Inhibition of human immunodeficiency virus type 1 reverse transcriptase, RNase H, and integrase activities by hydroxytropolones. (Q40666856)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16304149 AND SRC:MED&resulttype=core&format=json

9 January 2020

title

Inhibition of human immunodeficiency virus type 1 reverse transcriptase, RNase H, and integrase activities by hydroxytropolones (English)

1 reference

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9 January 2020

8

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9 January 2020

Catherine Isel

2

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9 January 2020

5

Anne-Marie Aubertin

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9 January 2020

author name string

Joël Didierjean

1

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9 January 2020

Flore Querré

3

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9 January 2020

Jean-François Mouscadet

4

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9 January 2020

Jean-Yves Valnot

6

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9 January 2020

Serge R Piettre

7

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9 January 2020

language of work or name

English

0 references

publication date

1 December 2005

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Antimicrobial Agents and Chemotherapy

9 January 2020

published in

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9 January 2020

volume

49

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9 January 2020

issue

12

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9 January 2020

page(s)

4884-4894

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Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones

9 January 2020

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22 September 2017

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Rational design and synthesis of novel dimeric diketoacid-containing inhibitors of HIV-1 integrase: implication for binding to two metal ions on the active site of integrase

22 September 2017

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Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors

22 September 2017

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Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes

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Unique progressive cleavage mechanism of HIV reverse transcriptase RNase H

22 September 2017

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Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding

22 September 2017

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22 September 2017

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Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design

22 September 2017

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Crystal structures of catalytic core domains of retroviral integrases and role of divalent cations in enzymatic activity.

22 September 2017

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22 September 2017

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HIV-1 reverse transcription: a brief overview focused on structure-function relationships among molecules involved in initiation of the reaction

22 September 2017

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Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution

22 September 2017

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Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

22 September 2017

1 reference

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Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases

22 September 2017

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Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium

22 September 2017

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Interaction of Retroviral Reverse Transcriptase with Template–Primer Duplexes during Replication

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Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity

22 September 2017

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Biochemical analysis of catalytically crucial aspartate mutants of human immunodeficiency virus type 1 reverse transcriptase.

22 September 2017

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Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases

22 September 2017

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Recombining the structures of HIV integrase, RuvC and RNase H.

22 September 2017

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Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase

22 September 2017

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22 September 2017

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Dimerization of human immunodeficiency virus (type 1) RNA: stimulation by cations and possible mechanism

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Inhibition of the ribonuclease H and DNA polymerase activities of HIV-1 reverse transcriptase by N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone

22 September 2017

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15 June 2018

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Bicyclic imidazo derivatives, a new class of highly selective inhibitors for the human immunodeficiency virus type 1.

15 June 2018

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The interaction of illimaquinone, a selective inhibitor of the RNase H activity, with the reverse transcriptases of human immunodeficiency and murine leukemia retroviruses

15 June 2018

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Point mutations in conserved amino acid residues within the C-terminal domain of HIV-1 reverse transcriptase specifically repress RNase H function

15 June 2018

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Mechanistic insights into the suppression of drug resistance by human immunodeficiency virus type 1 reverse transcriptase using alpha-boranophosphate nucleoside analogs

15 June 2018

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HCV NS5b RNA-dependent RNA polymerase inhibitors: from alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis

19 August 2018

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19 August 2018

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Metabolic complications associated with the use of highly active antiretroviral therapy in HIV-1-infected adults

19 August 2018

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Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques

19 August 2018

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19 August 2018

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19 August 2018

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19 August 2018

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19 August 2018

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Divalent cation modulation of the ribonuclease functions of human immunodeficiency virus reverse transcriptase

19 August 2018

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19 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16304149

12 December 2020

inferred from PubMed ID database lookup

Monoaryl- and Bisaryldihydroxytropolones as Potent Inhibitors of Inositol Monophosphatase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16304149

12 December 2020

inferred from PubMed ID database lookup

Transmission of antiretroviral-drug-resistant HIV-1 variants

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16304149

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1128/AAC.49.12.4884-4894.2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16304149 AND SRC:MED&resulttype=core&format=json

release_jri5sjsvsraixmoccne4dshhje

9 January 2020

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/jri5sjsvsraixmoccne4dshhje

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16304149 AND SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

16304149

1 reference