Metabolism of carcinogenic amino derivatives in various species and DNA alkylation by their metabolites (Q40214805)

18 September 2017

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title

Metabolism of carcinogenic amino derivatives in various species and DNA alkylation by their metabolites (English)

1 reference

18 September 2017

Schut HA

1

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18 September 2017

Castonguay A

series ordinal

2

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18 September 2017

language of work or name

English

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publication date

1 January 1984

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18 September 2017

published in

Drug Metabolism Reviews

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18 September 2017

volume

15

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18 September 2017

issue

4

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18 September 2017

page(s)

753-839

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Searches for ultimate chemical carcinogens and their reactions with cellular macromolecules.

18 September 2017

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Identification of glutathione conjugates formed from N-hydroxy-2-acetylaminofluorene in the rat.

21 January 2018

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On the mechanism of action of carcinogenic aromatic amines. I. Binding of 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene to rat-liver nucleic acids in vivo.

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The binding of N-hydroxy-2-acetylaminofluorene to DNA and repair of the adducts in primary rat hepatocyte cultures

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Binding of N-hydroxy acetylaminofluorene to eu- and heterochromatin fractions of rat liver in vivo

21 January 2018

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Quantitative and qualitative aspects of the binding of N-hydroxy-2-acetylaminofluorene to hepatic chromatin fractions

21 January 2018

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In vivo binding of N-2-acetylaminofluorene and its N-hydroxy derivative to the DNA of fractionated rat liver chromatin

21 January 2018

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Modification of ribonucleic acid by chemical carcinogens IV. Circular dichroism and proton magnetic resonance studies of oligonucleotides modified with N-2-acetylaminofluorene

21 January 2018

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Physical studies on deoxyribonucleic acid after covalent binding of a carcinogen

21 January 2018

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Mutagenicity of 7-iodo and 7-fluoro derivatives of N-hydroxy- and N-acetoxy-n-2-acetylaminoflourene in the Salmonella typbimurium assay

21 January 2018

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Sensitivity of the conformation of deoxyguanosine to binding at the C-8 position by N-acetylated and unacetylated 2-aminofluorene

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Induction of the base displacement or Z conformation in DNA by N-2-acetylaminofluorene modification

21 January 2018

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Conformation of oligonucleotides and nucleic acids modified with 2-aminofluorene or 2-acetylaminofluorene

21 January 2018

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Mechanisms of action of carcinogenic aromatic amines: An investigation using mutagenesis in bacteria

21 January 2018

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Detection of carcinogen-DNA adducts by radiommunoassay

21 January 2018

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Formation and persistence of DNA adducts from the carcinogen N-hydroxy-2-acetylaminofluorene in rat mammary gland in vivo.

21 January 2018

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Prevention of the hepatotoxic action of N-hydroxy-2-acetylaminofluorene in the rat by inhibition of N-O-sulfation by pentachlorophenol.

21 January 2018

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Differences in removal of acetylaminofluorene and pyrimidine dimers from the DNA of cultured mammalian cells

21 January 2018

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The biochemistry of aromatic amines. The metabolism of 2-naphthylamine and 2-naphthylhydroxylamine derivatives

21 January 2018

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The N-hydroxylation and ring-hydroxylation of 4-aminobiphenyl in vitro by hepatic mono-oxygenases from rat, mouse, hamster, rabbit and guinea-pig

21 January 2018

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The Primary Aromatic Amines: Their Biological Properties and Structure-Activity Relationships

21 January 2018

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Alteration of urinary levels of the carcinogen, N-hydroxy-2-naphthylamine, and its N-glucuronide in the rat by control of urinary pH, inhibition of metabolic sulfation, and changes in biliary excretion

21 January 2018

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Rapid absorption, distribution, and excretion of carcinogenic N-hydroxy-arylamines after direct urethral instillation into the rat urinary bladder.

