Apoptosis induced by intracellular ceramide accumulation in MDA-MB-435 breast carcinoma cells is dependent on the generation of reactive oxygen species (Q40290366)

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scientific article published on 19 April 2006

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English	Apoptosis induced by intracellular ceramide accumulation in MDA-MB-435 breast carcinoma cells is dependent on the generation of reactive oxygen species	scientific article published on 19 April 2006

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Apoptosis induced by intracellular ceramide accumulation in MDA-MB-435 breast carcinoma cells is dependent on the generation of reactive oxygen species (English)

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

0 references

reactive oxygen species

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based on heuristic

inferred from title

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based on heuristic

inferred from title

breast carcinoma

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based on heuristic

inferred from title

author name string

S Y Velda Chan

1

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Europe PubMed Central

PubMed publication ID

19 September 2017

Ashley L Hilchie

2

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Europe PubMed Central

PubMed publication ID

19 September 2017

Michael G Brown

3

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Europe PubMed Central

PubMed publication ID

19 September 2017

Robert Anderson

4

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Europe PubMed Central

PubMed publication ID

19 September 2017

David W Hoskin

5

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Europe PubMed Central

PubMed publication ID

19 September 2017

publication date

19 April 2006

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Europe PubMed Central

PubMed publication ID

19 September 2017

Experimental and Molecular Pathology

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Europe PubMed Central

PubMed publication ID

19 September 2017

82

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Europe PubMed Central

PubMed publication ID

19 September 2017

1

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Europe PubMed Central

PubMed publication ID

19 September 2017

1-11

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Europe PubMed Central

PubMed publication ID

19 September 2017

Purification and Characterization of 1-O-Acylceramide Synthase, a Novel Phospholipase A2 with Transacylase Activity

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Sphingomyelin hydrolysis during apoptosis

1 reference

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Fenretinide cytotoxicity for Ewing's sarcoma and primitive neuroectodermal tumor cell lines is decreased by hypoxia and synergistically enhanced by ceramide modulators

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(1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase

1 reference

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Glucosylceramide synthase and apoptosis

1 reference

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Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation

1 reference

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Tamoxifen retards glycosphingolipid metabolism in human cancer cells

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Taxol-induced ceramide generation and apoptosis in human breast cancer cells

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Ceramide inhibits L-type calcium channel currents in GH3 cells

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Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

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Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

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Mitochondrial ceramide increases in UV-irradiated HeLa cells and is mainly derived from hydrolysis of sphingomyelin

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Ceramide does not act as a general second messenger for ultraviolet-induced apoptosis

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Mammalian caspases: structure, activation, substrates, and functions during apoptosis

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Mechanisms involved in exogenous C2- and C6-ceramide-induced cancer cell toxicity

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Ceramide Induces CytochromecRelease from Isolated Mitochondria

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Glutathione depletion-induced chromosomal DNA fragmentation associated with apoptosis and necrosis.

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Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

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Sphingolipid metabolism enzymes as targets for anticancer therapy

1 reference

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Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells

1 reference

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Ceramide-mediated apoptosis in lung epithelial cells is regulated by glutathione

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Detection of mitochondria-derived reactive oxygen species production by the chemilumigenic probes lucigenin and luminol

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Apoptosis. DNA destroyers

1 reference

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Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells

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7 January 2021

Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells

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Mechanisms of tamoxifen-induced apoptosis

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The JAM test. A simple assay for DNA fragmentation and cell death

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Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells

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Ceramide-induced killing of normal and malignant human lymphocytes is by a non-apoptotic mechanism

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Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology

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Ceramide-induced apoptosis in fas-resistant Hodgkin's disease cell lines is caspase independent.

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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Paclitaxel-induced apoptosis in Jurkat, a leukemic T cell line, is enhanced by ceramide

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Enhancement of radiosensitivity by combined ceramide and dimethylsphingosine treatment in lung cancer cells

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ROS stress in cancer cells and therapeutic implications

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Stress-induced apoptosis and the sphingomyelin pathway

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The role of de novo ceramide synthesis in the mechanism of action of the tricyclic xanthate D609.

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Simultaneous flow cytometric method to measure phagocytosis and oxidative products by neutrophils

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Ceramide in apoptosis: an overview and current perspectives

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Prevalence of necrosis in C2-ceramide-induced cytotoxicity in NB16 neuroblastoma cells

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Ceramide synthesis and metabolism as a target for cancer therapy.

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Changes in mitochondrial membrane potential during oxidative stress-induced apoptosis in PC12 cells

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Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling

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Intracellular delivery of ceramide lipids via liposomes enhances apoptosis in vitro

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Mitochondrial ceramide and the induction of apoptosis

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Sphingosine-1-phosphate in cell growth and cell death

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Liposomal delivery enhances short-chain ceramide-induced apoptosis of breast cancer cells

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Systemic delivery of liposomal short-chain ceramide limits solid tumor growth in murine models of breast adenocarcinoma.

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A flow-cytometric method for the separation and quantitation of normal and apoptotic thymocytes

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Interleukin-2-induced survival of natural killer (NK) cells involving phosphatidylinositol-3 kinase-dependent reduction of ceramide through acid sphingomyelinase, sphingomyelin synthase, and glucosylceramide synthase

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Increasing intracellular ceramide: an approach that enhances the cytotoxic response in prostate cancer cells

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Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

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Ceramide induces caspase-dependent and -independent apoptosis in A-431 cells

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Ceramidase and ceramide synthesis in human kidney and cerebellum. Description of a new alkaline ceramidase

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Positive feedback control of neutral sphingomyelinase activity by ceramide

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based on heuristic

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Identifiers

10.1016/J.YEXMP.2006.03.001

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

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