C-X-C motif chemokine ligand 12 (Q408598)

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mammalian protein found in Homo sapiens

• pre-B cell growth-stimulating factor
• IRH
• chemokine (C-X-C motif) ligand 12
• CXCL12
• intercrine reduced in hepatomas
• stromal cell-derived factor 1
• hIRH
• C-X-C motif chemokine 12
• PBSF
• Chemokine CXCL12
• CXCL12 protein, human

edit

Language	Label	Description	Also known as
English	C-X-C motif chemokine ligand 12	mammalian protein found in Homo sapiens	pre-B cell growth-stimulating factor IRH chemokine (C-X-C motif) ligand 12 CXCL12 intercrine reduced in hepatomas stromal cell-derived factor 1 hIRH C-X-C motif chemokine 12 PBSF Chemokine CXCL12 CXCL12 protein, human

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P48061

image

Protein CXCL12 PDB 1a15.png
731 × 694; 213 KB

0 references

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P48061

encoded by

CXCL12

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P48061

molecular function

chemokine receptor binding

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Ubiquitination of CXCR7 controls receptor trafficking

GOA

curator

UniProt

UniProt protein ID

P48061

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IMP

cytokine activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P48061

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

chemokine activity

determination method or standard

IDA

TAS

IEA

4 references

retrieved

31 October 2017

stated in

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

GOA

curator

UniProt

UniProt protein ID

P48061

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48061&geneProductId=UniProtKB:P48061

determination method or standard

TAS

retrieved

31 October 2017

stated in

Inhibition of CXCR4-dependent HIV-1 infection by extracellular HIV-1 Tat

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48061&geneProductId=UniProtKB:P48061

determination method or standard

TAS

retrieved

31 October 2017

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48061&geneProductId=UniProtKB:P48061

determination method or standard

IEA

retrieved

31 October 2017

stated in

CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow

GOA

curator

UniProt

UniProt protein ID

P48061

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48061&geneProductId=UniProtKB:P48061

determination method or standard

IDA

CXCR chemokine receptor binding

determination method or standard

IDA

1 reference

retrieved

31 October 2017

stated in

The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48061&geneProductId=UniProtKB:P48061

determination method or standard

IDA

chemoattractant activity

determination method or standard

IBA

1 reference

retrieved

31 October 2017

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48061&geneProductId=UniProtKB:P48061

determination method or standard

IBA

growth factor activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P48061

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

signaling receptor binding

determination method or standard

TAS

2 references

retrieved

8 April 2019

stated in

Roles of CD4 and coreceptors in binding, endocytosis, and proteolysis of gp120 envelope glycoproteins derived from human immunodeficiency virus type 1

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

TAS

retrieved

8 April 2019

stated in

Inhibition of tyrosine kinase activation blocks the down-regulation of CXC chemokine receptor 4 by HIV-1 gp120 in CD4 T cells

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

TAS

integrin binding

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Stromal cell-derived factor-1 (CXCL12) activates integrins by direct binding to an allosteric ligand-binding site (site 2) of integrins without CXCR4.

GOA

curator

UniProt

UniProt protein ID

P48061

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IDA

protein binding

determination method or standard

IPI

1 reference

retrieved

8 April 2019

stated in

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IPI

chemokine activity

determination method or standard

IBA

IDA

IEA

IMP

TAS

6 references

retrieved

8 April 2019

stated in

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

GOA

curator

UniProt

UniProt protein ID

P48061

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

TAS

retrieved

8 April 2019

stated in

Inhibition of CXCR4-dependent HIV-1 infection by extracellular HIV-1 Tat

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

TAS

retrieved

8 April 2019

stated in

WNK1 kinase balances T cell adhesion versus migration in vivo

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IMP

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

retrieved

8 April 2019

stated in

CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow

GOA

curator

UniProt

UniProt protein ID

P48061

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IBA

CXCR chemokine receptor binding

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IBA

cell component

plasma membrane

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

extracellular region

determination method or standard

IEA

TAS

3 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P48061

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

extracellular exosome

determination method or standard

IDA

2 references

retrieved

31 October 2017

stated in

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

GOA

curator

UniProt

UniProt protein ID

P48061

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48061&geneProductId=UniProtKB:P48061

determination method or standard

IDA

retrieved

31 October 2017

stated in

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

GOA

curator

UniProt

UniProt protein ID

P48061

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48061&geneProductId=UniProtKB:P48061

