Sodium-calcium exchange inhibitors: therapeutic potential in cardiovascular diseases (Q40409849)

20 September 2017

title

Sodium-calcium exchange inhibitors: therapeutic potential in cardiovascular diseases (English)

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20 September 2017

main subject

cardiovascular disease

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Takahiro Iwamoto

1

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20 September 2017

publication date

1 July 2005

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20 September 2017

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20 September 2017

volume

1

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20 September 2017

issue

4

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20 September 2017

page(s)

519-529

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Cardiac excitation-contraction coupling

20 September 2017

cites work

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Calcium signalling: dynamics, homeostasis and remodelling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Alterations of calcium-regulatory proteins in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Mechanisms of Ca2 overload in reperfused ischemic myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Cardiac Na( )-Ca(2 ) exchange: molecular and pharmacological aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

The sodium/calcium exchanger family?SLC8

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

A new topological model of the cardiac sarcolemmal Na -Ca2 exchanger

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Unique topology of the internal repeats in the cardiac Na /Ca2 exchanger

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Helix packing of functionally important regions of the cardiac Na( )-Ca(2 ) exchanger

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Mutational analysis of the alpha-1 repeat of the cardiac Na( )-Ca2 exchanger

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Regulation of cardiac Na( )-Ca2 exchanger by the endogenous XIP region

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Regulation of the cardiac Na( )-Ca2 exchanger by Ca2 . Mutational analysis of the Ca(2 )-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Phosphorylation-dependent regulation of cardiac Na /Ca2 exchanger via protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Regulation of cardiac Na ,Ca2 exchange and KATP potassium channels by PIP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Allosteric regulation of Na/Ca exchange current by cytosolic Ca in intact cardiac myocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Calcium-dependent regulation of calcium efflux by the cardiac sodium/calcium exchanger

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

A novel antagonist, No. 7943, of the Na /Ca2 exchange current in guinea-pig cardiac ventricular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

The novel Na( )/Ca(2 ) exchange inhibitor KB-R7943 also blocks native and expressed neuronal nicotinic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Effect of SEA0400, a novel inhibitor of sodium-calcium exchanger, on myocardial ionic currents

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Ca2 -dependent modulation of intracellular Mg2 concentration with amiloride and KB-R7943 in pig carotid artery

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Knockout mice for pharmacological screening: testing the specificity of Na -Ca2 exchange inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

The exchanger inhibitory peptide region-dependent inhibition of Na /Ca2 exchange by SN-6 [2-[4-(4-nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic acid ethyl ester], a novel benzyloxyphenyl derivative

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Synthesis and structure-activity relationships of 6-{4-[(3-fluorobenzyl)oxy]phenoxy}nicotinamide derivatives as a novel class of NCX inhibitors: a QSAR study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Molecular determinants of Na /Ca2 exchange (NCX1) inhibition by SEA0400.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Salt-sensitive hypertension is triggered by Ca2 entry via Na /Ca2 exchanger type-1 in vascular smooth muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Inhibitory profile of SEA0400 [2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline] assessed on the cardiac Na -Ca2 exchanger, NCX1.1.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Direction-independent block of bi-directional Na /Ca2 exchange current by KB-R7943 in guinea-pig cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Effects of SEA0400 on mutant NCX1.1 Na -Ca2 exchangers with altered ionic regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Effects of a selective inhibitor of Na /Ca2 exchange, KB-R7943, on reoxygenation-induced injuries in guinea pig papillary muscles

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Effect of inhibition of Na( )/Ca(2 ) exchanger at the time of myocardial reperfusion on hypercontracture and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Protective effects of SEA0400, a novel and selective inhibitor of the Na /Ca2 exchanger, on myocardial ischemia-reperfusion injuries

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Inhibition by KB-r7943 of the reverse mode of the Na /Ca2 exchanger reduces Ca2 overload in ischemic-reperfused rat hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Hydroxyl radical-induced acute diastolic dysfunction is due to calcium overload via reverse-mode Na( )-Ca(2 ) exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Very low dose of the Na( )/Ca(2 ) exchange inhibitor, KB-R7943, protects ischemic reperfused aged Fischer 344 rat hearts: considerable strain difference in the sensitivity to KB-R7943.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Cardioprotective effect of SEA0400, a selective inhibitor of the Na( )/Ca(2 ) exchanger, on myocardial ischemia-reperfusion injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Effects of SEA0400, a novel inhibitor of the Na /Ca2 exchanger, on myocardial stunning in anesthetized dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

A Na /Ca2 exchanger inhibitor, KB-R7943, caused negative inotropic responses and negative followed by positive chronotropic responses in isolated, blood-perfused dog heart preparations

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Targeted disruption of Na /Ca2 exchanger gene leads to cardiomyocyte apoptosis and defects in heartbeat

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Role of Na -Ca2 exchanger in myocardial ischemia/reperfusion injury: evaluation using a heterozygous Na -Ca2 exchanger knockout mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Overexpression of the cardiac Na /Ca2 exchanger increases susceptibility to ischemia/reperfusion injury in male, but not female, transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Altered Na/Ca exchange activity in cardiac hypertrophy and heart failure: a new target for therapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Relevance of Na -Ca2 exchange in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Partial inhibition of sodium/calcium exchange restores cellular calcium handling in canine heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Impaired contractile performance of cultured rabbit ventricular myocytes after adenoviral gene transfer of Na( )-Ca(2 ) exchanger

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Mice overexpressing the cardiac sodium-calcium exchanger: defects in excitation-contraction coupling.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Calcium Signaling in Transgenic Mice Overexpressing Cardiac Na -Ca2 Exchanger

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Effect of Na /Ca2 exchange inhibitor, KB-R7943 on ouabain-induced arrhythmias in guinea-pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Effects of SEA0400, a Na /Ca2 exchange inhibitor, on ventricular arrhythmias in the in vivo dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Ischemia/reperfusion-induced arrhythmias in anaesthetized rats: a role of Na and Ca2 influx

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

KB-R7943, a Na /Ca2 exchange inhibitor, does not suppress ischemia/reperfusion arrhythmias nor digitalis arrhythmias in dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Trends in the prevalence of hypertension, antihypertensive therapy, and left ventricular hypertrophy from 1950 to 1989.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Elevated systolic blood pressure as a cardiovascular risk factor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Subtle renal injury is likely a common mechanism for salt-sensitive essential hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Hypertension with a grain of salt

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Identification and characterization of a ouabain-like compound from human plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Endogenous cardiac glycosides, a new class of steroid hormones

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

The alpha2-isoform of Na-K-ATPase mediates ouabain-induced hypertension in mice and increased vascular contractility in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

Functional adult myocardium in the absence of Na -Ca2 exchange: cardiac-specific knockout of NCX1

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14796678.1.4.519

21 January 2018

Identifiers

DOI

10.2217/14796678.1.4.519

1 reference

20 September 2017

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