BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. (Q40886681)

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English	BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.	scientific article

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1 February 2020

BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins (English)

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1 February 2020

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William J Placzek

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1 February 2020

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1 February 2020

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Jun Wei

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1 February 2020

John L Stebbins

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1 February 2020

Shinichi Kitada

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1 February 2020

Michele F Rega

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1 February 2020

Bainan Wu

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1 February 2020

Jason Cellitti

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1 February 2020

Dayong Zhai

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1 February 2020

Li Yang

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1 February 2020

Russell Dahl

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1 February 2020

Paul B Fisher

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1 February 2020

John C Reed

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1 February 2020

Maurizio Pellecchia

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1 May 2010

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1 February 2020

Journal of Medicinal Chemistry

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1 February 2020

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1 February 2020

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1 February 2020

4166-4176

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1 February 2020

Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880850

24 September 2017

Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880850

24 September 2017

Synthesis and evaluation of Apogossypol atropisomers as potential Bcl-xL antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880850

24 September 2017

Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2880850

24 September 2017

Targeting BCL-2 family proteins to overcome drug resistance in non-small cell lung cancer

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24 September 2017

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

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24 September 2017

Structure-based discovery of a new class of Bcl-xL antagonists.

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24 September 2017

A small molecule pan-Bcl-2 family inhibitor, GX15-070, induces apoptosis and enhances cisplatin-induced apoptosis in non-small cell lung cancer cells

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24 September 2017

Structural insights into the degradation of Mcl-1 induced by BH3 domains

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24 September 2017

Bortezomib, but not cisplatin, induces mitochondria-dependent apoptosis accompanied by up-regulation of noxa in the non-small cell lung cancer cell line NCI-H460.

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24 September 2017

Downregulation of Bfl-1 protein expression sensitizes malignant B cells to apoptosis

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24 September 2017

Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL

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24 September 2017

Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins

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24 September 2017

Upregulation of two BH3-only proteins, Bmf and Bim, during TGF beta-induced apoptosis

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24 September 2017

Dual cancer-specific targeting strategy cures primary and distant breast carcinomas in nude mice

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24 September 2017

Killing cancer cells by flipping the Bcl-2/Bax switch.

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24 September 2017

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

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24 September 2017

Targeting gene expression selectively in cancer cells by using the progression-elevated gene-3 promoter

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24 September 2017

Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L).

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24 September 2017

Bcl-2 and Bcl-x(L) differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24.

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24 September 2017

Apoptosis-based therapies

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24 September 2017

Apoptosis: a link between cancer genetics and chemotherapy

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24 September 2017

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

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24 September 2017

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

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24 September 2017

Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460.

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24 September 2017

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

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24 September 2017

Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells

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24 September 2017

Dysregulation of apoptosis in cancer

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24 September 2017

BCL-2 family members and the mitochondria in apoptosis

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24 September 2017

The Bcl-2 protein family: arbiters of cell survival

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24 September 2017

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24 September 2017

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

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24 September 2017

Differential effects of Bcl-2 on T and B cells in transgenic mice

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25 September 2017

Synthesis and Anti-HIV Activity of 1,1'-Dideoxygossypol and Related Compounds

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25 September 2017

Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins

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17 June 2018

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17 June 2018

Bcl-2 family proteins: strategies for overcoming chemoresistance in cancer

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17 June 2018

Different forms of cell death induced by putative BCL2 inhibitors.

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Direct and selective arylation of tertiary silanes with rhodium catalyst

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19 August 2018

Chemosensitization of myeloma plasma cells by an antisense-mediated downregulation of Bcl-2 protein

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19 August 2018

Bcl-2 family proteins

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19 August 2018

Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(-)-gossypol] against diffuse large cell lymphoma

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12 December 2020

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Texture mapping: a new tool for molecular graphics

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Cell Death in Development

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12 December 2020

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Quantitative determination of apogossypol, a pro-apoptotic analog of gossypol, in mouse plasma using LC/MS/MS

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https://pubmed.ncbi.nlm.nih.gov/20443627

12 December 2020

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Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells

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10.1021/JM1001265

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1 February 2020

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1 February 2020

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1 February 2020

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