Targeted molecular therapy of the PI3K pathway: therapeutic significance of PI3K subunit targeting in colorectal carcinoma (Q40268278)

19 September 2017

title

Targeted molecular therapy of the PI3K pathway: therapeutic significance of PI3K subunit targeting in colorectal carcinoma (English)

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19 September 2017

5

B Mark Evers

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19 September 2017

Piotr G Rychahou

1

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19 September 2017

Lindsey N Jackson

series ordinal

2

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19 September 2017

Scott R Silva

series ordinal

3

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19 September 2017

Srinivasan Rajaraman

series ordinal

4

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19 September 2017

language of work or name

English

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publication date

1 June 2006

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19 September 2017

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19 September 2017

volume

243

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19 September 2017

issue

6

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19 September 2017

page(s)

833-42; discussion 843-4

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Exploring the tumour environment: cancer-associated fibroblasts as targets in cancer therapy

19 September 2017

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29 August 2018

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29 August 2018

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29 August 2018

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29 August 2018

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29 August 2018

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29 August 2018

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29 August 2018

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29 August 2018

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Down-regulation of PIK3CG, a catalytic subunit of phosphatidylinositol 3-OH kinase, by CpG hypermethylation in human colorectal carcinoma.

29 August 2018

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29 August 2018

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PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway

29 August 2018

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29 August 2018

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29 August 2018

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29 August 2018

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Augmentation of sodium butyrate-induced apoptosis by phosphatidylinositol 3'-kinase inhibition in the KM20 human colon cancer cell line.

29 August 2018

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AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis

29 August 2018

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The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors.

29 August 2018

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Wortmannin inhibits pkb/akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice.

29 August 2018

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Oncogenic kinase signalling

29 August 2018

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29 August 2018

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In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice

29 August 2018

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29 August 2018

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Signaling by distinct classes of phosphoinositide 3-kinases

29 August 2018

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High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA.

29 August 2018

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

29 August 2018

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29 August 2018

Phosphoinositide kinases

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Pten is essential for embryonic development and tumour suppression

29 August 2018

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Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors.

29 August 2018

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Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

29 August 2018

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Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

29 August 2018

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

29 August 2018

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Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase

29 August 2018

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29 August 2018

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A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

29 August 2018

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

29 August 2018

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Inhibition of neurotensin-induced pancreatic carcinoma growth by a nonpeptide neurotensin receptor antagonist, SR48692

29 August 2018

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12 December 2020

Phospatidylinositol 3-kinase expression in human breast cancer

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12 December 2020

Mutation of the PIK3CA gene in ovarian and breast cancer

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12 December 2020

Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis

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12 December 2020

RNA interference targeting Fas protects mice from fulminant hepatitis

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12 December 2020

[TNM classification of malignant tumors: the new 1987 edition]

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12 December 2020

Acute pathological effects on rats of orally administered wortmannin-containing preparations and purified wortmannin from Fusarium oxysporum

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12 December 2020

10.1097/01.SLA.0000220040.66012.A9

Identifiers

DOI

1 reference

19 September 2017

0 references

1 reference