determination method or standard

IDA

external side of plasma membrane

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IBA

extracellular space

determination method or standard

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P48061

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

cytoplasm

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

nucleus

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

extracellular exosome

determination method or standard

HDA

1 reference

retrieved

8 April 2019

stated in

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

GOA

curator

UniProt

UniProt protein ID

P48061

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

HDA

collagen-containing extracellular matrix

determination method or standard

HDA

1 reference

retrieved

8 April 2019

stated in

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

HDA

biological process

negative regulation of leukocyte tethering or rolling

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow

GOA

curator

UniProt

UniProt protein ID

P48061

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IDA

G protein-coupled receptor signaling pathway

determination method or standard

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

TAS

retrieved

8 April 2019

stated in

The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

TAS

regulation of calcium ion transport

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

response to hypoxia

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

positive regulation of endothelial cell proliferation

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

positive regulation of cell migration

determination method or standard

IEA

1 reference

retrieved

31 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48061&geneProductId=UniProtKB:P48061

determination method or standard

IEA

chemokine-mediated signaling pathway

determination method or standard

IDA

1 reference

retrieved

31 October 2017

stated in

The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48061&geneProductId=UniProtKB:P48061

determination method or standard

IDA

adult locomotory behavior

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

response to mechanical stimulus

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

response to peptide hormone

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

positive regulation of monocyte chemotaxis

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Monocyte migration and LFA-1-mediated attachment to brain microvascular endothelia is regulated by SDF-1 alpha through Lyn kinase

GOA

curator

UniProt

UniProt protein ID

P48061

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IDA

cellular calcium ion homeostasis

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Inhibition of CXCR4-dependent HIV-1 infection by extracellular HIV-1 Tat

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

TAS

response to virus

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Inhibition of CXCR4-dependent HIV-1 infection by extracellular HIV-1 Tat

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

TAS

neuron migration

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

response to heat

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IDA

positive regulation of axon extension involved in axon guidance

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

blood circulation

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Inhibition of CXCR4-dependent HIV-1 infection by extracellular HIV-1 Tat

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

TAS

telencephalon cell migration

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

chemotaxis

determination method or standard

IEA

TAS

4 references

retrieved

8 April 2019

stated in

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

GOA

curator

UniProt

UniProt protein ID

P48061

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

TAS

retrieved

8 April 2019

stated in

A highly selective CC chemokine receptor (CCR)8 antagonist encoded by the poxvirus molluscum contagiosum

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P48061

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

regulation of actin polymerization or depolymerization

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

TAS

positive regulation of calcium ion import

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Human galectin-3 is a novel chemoattractant for monocytes and macrophages

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

TAS

brain development

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

cell adhesion

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Specific activation of leukocyte beta2 integrins lymphocyte function-associated antigen-1 and Mac-1 by chemokines mediated by distinct pathways via the alpha subunit cytoplasmic domains

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

TAS

positive regulation of dopamine secretion

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

animal organ regeneration

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

positive regulation of neuron differentiation

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

immune response

determination method or standard

TAS

IEA

2 references

retrieved

8 April 2019

stated in

Active movement of T cells away from a chemokine

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

positive regulation of cell population proliferation

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

cell chemotaxis

determination method or standard

IDA

1 reference

retrieved

31 October 2017

stated in

CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow

GOA

curator

UniProt

UniProt protein ID

P48061

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48061&geneProductId=UniProtKB:P48061

determination method or standard

IDA

negative regulation of leukocyte apoptotic process

determination method or standard

IDA

1 reference

retrieved

31 October 2017

stated in

Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48061&geneProductId=UniProtKB:P48061

determination method or standard

IDA

response to radiation

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

positive regulation of T cell migration

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IDA

positive regulation of cell adhesion

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IDA

signal transduction

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1 alpha-induced lymphocyte polarization and chemotaxis

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

TAS

positive chemotaxis

determination method or standard

IEA

1 reference

retrieved

31 October 2017

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48061&geneProductId=UniProtKB:P48061

determination method or standard

IEA

induction of positive chemotaxis

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IBA

defense response

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

response to ultrasound

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

antimicrobial humoral immune response mediated by antimicrobial peptide

determination method or standard

IDA

1 reference

retrieved

31 October 2017

stated in

Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.

GOA

curator

UniProt

UniProt protein ID

P48061

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48061&geneProductId=UniProtKB:P48061

determination method or standard

IDA

T cell chemotaxis

determination method or standard

IDA

1 reference

retrieved

31 October 2017

stated in

Crystal structures of human alpha-defensins HNP4, HD5, and HD6

GOA

curator

UniProt

UniProt protein ID

P48061

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48061&geneProductId=UniProtKB:P48061

determination method or standard

IDA

detection of temperature stimulus involved in sensory perception of pain

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

detection of mechanical stimulus involved in sensory perception of pain

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

regulation of signaling receptor activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

axon guidance

determination method or standard

IBA

TAS

2 references

retrieved

31 October 2017

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48061&geneProductId=UniProtKB:P48061

determination method or standard

TAS

retrieved

31 October 2017

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48061&geneProductId=UniProtKB:P48061

determination method or standard

IBA

axon guidance

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

TAS

viral process

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P48061

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

positive regulation of cell migration

determination method or standard

IBA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IBA

integrin activation

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Stromal cell-derived factor-1 (CXCL12) activates integrins by direct binding to an allosteric ligand-binding site (site 2) of integrins without CXCR4.

