Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD. (Q40318581)

19 September 2017

title

Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD. (English)

1 reference

19 September 2017

0 references

18

1 reference

19 September 2017

14

Marju Orho-Melander

1 reference

19 September 2017

Taru Tukiainen

9

0 references

Quentin M Anstee

Quentin M Anstee

16

0 references

Panu K Luukkonen

Panu K Luukkonen

1

0 references

Tuulia Hyötyläinen

Tuulia Hyötyläinen

5

0 references

Hannele Yki-Järvinen

20

Hannele Yki-Järvinen

1 reference

19 September 2017

19

Leif Groop

1 reference

19 September 2017

13

Johanna Arola

1 reference

19 September 2017

17

Vesa M Olkkonen

1 reference

19 September 2017

8

Marja Leivonen

1 reference

19 September 2017

7

Anne Juuti

1 reference

Pachakkil Antharaparambath Nidhina Haridas

19 September 2017

3

P A Nidhina Haridas

1 reference

19 September 2017

10

Linda Ahonen

1 reference

19 September 2017

You Zhou

2

1 reference

19 September 2017

Om P Dwivedi

4

1 reference

19 September 2017

Ashfaq Ali

6

1 reference

19 September 2017

Emma Scott

11

1 reference

19 September 2017

Jeremy M Palmer

12

1 reference

19 September 2017

Petter Vikman

15

1 reference

19 September 2017

publication date

21 February 2017

1 reference

19 September 2017

published in

Journal of Hepatology

1 reference

19 September 2017

volume

67

1 reference

19 September 2017

issue

1

1 reference

19 September 2017

page(s)

128-136

1 reference

Polyunsaturated fatty acid metabolites as novel lipidomic biomarkers for noninvasive diagnosis of nonalcoholic steatohepatitis

19 September 2017

cites work

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

An unexpected requirement for phosphatidylethanolamine N-methyltransferase in the secretion of very low density lipoproteins

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Transmembrane-6 superfamily member 2 (TM6SF2) E167K variant increases susceptibility to hepatic steatosis in obese children

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Apolipoprotein B secretory regulation by degradation

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2

2 references

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

27 August 2024

https://opencitations.net/index/api/v1/citations/10.1016/J.JHEP.2014.10.010

Transcriptional Regulation of the Mitochondrial Citrate and Carnitine/Acylcarnitine Transporters: Two Genes Involved in Fatty Acid Biosynthesis and β-oxidation

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Physiological Consequences of Compartmentalized Acyl-CoA Metabolism

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Cytotoxicity and apoptosis produced by arachidonic acid in Hep G2 cells overexpressing human cytochrome P4502E1.

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

The plasma lipidomic signature of nonalcoholic steatohepatitis

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Polyunsaturated fatty acid regulation of genes of lipid metabolism

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Group IVA phospholipase A2 participates in the progression of hepatic fibrosis.

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

People with fatty liver are more likely to have the PEMT rs7946 SNP, yet populations with the mutant allele do not have fatty liver

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD)

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Reduced time points to calculate the composite index

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Phosphatidylcholine biosynthesis and lipoprotein metabolism

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

More powerful procedures for multiple significance testing

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

TM6SF2 Glu167Lys polymorphism is associated with low levels of LDL-cholesterol and increased liver injury in obese children

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Dissociating fatty liver and diabetes

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Diverse impacts of the rs58542926 E167K variant in TM6SF2 on viral and metabolic liver disease phenotypes

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

The phosphatidylethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese population

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Ethanol and arachidonic acid increase alpha 2(I) collagen expression in rat hepatic stellate cells overexpressing cytochrome P450 2E1. Role of H2O2 and cyclooxygenase-2.

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

TM6SF2 may drive postprandial lipoprotein cholesterol toxicity away from the vessel walls to the liver in NAFLD

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Inactivation of Tm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

PNPLA3 variant I148M is associated with altered hepatic lipid composition in humans

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Dietary phospholipids, hepatic lipid metabolism and cardiovascular disease

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease.

2 references

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

27 August 2024

https://opencitations.net/index/api/v1/citations/10.1016/J.JHEP.2016.01.002

Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Activity of hepatic fatty acid oxidation enzymes in rats fed alpha-linolenic acid

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Regulation of intestinal NPC1L1 expression by dietary fish oil and docosahexaenoic acid

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Control of free arachidonic acid levels by phospholipases A2 and lysophospholipid acyltransferases.

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

The triple threat to nascent apolipoprotein B. Evidence for multiple, distinct degradative pathways

1 reference

27 August 2024

https://opencitations.net/index/api/v1/references/10.1016/J.JHEP.2017.02.014

Identifiers

DOI

10.1016/J.JHEP.2017.02.014

1 reference

19 September 2017

1 reference