21 January 2018

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Reaction of 1-naphthylhydroxylamine with calf thymus deoxyribonucleic acid. Isolation and synthesis of N-(guanin-C8-yl)-1-naphthylamine

21 January 2018

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DNA synthesis with methylated poly(dC-dG) templates. Evidence for a competitive nature to miscoding by

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Synthesis and properties of O6-methyldeoxyguanylic acid and its copolymers with deoxycytidylic acid

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Computer-generated graphic models of the N2-substituted deoxyguanosine adducts of 2-acetylaminofluorene and benzo[a]pyrene and the O6-substituted deoxyguanosine adduct of 1-naphthylamine in the DNA double helix

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Formation of urothelial and hepatic DNA adducts from carcinogen 2-naphthylamine

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

In vitro reaction of the carcinogen, N-hydroxy-2-naphthylamine, with DNA at the C-8 and N2 atoms of guanine and at the N6 atom of adenine

21 January 2018

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The biochemistry of aromatic amines. 10. Enzymic N-hydroxylation of arylamines and conversion of arylhydroxylamines into o-aminophenols

21 January 2018

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Carcinogenicity of benzidine, N, N″-diacetylbenzidine, and N-hydroxy-N, N'-diacetylbenzidine for female CD rats

21 January 2018

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Involvement of non-oxidative enzymes in mutagenic activation of urine from rats, given benzidine and some other aromatic amines

21 January 2018

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Benzidine revisited: a review of the literature and problems associated with the use of benzidine and its congeners

21 January 2018

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Glutathione adducts of N-methyl-4-aminoazobenzene formed in vivo and by reaction of N-benzoyloxy-N-methyl-4-aminoazobenzene with glutathione

21 January 2018

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Formation of 3-(glutathion-S-YL)-N-methyl-4-aminoazobenzene and inhibition of aminoazo dye-nucleic acid binding in vitro by reaction of glutathione with metabolically-generated N-methyl-4-aminoazobenzene-N-sulfate

21 January 2018

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Formation of N-(glutathion-S-methylene)-4-aminoazobenzene following metabolic oxidation of the N-methyl group of the carcinogen, N-methyl-4-aminoazobenzene

21 January 2018

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A comparison of the carcinogen-DNA adducts formed in rat liver in vivo after administration of single or multiple doses of N-methyl-4-aminoazobenzene

21 January 2018

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Binding of nitrosamines to cytochrome P-450 of liver microsomes

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Dimethylnitrosamine demethylation by reconstituted liver microsomal cytochrome P-450 enzyme system

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Formaldehyde damage to DNA and inhibition of DNA repair in human bronchial cells.

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Urinary excretion of dimethylnitrosamine: a quantitative relationship between dose and urinary excretion.

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Toxic liver injury; the metabolism of dimethylnitrosamine

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Dietary effects on the pharmacokinetics of three carcinogenic nitrosamines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602538409041079

Cellular injury and carcinogenesis. The effect of a protein-free high-carbohydrate diet on the metabolism of dimethylnitrosamine in the rat

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Role of dimethylnitrosamine-demethylase in the metabolic activation of dimethylnitrosamine

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Cellular injury and carcinogenesis. Inhibition of metabolism of dimethylnitrosamine by aminoacetonitrile

21 January 2018

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Preparation and template activities of polynucleotides containing O2- and O4-alkyluridine

21 January 2018

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Stability of deoxyribonucleic acid methylated in the intact animal by administration of dimethylnitrosamine. Rate of breakdown in vivo and in vitro at different dosages

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Some chemical aspects of dose-response relationships in alkylation mutagenesis

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Enzymatic release of 7-methylguanine from methylated DNA by rodent liver extracts

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Human lymphoblasts contain DNA glycosylase activity excising N-3 and N-7 methyl and ethyl purines but not O6-alkylguanines or 1-alkyladenines

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

The enzymatic release of O6-methylguanine and 3-methyladenine from DNA reacted with the carcinogen N-methyl-N-nitrosourea

21 January 2018

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Methylated purines in the deoxyribonucleic acid of various Syrian-golden-hamster tissues after administration of a hepatocarcinogenic dose of dimethylnitrosamine

21 January 2018

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Formation and subsequent removal of O6-methylguanine from deoxyribonucleic acid in rat liver and kidney after small doses of dimethylnitrosamine

21 January 2018

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Alkylation of rat liver DNA by dimethylnitrosamine: effect of dosage on O6-methylguanine levels

21 January 2018

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A system in mouse liver for the repair of O6-methylguanine lesions in methylated DNA.

