Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation (Q40773928)

23 September 2017

title

Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation (English)

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23 September 2017

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H Zhou

1

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23 September 2017

S H Li

series ordinal

2

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23 September 2017

X J Li

series ordinal

3

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23 September 2017

language of work or name

English

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publication date

17 October 2001

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Journal of Biological Chemistry

23 September 2017

number of pages

8

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based on heuristic

inferred from page(s)

published in

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23 September 2017

volume

276

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23 September 2017

issue

51

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23 September 2017

page(s)

48417-48424

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Glutamine repeats and neurodegenerative diseases: molecular aspects

23 September 2017

cites work

1 reference

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Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity

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Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease

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Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

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Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

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21 January 2018

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Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone

21 January 2018

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The chaperone function of hsp70 is required for protection against stress-induced apoptosis

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Intranuclear huntingtin increases the expression of caspase-1 and induces apoptosis

21 January 2018

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Huntingtin's neuroprotective activity occurs via inhibition of procaspase-9 processing

21 January 2018

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An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

21 January 2018

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21 January 2018

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Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

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The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs

21 January 2018

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Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13

21 January 2018

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Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation

21 January 2018

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Interaction of the N-ethylmaleimide-sensitive factor with AMPA receptors.

21 January 2018

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Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.

21 January 2018

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Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M104140200

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