On the mechanism of reductive activation in the mode of action of some anticancer drugs (Q40104496)

17 September 2017

1 reference

title

On the mechanism of reductive activation in the mode of action of some anticancer drugs (English)

1 reference

17 September 2017

1 reference

https://api.crossref.org/works/10.1016/S0300-9084(82)80162-4

22 August 2023

author name string

V. Favaudon

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:6181817

22 August 2023

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=6181817

22 August 2023

publication date

1 July 1982

1 reference

full work available at URL

17 September 2017

https://api.elsevier.com/content/article/PII:S0300908482801624?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/S0300-9084(82)80162-4

https://api.elsevier.com/content/article/PII:S0300908482801624?httpAccept=text/plain

22 August 2023

1 reference

https://api.crossref.org/works/10.1016/S0300-9084(82)80162-4

22 August 2023

1 reference

17 September 2017

volume

64

1 reference

17 September 2017

issue

7

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17 September 2017

page(s)

457-475

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Irreversible binding of reductively activated streptonigrin to nucleic acids in the presence of metals

17 September 2017

cites work

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7 January 2021

Role of one-electron and two-electron reduction products of adriamycin and daunomycin in deoxyribonucleic acid binding

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7 January 2021

Chemistry of bleomycin. XIX. Revised structures of bleomycin and phleomycin

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7 January 2021

Binding of bleomycin to DNA: intercalation of the bithiazole rings

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7 January 2021

Bleomycin-DNA interactions: fluorescence and proton magnetic resonance studies

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7 January 2021

Copper(II).bleomycin, iron(III).bleomycin, and copper(II).phleomycin: comparative study of deoxyribonucleic acid binding

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7 January 2021

Bleomycin-A2 complexes with poly(dA-dT): A proton nuclear magnetic resonance study of the nonexchangeable hydrogens

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7 January 2021

THE CHEMISTRY OF BLEOMYCIN. IX

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7 January 2021

Action of bleomycin on DNA and RNA

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7 January 2021

Strand-scission of HeLa cell deoxyribonucleic acid by bleomycin in vitro and in vivo

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7 January 2021

The effect of bleomycin on SV40 DNA: characteristics of bleomycin action which produces a single scission in a superhelical form of SV40 DNA

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7 January 2021

Increased DNA chain breakage by combined action of bleomycin and superoxide radical

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7 January 2021

Effects of Reducing and Oxidizing Agents on the Action of Bleomycin1

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7 January 2021

A role for ferrous ion and oxygen in the degradation of DNA by bleomycin

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7 January 2021

Bleomycin-induced breakage of closed-circular DNA

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7 January 2021

DNA double-strand breaks and alkali-labile bonds produced by bleomycin

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7 January 2021

Effect of chelating agents and metal ions on the degradation of DNA by bleomycin

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7 January 2021

Properties and products of the degradation of DNA by bleomycin and iron(II)

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7 January 2021

Bleomycin-specific fragmentation of double-stranded DNA.

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7 January 2021

Specificity of DNA base release by bleomycin

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7 January 2021

Bleomycin-induced mutation and recombination in Saccharomyces cerevisiae

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7 January 2021

The redox potential of the system oxygen-superoxide

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7 January 2021

The production of hydroxyl radical by bleomycin and iron (ii)

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7 January 2021

Redox potential of iron-bleomycin

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7 January 2021

An active intermediate formed in the reaction of bleomycin-Fe(II) complex with oxygen

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7 January 2021

Enhancement of bleomycin-iron free radical damage to DNA by antioxidants and their inhibition of lipid peroxidation

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7 January 2021

Oxygen activation by cytochrome P-450.

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7 January 2021

gamma-Radiolysis of DNA in oxygenated aqueous solutions: alterations at the sugar moiety

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7 January 2021

DNA strand scission by the antitumor protein neocarzinostatin

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7 January 2021

Neocarzinostatin: Spectral characterization and separation of a non-protein chromophore

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7 January 2021

Neocarzinostatin chromophore: purification of the major active form and characterization of its spectral and biological properties

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7 January 2021

Structure of the antitumor protein neocarzinostatin. Amino acid sequence

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7 January 2021

Neocarzinostatin: chemical characterization and partial structure of the non-protein chromophore

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7 January 2021

Neocarzinostatin chromophore: presence of a cyclic carbonate subunit and its modification in the structure of other biologically active forms

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7 January 2021

Isolation of a non-protein component and a protein component from neocarzinostatin (NCS) and their biological activities

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7 January 2021

The biological effect of a nonprotein component removed from neocarzinostatin (NCS).