21 January 2018

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Removal of O6-methylguanine from DNA by human liver fractions

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Extracts of chronic lymphocytic leukemia lymphocytes have a high level of DNA repair activity fo O6-methylguanine

21 January 2018

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Effects of carcinogens and partial hepatectomy upon the hepatic O6-methylguanine repair system in mice.

21 January 2018

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Effect of pretreatment by feeding acetylaminofluorene on methylated purines formed in rat liver DNA after administration of dimethylnitrosamine.

21 January 2018

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Enhancement of hepatic and renal tumorigenesis with thyroidectomized NZR/Gd rats treated with dimethylnitrosamine

21 January 2018

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The absorption and metabolism in rats of small oral doses of dimethylnitrosamine. Implication for the possible hazard of dimethylnitrosamine in human food

21 January 2018

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Kinetics of formation of O6-ethylguanine in, and its removal from liver DNA of rats receiving diethylnitrosamine

21 January 2018

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Formation of relatively persistent O 2 -ethylthymidine by diethylnitrosamine in rat liver DNA

21 January 2018

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DNA synthesis with methylated poly(dA-dT) templates: possible role of O4-methylthymine as a pro-mutagenic base

21 January 2018

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The carcinogenic effect of 2-oxo-propyl-propylnitrosamine in Sprague-Dawley rats.

21 January 2018

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Effect of Beta-Oxidized Nitrosamines on Syrian Hamsters. III. 2,2′-Dihydroxydi-n-propylnitrosamine2

21 January 2018

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Selective induction of pancreatic ductular tumors by single doses of N-nitrosobis(2-oxopropyl)amine in Syrian golden hamsters

21 January 2018

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Microsomal metabolism of N-nitrosodi-n-propylamine: formation of products resulting from alpha- and beta-oxidation

21 January 2018

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Urinary metabolites of N-nitrosodipropylamine, N-nitroso-2-hydroxypropylpropylamine and N-nitroso-2-oxo-propylpropylamine in the rat

21 January 2018

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[Structure of rat urinary metabolites of carcinogenic dialkylnitrosamines (author's transl)].

21 January 2018

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Alkylation of nucleic acids by N-nitrosodi-n-propyl-amine: evidence that carbonium ions are not significantly involved

21 January 2018

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Metabolism of nitrosamines in vivo. I. Evidence for -oxydation of aliphatic di-n-alkylnitrosamines: the stimultaneous formation of 7-methylguanine besides 7-propyl- or 7-butylguanine after application of di-n-propyl- or di-n-butylnitrosamine

21 January 2018

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n-Propyldiazonium ion alkylates O6 of guanine with rearrangement, but alkylates N-7 without rearrangement

21 January 2018

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The formation of N-nitrosomethyl(2-oxopropyl)amine from N-nitrosobis(2-oxopropyl)amine in vivo

21 January 2018

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Oxidative biotransformation of di-n-butylnitrosamine. Formation in vitro of aldehydes in the presence of rat liver microsomes

21 January 2018

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Monitoring N-nitrosamino acids excreted in the urine and feces of rats as an index for endogenous nitrosation

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Preferential methylation of target organ DNA by the oesophageal carcinogen N-nitrosomethylbenzylamine

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Metabolism of isomeric N-methyl-N-nitroso-(methylphenyl)-methylamines

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Change of toxicity and carcinogenicity of N-methyl-N-nitrosobenzylamine in rats by methylsubstitution in the phenylresidue

21 January 2018

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Methylation of DNA in target and non-target organs of the rat with methylbenzylnitrosamine and dimethylnitrosamine

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

DNA methylation by N-nitrosomethylbenzylamine in target and non-target tissues of NMRI mice

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Comprehensive analysis of urinary metabolites of N'-nitrosonornicotine

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Metabolic beta-hydroxylation and N-oxidation of N'-nitrosonornicotine

21 January 2018

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A Study of Tobacco Carcinogenesis. XIV. ERects of N '-Nitrosonornicotine and N '-Nitrosonanabasine in Rats 2

21 January 2018

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A study of tobacco carcinogenesis. XV. Effects of N'-nitrosonornicotine and N'-nitrosoanabasine in Syrian golden hamsters.

