Glutamate receptors at atomic resolution (Q40340618)

19 September 2017

title

Glutamate receptors at atomic resolution (English)

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19 September 2017

Mark L Mayer

1

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19 September 2017

language of work or name

English

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publication date

1 March 2006

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19 September 2017

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19 September 2017

volume

440

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19 September 2017

issue

7083

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19 September 2017

page(s)

456-462

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Excitatory Amino Acid Transmitters

19 September 2017

cites work

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The physiology of excitatory amino acids in the vertebrate central nervous system

21 January 2018

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Roles and rules of kainate receptors in synaptic transmission.

21 January 2018

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An outbreak of toxic encephalopathy caused by eating mussels contaminated with domoic acid

21 January 2018

1 reference

Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

21 January 2018

1 reference

RNA editing in brain controls a determinant of ion flow in glutamate-gated channels

21 January 2018

1 reference

Selective RNA editing and subunit assembly of native glutamate receptors

21 January 2018

1 reference

Functional assembly of AMPA and kainate receptors is mediated by several discrete protein-protein interactions

21 January 2018

1 reference

Two regions in the N-terminal domain of ionotropic glutamate receptor 3 form the subunit oligomerization interfaces that control subtype-specific receptor assembly

21 January 2018

1 reference

Molecular organization of a zinc binding n-terminal modulatory domain in a NMDA receptor subunit

21 January 2018

1 reference

Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor channels lacking the N-terminal domain

21 January 2018

1 reference

Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins

21 January 2018

1 reference

Probing the ligand binding domain of the GluR2 receptor by proteolysis and deletion mutagenesis defines domain boundaries and yields a crystallizable construct

21 January 2018

1 reference

21 January 2018

1 reference

A common architecture for K channels and ionotropic glutamate receptors?

21 January 2018

1 reference

Functional characterization of a potassium-selective prokaryotic glutamate receptor

21 January 2018

1 reference

The outer pore of the glutamate receptor channel has 2-fold rotational symmetry

21 January 2018

1 reference

Postsynaptic protein phosphorylation and LTP.

21 January 2018

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Intracellular domains of NR2 alter calcium-dependent inactivation of N-methyl-D-aspartate receptors.

21 January 2018

1 reference

Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry

21 January 2018

1 reference

A venus flytrap mechanism for activation and desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors

21 January 2018

1 reference

Atomic structure and specificity of bacterial periplasmic receptors for active transport and chemotaxis: variation of common themes

21 January 2018

1 reference

Mechanisms for ligand binding to GluR0 ion channels: crystal structures of the glutamate and serine complexes and a closed apo state

21 January 2018

1 reference

Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists

21 January 2018

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Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core

21 January 2018

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Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivity

21 January 2018

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Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core

21 January 2018

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Structural basis for partial agonist action at ionotropic glutamate receptors

21 January 2018

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Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core

21 January 2018

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Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists

21 January 2018

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Activation of ion channels in the frog end-plate by high concentrations of acetylcholine

21 January 2018

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The tetrameric structure of a glutamate receptor channel

21 January 2018

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Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes

21 January 2018

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Mechanism of partial agonist action at the NR1 subunit of NMDA receptors

21 January 2018

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Mechanism of partial agonism at NMDA receptors for a conformationally restricted glutamate analog.

21 January 2018

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Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling

21 January 2018

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Subunit arrangement and function in NMDA receptors

21 January 2018

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Protein flexibility using constraints from molecular dynamics simulations.

21 January 2018

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The open pore conformation of potassium channels

21 January 2018

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Activation of NR1/NR2B NMDA receptors.

21 January 2018

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Maximum likelihood fitting of single channel NMDA activity with a mechanism composed of independent dimers of subunits

21 January 2018

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Mechanism of glutamate receptor desensitization

21 January 2018

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Regulation of AMPA receptor gating by ligand binding core dimers

21 January 2018

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Mechanism of positive allosteric modulators acting on AMPA receptors

21 January 2018

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Block of AMPA receptor desensitization by a point mutation outside the ligand-binding domain.

21 January 2018

1 reference

A binding site tyrosine shapes desensitization kinetics and agonist potency at GluR2. A mutagenic, kinetic, and crystallographic study

21 January 2018

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Channel kinetics determine the time course of NMDA receptor-mediated synaptic currents

21 January 2018

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Heteromeric NMDA receptors: molecular and functional distinction of subtypes

21 January 2018

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Structure of the NMDA receptor channel M2 segment inferred from the accessibility of substituted cysteines

21 January 2018

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NMDAR channel segments forming the extracellular vestibule inferred from the accessibility of substituted cysteines

21 January 2018

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State-dependent changes in the electrostatic potential in the pore of a GluR channel

21 January 2018

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Structure and gating of the glutamate receptor ion channel

21 January 2018

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Molecular mechanism of AMPA receptor noncompetitive antagonism

21 January 2018

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Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond

21 January 2018

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Neurodegeneration in Lurcher mice caused by mutation in δ2 glutamate receptor gene

21 January 2018

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Mutation of a glutamate receptor motif reveals its role in gating and delta2 receptor channel properties.

21 January 2018

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Effects of the lurcher mutation on GluR1 desensitization and activation kinetics.

21 January 2018

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Stargazin modulates AMPA receptor gating and trafficking by distinct domains

21 January 2018

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Stargazin modulates native AMPA receptor functional properties by two distinct mechanisms.

21 January 2018

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Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors

21 January 2018

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Relative abundance of subunit mRNAs determines gating and Ca2 permeability of AMPA receptors in principal neurons and interneurons in rat CNS

21 January 2018

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High-Affinity Zinc Inhibition of NMDA NR1–NR2A Receptors

21 January 2018

1 reference

7 January 2021

Mapping the binding site of the neuroprotectant ifenprodil on NMDA receptors.

1 reference

7 January 2021

A regulatory domain (R1-R2) in the amino terminus of the N-methyl-D-aspartate receptor: effects of spermine, protons, and ifenprodil, and structural similarity to bacterial leucine/isoleucine/valine binding protein

1 reference

7 January 2021

Molecular dissection of the agonist binding site of an AMPA receptor.

1 reference

7 January 2021

Regulation of GluR1 by the A-kinase anchoring protein 79 (AKAP79) signaling complex shares properties with long-term depression.

1 reference

7 January 2021

Binding site flexibility: molecular simulation of partial and full agonists within a glutamate receptor.

1 reference

7 January 2021

AMPA receptor flip/flop mutants affecting deactivation, desensitization, and modulation by cyclothiazide, aniracetam, and thiocyanate.

1 reference

7 January 2021

Ligand affinities at recombinant N-methyl-D-aspartate receptors depend on subunit composition

1 reference

7 January 2021

DRPEER: a motif in the extracellular vestibule conferring high Ca2 flux rates in NMDA receptor channels.

1 reference

7 January 2021

Studies of NMDA receptor function and stoichiometry with truncated and tandem subunits.

1 reference

7 January 2021

Identifiers

DOI

10.1038/NATURE04709

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Dimensions Publication ID

19 September 2017

1024931886

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