Farnesyltransferase inhibitor SCH-66336 downregulates secretion of matrix proteinases and inhibits carcinoma cell migration. (Q40478997)

20 September 2017

title

Farnesyltransferase inhibitor SCH-66336 downregulates secretion of matrix proteinases and inhibits carcinoma cell migration. (English)

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20 September 2017

Richard R Desrosiers

1

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20 September 2017

Marie-Hélène Cusson

series ordinal

2

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20 September 2017

Sandra Turcotte

series ordinal

3

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20 September 2017

Richard Béliveau

series ordinal

4

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20 September 2017

language of work or name

English

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publication date

1 May 2005

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International Journal of Cancer

20 September 2017

published in

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20 September 2017

volume

114

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20 September 2017

issue

5

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20 September 2017

page(s)

702-712

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Farnesyltransferase inhibitors: potential role in the treatment of cancer

20 September 2017

cites work

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The farnesyl transferase inhibitor SCH 66336 induces a G(2) --> M or G(1) pause in sensitive human tumor cell lines

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Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia

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A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis

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21 January 2018

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c-Ras is required for the activation of the matrix metalloproteinases by concanavalin A in 3Y1 cells

21 January 2018

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Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences.

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Differential expression of matrix metalloproteinases in activated c-rasHa-transfected immortalized human keratinocytes

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Progelatinase A mRNA expression in cell lines derived from tumors in patients with metastatic renal cell carcinoma correlates inversely with survival

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Regulation of carcinoma cell invasion by protein C inhibitor whose expression is decreased in renal cell carcinoma

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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Phase I and pharmacological study of the oral farnesyltransferase inhibitor SCH 66336 given once daily to patients with advanced solid tumours

21 January 2018

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Inhibitors of farnesyl protein transferase and MEK1,2 induce apoptosis in fibroblasts transformed with farnesylated but not geranylgeranylated H-Ras

21 January 2018

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Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336.

21 January 2018

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Farnesyl transferase inhibitor SCH66336 is cytostatic, pro-apoptotic and enhances chemosensitivity to cisplatin in melanoma cells

21 January 2018

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Inhibition of glucose- and calcium-induced insulin secretion from betaTC3 cells by novel inhibitors of protein isoprenylation

21 January 2018

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Rho proteins: linking signaling with membrane trafficking

21 January 2018

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Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activity

21 January 2018

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Tumor cell invasion of model 3-dimensional matrices: demonstration of migratory pathways, collagen disruption, and intercellular cooperation.

21 January 2018

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The microtubule-stabilizing agents epothilones A and B and their desoxy-derivatives induce mitotic arrest and apoptosis in human prostate cancer cells.

21 January 2018

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Penta-O-galloyl-beta-D-glucose inhibits the invasion of mouse melanoma by suppressing metalloproteinase-9 through down-regulation of activator protein-1.

21 January 2018

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A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers

21 January 2018

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Characterization of the promoter of the gene encoding human tissue inhibitor of metalloproteinases-2 (TIMP-2).

21 January 2018

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Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 1.

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Regulation of u-PA gene expression in human prostate cancer

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Signal transduction-mediated regulation of urokinase gene expression in human prostate cancer

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.20807

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20 September 2017

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