Bombesin and substance P analogues differentially regulate G-protein coupling to the bombesin receptor. Direct evidence for biased agonism (Q40809869)

23 September 2017

title

Bombesin and substance P analogues differentially regulate G-protein coupling to the bombesin receptor. Direct evidence for biased agonism (English)

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23 September 2017

MacKinnon AC

1

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23 September 2017

Waters C

2

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23 September 2017

Jodrell D

3

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23 September 2017

Haslett C

4

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23 September 2017

Sethi T

5

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23 September 2017

language of work or name

English

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publication date

25 April 2001

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Journal of Biological Chemistry

23 September 2017

number of pages

9

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based on heuristic

inferred from page(s)

published in

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23 September 2017

volume

276

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23 September 2017

issue

30

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23 September 2017

page(s)

28083-28091

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Growth factor and peptide receptors in small cell lung cancer

23 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

Gq and G11 are concurrently activated by bombesin and vasopressin in Swiss 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

The bombesin receptor subtypes have distinct G protein specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

G alpha 12 and G alpha 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

Galpha12 and Galpha13 stimulate Rho-dependent tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130 Crk-associated substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

Differential involvement of Galpha12 and Galpha13 in receptor-mediated stress fiber formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

Galpha(13) stimulates Rho-dependent activation of the cyclooxygenase-2 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

[D-Arg1,D-Trp5,7,9,Leu11]Substance P coordinately and reversibly inhibits bombesin- and vasopressin-induced signal transduction pathways in Swiss 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

[Arg6,D-Trp7,9,NmePhe8]-substance P (6-11) activates JNK and induces apoptosis in small cell lung cancer cells via an oxidant-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

[D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P induces apoptosis in lung cancer cell lines in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

[Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6-11) (antagonist G) induces AP-1 transcription and sensitizes cells to chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

d-Arg1,d-Phe5,d-Trp7,9,Leu11Substance P Acts as a Biased Agonist toward Neuropeptide and Chemokine Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

Differential modulation of bombesin-stimulated phospholipase C beta and mitogen-activated protein kinase activity by [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

Agonist-receptor efficacy. II. Agonist trafficking of receptor signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

[D-Arg(1),D-Trp(5,7,9),Leu(11)]Substance P inhibits bombesin-induced mitogenic signal transduction mediated by both G(q) and G(12) in Swiss 3T3cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

Identification of Four Amino Acids in the Gastrin-releasing Peptide Receptor That Are Required for High Affinity Agonist Binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

An aspartate residue at the extracellular boundary of TMII and an arginine residue in TMVII of the gastrin-releasing peptide receptor interact to facilitate heterotrimeric G protein coupling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

Galpha12 stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

Activation of Jun Kinase/Stress-activated Protein Kinase by GTPase-deficient Mutants of Gα12 and Gα13

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

Role for G(12)/G(13) in agonist-induced vascular smooth muscle cell contraction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

Bombesin and neuromedin B stimulate the activation of p42(mapk) and p74(raf-1) via a protein kinase C-independent pathway in Rat-1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

Antitumor Activity of a Monoclonal Antibody Directed Against Gastrin-Releasing Peptide in Patients With Small Cell Lung Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. I. Activation of protein kinase C and inhibition of epidermal growth factor binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

Gi proteins use a novel beta gamma- and Ras-independent pathway to activate extracellular signal-regulated kinase and mobilize AP-1 transcription factors in Jurkat T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

Purification of Recombinant G Proteins from Sf9 Cells by Hexahistidine Tagging of Associated Subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

The use of stimulus-biased assay systems to detect agonist-specific receptor active states: implications for the trafficking of receptor stimulus by agonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

The deletion of 14 amino acids in the seventh transmembrane domain of a naturally occurring calcitonin receptor isoform alters ligand binding and selectively abolishes coupling to phospholipase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

T-cell mitogens cause early changes in cytoplasmic free Ca2 and membrane potential in lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M009772200

21 January 2018

Identifiers

DOI

10.1074/JBC.M009772200

1 reference

23 September 2017

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