Therapeutic window for melanoma treatment provided by selective effects of the proteasome on Bcl-2 proteins (Q40125495)

17 September 2017

title

Therapeutic window for melanoma treatment provided by selective effects of the proteasome on Bcl-2 proteins (English)

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17 September 2017

K G Wolter

1

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17 September 2017

M Verhaegen

2

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17 September 2017

Y Fernández

3

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17 September 2017

Z Nikolovska-Coleska

4

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17 September 2017

M Riblett

5

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17 September 2017

C Martin de la Vega

6

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17 September 2017

S Wang

7

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17 September 2017

M S Soengas

8

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17 September 2017

publication date

1 June 2007

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Cell Death & Differentiation

17 September 2017

published in

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17 September 2017

volume

14

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17 September 2017

issue

9

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17 September 2017

page(s)

1605-1616

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Apoptosis and melanoma chemoresistance

17 September 2017

cites work

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21 January 2018

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Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells

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Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa

21 January 2018

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Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa.

21 January 2018

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 January 2018

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

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A phase II study of bortezomib in the treatment of metastatic malignant melanoma

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Molecular sequelae of proteasome inhibition in human multiple myeloma cells

21 January 2018

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Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis.

21 January 2018

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Targeting Bcl-2 and Bcl-X with nonpeptidic small-molecule antagonists

21 January 2018

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

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A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.

21 January 2018

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Investigations on gossypol: past and present developments

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Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins

21 January 2018

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A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species.

21 January 2018

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Bcl-2 and bcl-xL antisense oligonucleotides induce apoptosis in melanoma cells of different clinical stages

21 January 2018

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21 January 2018

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21 January 2018

At the gates of death

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

21 January 2018

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

21 January 2018

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Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2

21 January 2018

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21 January 2018

Cancer statistics, 2006

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7 January 2021

Chemical blockage of the proteasome inhibitory function of bortezomib: impact on tumor cell death

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7 January 2021

Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins

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7 January 2021

Stereo-specific cytotoxic effects of gossypol enantiomers and gossypolone in tumour cell lines

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7 January 2021

Cytotoxicity of gossypol enantiomers and its quinone metabolite gossypolone in melanoma cell lines

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7 January 2021

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

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7 January 2021

Cell biology. Cellular demolition and the rules of engagement

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7 January 2021

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

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7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4402163

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Dimensions Publication ID

17 September 2017

1009408982

0 references

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