Target Density, Not Affinity or Avidity of Antigen Recognition, Determines Adoptive T Cell Therapy Outcomes in a Mouse Lymphoma Model. (Q40731929)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27036915 AND SRC:MED&resulttype=core&format=json

31 March 2020

title

Target Density, Not Affinity or Avidity of Antigen Recognition, Determines Adoptive T Cell Therapy Outcomes in a Mouse Lymphoma Model (English)

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31 March 2020

4

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31 March 2020

Jose A. Villadangos

5

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31 March 2020

Gabriela Segal

1

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31 March 2020

author name string

Sandro Prato

2

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31 March 2020

Dietmar Zehn

3

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31 March 2020

language of work or name

English

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publication date

1 April 2016

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31 March 2020

published in

Journal of Immunology

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31 March 2020

volume

196

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31 March 2020

issue

9

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page(s)

3935-3942

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Adoptive immunotherapy for cancer or viruses

31 March 2020

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T cell receptor antagonist peptides induce positive selection

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Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection.

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Characterization of two TCR transgenic mouse lines specific for herpes simplex virus.

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Tissue destruction caused by cytotoxic T lymphocytes induces deletional tolerance

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Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity

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T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity

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T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion?

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High Avidity Cytotoxic T Lymphocytes Can Be Selected into the Memory Pool but They Are Exquisitely Sensitive to Functional Impairment

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Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

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Human T cells expressing affinity-matured TCR display accelerated responses but fail to recognize low density of MHC-peptide antigen

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Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition

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Serial triggering of many T-cell receptors by a few peptide-MHC complexes

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Transnuclear TRP1-specific CD8 T cells with high or low affinity TCRs show equivalent antitumor activity

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T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy

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Supraoptimal peptide-major histocompatibility complex causes a decrease in bc1-2 levels and allows tumor necrosis factor alpha receptor II-mediated apoptosis of cytotoxic T lymphocytes

21 January 2018

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An abrupt and concordant initiation of apoptosis: antigen-dependent death of CD8 CTL.

21 January 2018

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Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses

21 January 2018

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Targeting antigen to diverse APCs inactivates memory CD8 T cells without eliciting tissue-destructive effector function

21 January 2018

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From TCR Engagement to T Cell Activation

21 January 2018

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21 January 2018

Identifiers

DOI

10.4049/JIMMUNOL.1502187

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27036915 AND SRC:MED&resulttype=core&format=json

31 March 2020

1 reference