Overexpression of enzymatically active human cytosolic and mitochondrial thioredoxin reductase in HEK-293 cells. Effect on cell growth and differentiation. (Q40506655)

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English	Overexpression of enzymatically active human cytosolic and mitochondrial thioredoxin reductase in HEK-293 cells. Effect on cell growth and differentiation.	scientific article

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Overexpression of enzymatically active human cytosolic and mitochondrial thioredoxin reductase in HEK-293 cells. Effect on cell growth and differentiation (English)

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Antonio Miranda-Vizuete

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Anastasios E Damdimopoulos

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Christina Nystöm

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Tomas Nordman

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Jerker M Olsson

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Lennart Eriksson

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Mikael Björnstedt

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Giannis Spyrou

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7 October 2004

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Journal of Biological Chemistry

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3 January 2020

Evidence for intriguingly complex transcription of human thioredoxin reductase 1.

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Human mitochondrial thioredoxin reductase cDNA cloning, expression and genomic organization

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

The mitochondrial thioredoxin system

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Redox regulation of cellular activation

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Monitoring antisense oligodeoxynucleotide activity in hematopoietic cells

1 reference

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21 January 2018

The role of the redox protein thioredoxin in cell growth and cancer

1 reference

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21 January 2018

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Thioredoxin reductase

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Reactive oxygen species, antioxidants, and the mammalian thioredoxin system

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Selenocysteine insertion sequence element characterization and selenoprotein expression

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Protein factors mediating selenoprotein synthesis

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Evolutionarily different RNA motifs and RNA-protein complexes to achieve selenoprotein synthesis

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

RNA binding proteins and selenocysteine

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Decoding apparatus for eukaryotic selenocysteine insertion

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Characterization of mSelB, a novel mammalian elongation factor for selenoprotein translation

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Coupled tRNA(Sec)-dependent assembly of the selenocysteine decoding apparatus

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Selenite is a substrate for calf thymus thioredoxin reductase and thioredoxin and elicits a large non-stoichiometric oxidation of NADPH in the presence of oxygen

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase. Implications for the antitumor effects of selenium

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Rapid induction of cell death by selenium-compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Cloning and characterization of a novel oxidoreductase KDRF from a human bone marrow-derived stromal cell line KM-102.

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Regulation of human thioredoxin reductase expression and activity by 3'-untranslated region selenocysteine insertion sequence and mRNA instability elements

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Cloning, sequencing and functional expression of a novel human thioredoxin reductase

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

SECIS-SBP2 interactions dictate selenocysteine incorporation efficiency and selenoprotein hierarchy

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Intervening sequences increase efficiency of RNA 3' processing and accumulation of cytoplasmic RNA

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

The novel mechanism of initiation of picornavirus RNA translation

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Conventional cell culture media do not adequately supply cells with antioxidants and thus facilitate peroxide-induced genotoxicity

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Mismatch Binding Protein-Based Mutation Detection Systems

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Glutathione peroxidase activity in selenium-deficient rat liver

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Human mitochondrial thioredoxin reductase reduces cytochrome c and confers resistance to complex III inhibition.

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Tissue-specific functions of individual glutathione peroxidases

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Mechanism and regulation of selenoprotein synthesis

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

3'UTRs of glutathione peroxidases differentially affect selenium-dependent mRNA stability and selenocysteine incorporation efficiency

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Thioredoxin reductase mediates cell death effects of the combination of beta interferon and retinoic acid

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Mutational analysis of human thioredoxin reductase 1. Effects on p53-mediated gene expression and interferon and retinoic acid-induced cell death

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Proteome analysis of hepatocellular carcinoma cell strains, MHCC97-H and MHCC97-L, with different metastasis potentials

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Upregulation of 9 genes, including that for thioredoxin, during epithelial differentiation of mesothelioma cells

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

The selenoprotein thioredoxin reductase is expressed in peripheral blood monocytes and THP1 human myeloid leukemia cells--regulation by 1,25-dihydroxyvitamin D3 and selenite

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Mitochondrial thioredoxin system: effects of TrxR2 overexpression on redox balance, cell growth, and apoptosis

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Contrasting patterns of regulation of the antioxidant selenoproteins, thioredoxin reductase, and glutathione peroxidase, in cancer cells

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Requirement for generation of H2O2 for platelet-derived growth factor signal transduction

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Involvements of mitochondrial thioredoxin reductase (TrxR2) in cell proliferation

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Overexpression of thioredoxin reductase 1 regulates NF‐κB activation

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB.

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Thioredoxin reductase regulates AP-1 activity as well as thioredoxin nuclear localization via active cysteines in response to ionizing radiation

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Physical and functional sensitivity of zinc finger transcription factors to redox change

1 reference

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21 January 2018

An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling

1 reference

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21 January 2018

Mitochondrial localization of estrogen receptor beta

1 reference

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21 January 2018

Heterogeneity within animal thioredoxin reductases. Evidence for alternative first exon splicing

1 reference

https://api.crossref.org/works/10.1074/JBC.M408494200

21 January 2018

Redox regulation of fos and jun DNA-binding activity in vitro

1 reference

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21 January 2018

Recognition of UGA as a selenocysteine codon in Type I deiodinase requires sequences in the 3′ untranslated region

1 reference

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21 January 2018

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10.1074/JBC.M408494200

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15471857 AND SRC:MED&resulttype=core&format=json

3 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15471857 AND SRC:MED&resulttype=core&format=json

3 January 2020

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