GOA

curator

UniProt

UniProt protein ID

P48061

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IDA

chemokine (C-X-C motif) ligand 12 signaling pathway

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

WNK1 kinase balances T cell adhesion versus migration in vivo

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IMP

cell chemotaxis

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow

GOA

curator

UniProt

UniProt protein ID

P48061

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IBA

chemokine-mediated signaling pathway

determination method or standard

IBA

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IEA

retrieved

8 April 2019

stated in

The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IBA

cellular response to chemokine

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

WNK1 kinase balances T cell adhesion versus migration in vivo

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IMP

negative regulation of dendritic cell apoptotic process

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48061

determination method or standard

IDA

Gene Atlas image

PBB GE CXCL12 209687 at fs.png
732 × 530; 11 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P48061

1 reference

stated in

Identifiers.org

Identifiers

MeSH descriptor ID

C515255

subject named as

CXCL12 protein, human

0 references

RefSeq protein ID

NP_000600

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

6387

NP_001029058

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

6387

NP_001171605

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

6387

NP_001264919

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

6387

NP_954637

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

6387

UniProt protein ID

P48061

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P48061

Ensembl protein ID

ENSP00000339913

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000339913

ENSP00000363548

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000363548

ENSP00000363551

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000363551

ENSP00000379139

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000379139

ENSP00000379140

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000379140

ENSP00000379141

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000379141

Freebase ID

/m/03tkq_

1 reference

stated in

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

2776610909

0 references

OpenAlex ID

C2776610909

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1A15

1 reference

stated in

UniProt

UniProt protein ID

P48061

retrieved

9 August 2016

language of work or name

English

1QG7

1 reference

stated in

UniProt

UniProt protein ID

P48061

retrieved

9 August 2016

language of work or name

English

1SDF

1 reference

stated in

UniProt

UniProt protein ID

P48061

retrieved

9 August 2016

language of work or name

English

1VMC

1 reference

stated in

UniProt

UniProt protein ID

P48061

retrieved

9 August 2016

language of work or name

English

2J7Z

1 reference

stated in

UniProt

UniProt protein ID

P48061

retrieved

9 August 2016

language of work or name

English

2K01

1 reference

stated in

UniProt

UniProt protein ID

P48061

retrieved

9 August 2016

language of work or name

English

2K03

1 reference

stated in

UniProt

UniProt protein ID

P48061

retrieved

9 August 2016

language of work or name

English

2K04

1 reference

stated in

UniProt

UniProt protein ID

P48061

retrieved

9 August 2016

language of work or name

English

2K05

1 reference

stated in

UniProt

UniProt protein ID

P48061

retrieved

9 August 2016

language of work or name

English

2KEC

1 reference

stated in

UniProt

UniProt protein ID

P48061

retrieved

9 August 2016

language of work or name

English

2KED

1 reference

stated in

UniProt

UniProt protein ID

P48061

retrieved

9 August 2016

language of work or name

English

2KEE

1 reference

stated in

UniProt

UniProt protein ID

P48061

retrieved

9 August 2016

language of work or name

English

2KOL

1 reference

stated in

UniProt

UniProt protein ID

P48061

retrieved

9 August 2016

language of work or name

English

2NWG

1 reference

stated in

UniProt

UniProt protein ID

P48061

retrieved

9 August 2016

language of work or name

English

2SDF

1 reference

stated in

UniProt

UniProt protein ID

P48061

retrieved

9 August 2016

language of work or name

English

3GV3

1 reference

stated in

UniProt

UniProt protein ID

P48061

retrieved

9 August 2016

language of work or name

English

3HP3

1 reference

stated in

UniProt

UniProt protein ID

P48061

retrieved

9 August 2016

language of work or name

English

4LMQ

1 reference

stated in

UniProt

UniProt protein ID

P48061

retrieved

9 August 2016

language of work or name

English

4UAI

1 reference

stated in

UniProt

UniProt protein ID

P48061

retrieved

9 August 2016

language of work or name

English

2N55

1 reference

stated in

UniProt

UniProt protein ID

P48061

retrieved

9 August 2016

language of work or name

English

 

Sitelinks

Wikipedia(13 entries)

edit

• bswiki CXCL12
• cywiki CXCL12
• dewiki CXCL12
• enwiki Stromal cell-derived factor 1
• fawiki SDF1
• frwiki CXCL12
• jawiki CXCL12
• nlwiki SDF-1
• ruwiki SDF-1 (белок)
• shwiki CXCL12
• srwiki CXCL12
• ukwiki CXCL12
• zhwiki CXCL12

Wikibooks(0 entries)

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Wikinews(0 entries)

edit

Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

edit

Multilingual sites(0 entries)

edit

Retrieved from "https://www.wikidata.org/w/index.php?title=Q408598&oldid=2022900993"