Construction of a cyclin D1-Cdk2 fusion protein to model the biological functions of cyclin D1-Cdk2 complexes (Q40517888)

21 September 2017

title

Construction of a cyclin D1-Cdk2 fusion protein to model the biological functions of cyclin D1-Cdk2 complexes (English)

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21 September 2017

3

Robert West

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author name string

Anna Chytil

1

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21 September 2017

Mary Waltner-Law

2

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21 September 2017

David Friedman

4

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21 September 2017

Mary Aakre

5

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21 September 2017

Dana Barker

6

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21 September 2017

Brian Law

7

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21 September 2017

language of work or name

English

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publication date

7 September 2004

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Journal of Biological Chemistry

21 September 2017

published in

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21 September 2017

volume

279

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21 September 2017

issue

46

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21 September 2017

page(s)

47688-47698

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Cyclin D1 provides a link between development and oncogenesis in the retina and breast

21 September 2017

cites work

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Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

21 January 2018

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ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells

21 January 2018

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Cyclin-dependent kinase inhibitor p27(Kip1) is required for mouse mammary gland morphogenesis and function

21 January 2018

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Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

21 January 2018

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Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence

21 January 2018

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Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1).

21 January 2018

1 reference

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Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.

21 January 2018

1 reference

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Cyclin D1/cdk2 kinase is present in a G1 phase-specific protein complex Yi1 that binds to the mouse thymidine kinase gene promoter

21 January 2018

1 reference

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Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes

21 January 2018

1 reference

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Lack of relationship between CDK activity and G1 cyclin expression in breast cancer cells

21 January 2018

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Cyclin-dependent kinase-2 (Cdk2) forms an inactive complex with cyclin D1 since Cdk2 associated with cyclin D1 is not phosphorylated by Cdk7-cyclin-H.

21 January 2018

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Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells

21 January 2018

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A simplified system for generating recombinant adenoviruses

21 January 2018

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Efficient in vitro transduction of epithelial cells and keratinocytes with improved adenoviral gene transfer for the application in skin tissue engineering

21 January 2018

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Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

21 January 2018

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Function of a human cyclin gene as an oncogene

21 January 2018

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Distinct roles for cyclin-dependent kinases in cell cycle control

21 January 2018

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Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen

21 January 2018

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Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway

21 January 2018

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Farnesyltransferase inhibitor induces rapid growth arrest and blocks p70s6k activation by multiple stimuli

21 January 2018

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Transforming growth factor-beta induces Cdk2 relocalization to the cytoplasm coincident with dephosphorylation of retinoblastoma tumor suppressor protein

21 January 2018

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New functional activities for the p21 family of CDK inhibitors

21 January 2018

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The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

21 January 2018

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Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway

21 January 2018

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Conditional transformation of rat embryo fibroblast cells by a cyclin D1-cdk4 fusion gene.

21 January 2018

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21 January 2018

The Hallmarks of Cancer

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Isolation and characterization of a spontaneously transformed malignant mouse mammary epithelial cell line in culture

21 January 2018

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Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)

21 January 2018

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p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F.

21 January 2018

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p21 Disrupts the interaction between cdk2 and the E2F-p130 complex

21 January 2018

1 reference

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Ectopic Expression of Cyclin D1 but Not Cyclin E Induces Anchorage-Independent Cell Cycle Progression

21 January 2018

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Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M405938200

Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation

21 January 2018

1 reference

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Loss of growth responsiveness to epidermal growth factor and enhanced production of alpha-transforming growth factors inras-transformed mouse mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M405938200

21 January 2018

Identifiers

DOI

10.1074/JBC.M405938200

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21 September 2017

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