Dimerization through the catalytic domain is essential for MEKK2 activation. (Q40461283)

20 September 2017

title

Dimerization through the catalytic domain is essential for MEKK2 activation. (English)

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20 September 2017

Jinke Cheng

1

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20 September 2017

Ling Yu

2

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20 September 2017

Dongyu Zhang

3

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20 September 2017

Qiaojia Huang

4

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20 September 2017

David Spencer

5

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20 September 2017

Bing Su

6

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20 September 2017

language of work or name

English

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publication date

4 February 2005

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Journal of Biological Chemistry

20 September 2017

published in

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20 September 2017

volume

280

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20 September 2017

issue

14

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20 September 2017

page(s)

13477-13482

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A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

20 September 2017

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1 reference

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Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation

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Mekk3 is essential for early embryonic cardiovascular development

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MEKK2 is required for T-cell receptor signals in JNK activation and interleukin-2 gene expression

21 January 2018

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Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo

21 January 2018

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21 January 2018

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Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation

21 January 2018

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Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells

21 January 2018

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MEKK2 regulates the coordinate activation of ERK5 and JNK in response to FGF-2 in fibroblasts

21 January 2018

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MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src

21 January 2018

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Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis

21 January 2018

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JNK is involved in signal integration during costimulation of T lymphocytes.

21 January 2018

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21 January 2018

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21 January 2018

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Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation

21 January 2018

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Dimerization of cell surface receptors in signal transduction

21 January 2018

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21 January 2018

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TGF-beta signal transduction

21 January 2018

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Controlling Signal Transduction with Synthetic Ligands

21 January 2018

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Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity

21 January 2018

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Membrane localization, oligomerization, and phosphorylation are required for optimal raf activation

21 January 2018

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Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins

21 January 2018

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PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway

21 January 2018

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Molecular recognition in dimerization between PB1 domains

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M414258200

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20 September 2017

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