Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates. (Q40251135)

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3 January 2020

title

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates (English)

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Stephen T Safrany

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3 January 2020

Dario Alessi

8

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3 January 2020

Daan van Aalten

9

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David Komander

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3 January 2020

author name string

Alison Fairservice

2

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3 January 2020

Maria Deak

3

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3 January 2020

Gursant S Kular

4

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C Peter Downes

6

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3 January 2020

language of work or name

English

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publication date

30 September 2004

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3 January 2020

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volume

23

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issue

20

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3 January 2020

page(s)

3918-3928

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The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1.

3 January 2020

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PDK1, the master regulator of AGC kinase signal transduction

22 September 2017

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The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation

22 September 2017

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Inositol lipids: to PHix or not to PHix?

22 September 2017

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The pleckstrin homology domain of phosphoinositide-specific phospholipase Cdelta4 is not a critical determinant of the membrane localization of the enzyme

22 September 2017

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Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway

22 September 2017

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Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome

22 September 2017

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PTEN M-CBR3, a versatile and selective regulator of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Evidence for Ins(1,3,4,5,6)P5 as a proliferative signal

22 September 2017

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Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change

22 September 2017

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In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation

22 September 2017

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Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma

22 September 2017

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High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

22 September 2017

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The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate

22 September 2017

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Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity

22 September 2017

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22 September 2017

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Synthesis and function of 3-phosphorylated inositol lipids

21 January 2018

1 reference

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Back in the water: the return of the inositol phosphates

22 September 2017

1 reference

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Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

22 September 2017

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Cellular signaling: pivoting around PDK-1.

22 September 2017

1 reference

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Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains

22 September 2017

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Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains

22 September 2017

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Signal-dependent membrane targeting by pleckstrin homology (PH) domains

22 September 2017

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Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation

22 September 2017

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Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase

22 September 2017

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22 September 2017

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The PI3K-PDK1 connection: more than just a road to PKB

21 January 2018

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Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate

22 September 2017

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Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

22 September 2017

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Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains

22 September 2017

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Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

22 September 2017

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Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

22 September 2017

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Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

22 September 2017

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

22 September 2017

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Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin

22 September 2017

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

22 September 2017

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Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts

22 September 2017

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Characterization of the Pleckstrin Homology Domain of Btk as an Inositol Polyphosphate and Phosphoinositide Binding Domain

17 June 2018

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Thrombin receptors modulate insulin-stimulated phosphatidylinositol 3,4,5-trisphosphate accumulation in 1321N1 astrocytoma cells

17 June 2018

1 reference

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Purification, crystallization and preliminary X-ray diffraction of a proteolytic fragment of PDK1 containing the pleckstrin homology domain.

17 June 2018

1 reference

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Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions

20 August 2018

1 reference

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The multiplying roles of inositol lipids and phosphates in cell control processes

20 August 2018

1 reference

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High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

20 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038/SJ.EMBOJ.7600379

Protein Lipid Overlay Assay

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038/SJ.EMBOJ.7600379

21 January 2018

Identifiers

DOI

10.1038/SJ.EMBOJ.7600379

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15457207 AND SRC:MED&resulttype=core&format=json

3 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15457207 AND SRC:MED&resulttype=core&format=json

3 January 2020

PubMed publication ID

15457207

1 reference