Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation (Q40403963)

20 September 2017

title

Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation (English)

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20 September 2017

main subject

protein ubiquitination

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4

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20 September 2017

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Fei Hong

1

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20 September 2017

Konjeti R Sekhar

series ordinal

2

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20 September 2017

Michael L Freeman

series ordinal

3

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20 September 2017

language of work or name

English

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publication date

28 June 2005

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Journal of Biological Chemistry

20 September 2017

published in

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20 September 2017

volume

280

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20 September 2017

issue

36

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20 September 2017

page(s)

31768-31775

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Chemoprotection against cancer by induction of phase 2 enzymes

20 September 2017

cites work

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Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis

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Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention

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Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

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Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

21 January 2018

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Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins

21 January 2018

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Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

21 January 2018

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An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

21 January 2018

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Up-regulation of the human gamma-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf-2 to an electrophile responsive element

21 January 2018

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Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2.

21 January 2018

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Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene

21 January 2018

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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

21 January 2018

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

21 January 2018

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Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

21 January 2018

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Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

21 January 2018

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Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

21 January 2018

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Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

21 January 2018

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The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

21 January 2018

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BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

21 January 2018

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

21 January 2018

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Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

21 January 2018

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A proteomics approach to understanding protein ubiquitination

21 January 2018

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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

21 January 2018

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COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases

21 January 2018

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The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?

21 January 2018

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Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism

21 January 2018

1 reference

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The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M503346200

21 January 2018

Identifiers

DOI

10.1074/JBC.M503346200

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20 September 2017

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