Tumor suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility (Q40169273)

18 September 2017

title

Tumor suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility (English)

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18 September 2017

Mingxuan Xia

1

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18 September 2017

Hartmut Land

series ordinal

2

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18 September 2017

language of work or name

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18 February 2007

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Nature Structural & Molecular Biology

18 September 2017

published in

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18 September 2017

volume

14

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18 September 2017

issue

3

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18 September 2017

page(s)

215-223

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Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

18 September 2017

cites work

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Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

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High-Intensity Raf Signal Causes Cell Cycle Arrest Mediated by p21Cip1

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Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21Cip1

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Rho and Rac take center stage

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Cell migration: integrating signals from front to back

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RHO-GTPases and cancer

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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

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RhoA is required for monocyte tail retraction during transendothelial migration

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The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

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Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior

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Redox-dependent downregulation of Rho by Rac.

21 January 2018

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p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho.

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Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition

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Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

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Involvement of Rho family GTPases in p19Arf- and p53-mediated proliferation of primary mouse embryonic fibroblasts

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Regulation of Cdc42-mediated morphological effects: a novel function for p53.

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Synergy between Apc min and an activated ras mutation is sufficient to induce colon carcinomas

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Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

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Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase

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Cadherin engagement inhibits RhoA via p190RhoGAP.

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p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation

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Rho GTPases control polarity, protrusion, and adhesion during cell movement

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p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling

21 January 2018

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p19ARF links the tumour suppressor p53 to Ras

21 January 2018

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Cooperating oncogenes converge to regulate cyclin/cdk complexes.

21 January 2018

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Senescence of human fibroblasts induced by oncogenic Raf.

31 March 2020

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Molecular genetics of small cell lung carcinoma

31 March 2020

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The differential effects of mutant p53 alleles on advanced murine lung cancer

31 March 2020

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Small GTP-binding protein Rho stimulates the actomyosin system, leading to invasion of tumor cells

31 March 2020

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ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility

31 March 2020

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Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-based in vitro assays

31 March 2020

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Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

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Detection of p21ras mutations in colorectal adenomas and carcinomas by enzyme-linked immunosorbent assay

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NSMB1208

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Dimensions Publication ID

18 September 2017

1039094255

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