic demand. Changes in beta cell replication and mass

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Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression

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Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1.

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The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain

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Multiple functions for Pax6 in mouse eye and nasal development.

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extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1.

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7 January 2021

Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities

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7 January 2021

The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site.

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7 January 2021

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7 January 2021

The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression

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7 January 2021

Pancreatic islet expression of the homeobox factor STF-1 relies on an E-box motif that binds USF.

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7 January 2021

Regulation of insulin gene transcription

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7 January 2021

Localization of Human Homeodomain Transcription Factor Insulin Promoter Factor I (IPF1) to Chromosome Band 13q12.1

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7 January 2021

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

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7 January 2021

Pancreatic beta-cell growth and diabetes mellitus

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7 January 2021

Cell lineage analysis of pancreatic islet development: glucagon and insulin cells arise from catecholaminergic precursors present in the pancreatic duct

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7 January 2021

Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor

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7 January 2021

Evidence for a new family of evolutionarily conserved homeobox genes

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7 January 2021

Early Pancreas Organogenesis: Morphogenesis, Tissue Interactions, and Mass Effects

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7 January 2021

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

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7 January 2021

Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)

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7 January 2021

Ontogenetic appearance of immunoreactive endocrine cells in rat pancreatic islets

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7 January 2021

10.1016/S1043-2760(97)00008-8

Identifiers

DOI

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24 September 2017

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