21 January 2018

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Metabolism of tobacco-specific N-nitrosamines by cultured human tissues

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

The detection of various nitrosamines in the hepatocyte primary culture/DNA repair test

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

The in vivo tissue disposition and in vitro target-tissue metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in Syrian golden hamsters

21 January 2018

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Carcinogenicity of the isomeric, N-nitroso-delta3-and N-nitroso-delta2-piperidines in rats and the in vivo isomerization of the delta3-to the delta2-isomer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602538409041079

Study of the carcinogenicity of large doses of dimethylnitramine, N-nitroso-L-proline, and sodium nitrite administered in drinking water to rats

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Cellular injury and carcinogenesis. Evidence for the alkylation of rat liver nucleic acids in vivo by N-nitrosomorpholine.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602538409041079

Reduction of Rat Liver Carcinogenicity of α-Nitrosomorpholine by a-Deuterium Substitution 2

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Induction of pancreatic neoplasms by 2, 2′-dioxopropyl-N-propylnitrosamine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602538409041079

Metabolism of the pancreatic carcinogens N-nitroso-bis(2-oxopropyl)amine and N-nitroso-bis(2-hydroxypropyl)amine in the Syrian hamster

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602538409041079

Carcinogenesis in Syrian hamsters by N-nitroso-2,6-dimethylmorpholine, its cis and trans isomers, and the effect of deuterium labeling

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Induction of liver cell tumours in IF mice by paracetamol

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602538409041079

Comparative metabolic studies of phenacetin and structurally-related compounds in the rat

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Neoplasia in the rat induced by N-Hydroxyphenacetin, a metabolite of phenacetin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602538409041079

Reactive metabolites of phenacetin and acetaminophen: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602538409041079

Animal Species in which N-nitroso compounds induce cancer

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Metabolism of acyclic and cyclic N-nitrosamines in cultured human bronchi

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602538409041079

N -Nitrosamines in the Rubber and Tire Industry

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602538409041079

HHE of nitrosamines in a tire manufacturing plant

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602538409041079

Snuff dipping and oral cancer among women in the southern United States

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602538409041079

Nitrogen-containing compounds in tobacco and tobacco smoke

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602538409041079

Monoclonal antibody to aflatoxin B1-modified DNA detected by enzyme immunoassay

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602538409041079

A pilot project in molecular cancer epidemiology: determination of benzo[a]pyrene — DNA adducts in animal and human tissues by immunoassays

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602538409041079

Genotoxicity of N-acetylarylamines in the Salmonella/hepatocyte system

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

Genotoxic effects of 2-acetylaminofluorene on rat and human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602538409041079

Analysis at the sequence level of mutations induced by the ultimate carcinogen N-acetoxy-N-2-acetylaminofluorene

21 January 2018

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https://api.crossref.org/works/10.3109/03602538409041079

In vitro recognition of carcinogen-induced local denaturation sites native DNA by S1 endonuclease from Aspergillus oryzae

21 January 2018

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Metabolism of Two Aromatic Amines in the Dog

21 January 2018

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Persistent Binding of Butter Yellow Metabolites to Rat Liver DNA

21 January 2018

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Mechanism of Alkylation of Nucleic Acids by Nitrosodimethylamine

21 January 2018

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Metabolism of Dimethylnitrosamine by Human Liver Slices in Vitro

21 January 2018

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Effect of dimethylnitrosamine on persistence of methylated guanines in rat liver and kidney DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602538409041079

Exhaustion and recovery of repair excision of O6-methylguanine from rat liver DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602538409041079

Renal Tumours in Rats following Injection of Dimethylnitrosamine at Birth

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602538409041079

Dimethylnitrosamine inhibits enzymatic removal of O6-methylguanine from DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.3109/03602538409041079

10.3109/03602538409041079

21 January 2018

Identifiers

DOI

1 reference

18 September 2017

1 reference