Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor (Q40237882)

18 September 2017

title

Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor (English)

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18 September 2017

Barbara Tanos

1

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18 September 2017

Ann Marie Pendergast

series ordinal

2

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18 September 2017

language of work or name

English

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publication date

29 August 2006

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Journal of Biological Chemistry

18 September 2017

published in

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18 September 2017

volume

281

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18 September 2017

issue

43

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18 September 2017

page(s)

32714-32723

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Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases

18 September 2017

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Growth factor receptor binding protein 2-mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sufficient to support receptor endocytosis

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Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization

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Activated Cdc42 Sequesters c-Cbl and Prevents EGF Receptor Degradation

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c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

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Activation of Abl tyrosine kinases promotes invasion of aggressive breast cancer cells

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Comparative tyrosine-kinase profiles in colorectal cancers: enhanced arg expression in carcinoma as compared with adenoma and normal mucosa.

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Renal medullary carcinoma and ABL gene amplification

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Abl tyrosine kinases are required for infection by Shigella flexneri

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21 January 2018

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The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling

21 January 2018

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Autophosphorylation sites on the epidermal growth factor receptor.

21 January 2018

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Enhanced tumorigenic behavior of glioblastoma cells expressing a truncated epidermal growth factor receptor is mediated through the Ras-Shc-Grb2 pathway

21 January 2018

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21 January 2018

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Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins

21 January 2018

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Negative receptor signalling

21 January 2018

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Epidermal growth factor receptor activation under oxidative stress fails to promote c-Cbl mediated down-regulation

21 January 2018

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HPV16 E5 protein disrupts the c-Cbl-EGFR interaction and EGFR ubiquitination in human foreskin keratinocytes

21 January 2018

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Expression of constitutively activated EGFRvIII in non-small cell lung cancer

21 January 2018

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Regulation of signal transduction by endocytosis

21 January 2018

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Escape from Cbl-mediated downregulation: a recurrent theme for oncogenic deregulation of receptor tyrosine kinases

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M603126200

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18 September 2017

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