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7 January 2021

Subcellular action of Neocarzinostatin. Intracellular incorporation, DNA breakdown and cytotoxicity.

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7 January 2021

Requirement for reducing agents in deoxyribonucleic acid strand scisson by the purified chromophore of auromomycin

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7 January 2021

Binding of the nonprotein chromophore of neocarzinostatin to deoxyribonucleic acid

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7 January 2021

Single-strand nicking of DNA in vitro by neocarzinostatin and its possible relationship to the mechanism of drug action

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7 January 2021

Neocarzinostatin chromophore binds to deoxyribonucleic acid by intercalation

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7 January 2021

Deoxyribonucleic acid sugar damage in the action of neocarzinostatin

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7 January 2021

Strand-scission of DNA by neocarzinostatin, auromomycin, and bleomycin: studies on base release and nucleotide sequence specificity

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7 January 2021

Gaps in DNA induced by neocarzinostatin bear 3'- and 5'-phosphoryl termini

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7 January 2021

Cytotoxic and mutagenic effects of neocarzinostatin in wild-type and repair-deficient yeasts

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7 January 2021

DNA damage and repair in relation to cell killing in neocarzinostatin-treated HeLa cells

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7 January 2021

Effect of DNA repair systems on antibacterial and mutagenic activity of an antitumor protein, neocarzinostatin

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7 January 2021

Mutagenesis by neocarzinostatin in Escherichia coli and Salmonella typhimurium: requirement for umuC or plasmid pKM101

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7 January 2021

Repair of neocarzinostatin-induced deoxyribonucleic acid damage in human lymphoblastoid cells: possible involvement of apurinic/apyrimidinic sites as intermediates

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7 January 2021

Apurinic/apyrimidinic endonuclease sensitive sites as intermediates in the in vitro degradation of deoxyribonucleic acid by neocarzinostatin

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7 January 2021

Activation and inactivation of neocarzinostatin-induced cleavage of DNA

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7 January 2021

Contrasts in the actions of protein antibiotics on deoxyribonucleic acid structure and function

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7 January 2021

Nuclear protein kinase activities during the cell cycle of HeLa S3 cells

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7 January 2021

An electron spin resonance study of a spin adduct of the non-protein component (NPC) of neocarzinostatin

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7 January 2021

Electron spin resonance detection of free radicals in the mercaptan-activation and UV-inactivation of neocarzinostatin

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7 January 2021

Effects of neocarzinostatin on mammalian nuclei: release of nucleosomes

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7 January 2021

Oxidation Kinetics of 1, 5-Dihydroflavin by Oxygen in Non-aqueous Solvent

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7 January 2021

‘Daunomycin’, a New Antibiotic of the Rhodomycin Group

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7 January 2021

Synthesis of a Cyclic Hexapeptide Designated as Gramicidin J2

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7 January 2021

Reductive cleavage of anthracycline glycosides by microsomal nadphcytochrome c reductase

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7 January 2021

Variation of the supercoils in closed circular DNA by binding of antibiotics and drugs: Evidence for molecular models involving intercalation

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7 January 2021

The change of the torsion of the DNA helix caused by intercalation. II. Measurement of the relative change of torsion induced by various intercalating drugs

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7 January 2021

Strand scission of DNA by bound adriamycin and daunorubicin in the presence of reducing agents

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7 January 2021

Synthetic approaches to adriamycin. Degradation of daunorubicin to nonasymmetric tetracyclic ketone and refunctionalization of the A-ring to adriamycin

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7 January 2021

Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycin

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7 January 2021

Interactions of daunomycin and melanotropin–daunomycin with DNA

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7 January 2021

Oxygen toxicity and the superoxide dismutase

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7 January 2021

MITOMYCIN C: CHEMICAL AND BIOLOGICAL STUDIES ON ALKYLATION

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7 January 2021

MITOMYCINS AND PORFIROMYCIN: CHEMICAL MECHANISM OF ACTIVATION AND CROSS-LINKING OF DNA.

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7 January 2021

H2O2 generation during the redox cycle of mitomycin C and dna-bound mitomycin C.

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7 January 2021

The mechanism of the degradation of DNA by streptonigrin

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7 January 2021

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7 January 2021

Induction of single-strand regions in nuclear DNA by adriamycin

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7 January 2021

DNA strand scission induced by adriamycin and aclacinomycin A

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7 January 2021

Inhibition of coenzyme Q10-enzymes, succinoxidase and NADH-oxidase, by adriamycin and other quinones having antitumor activity

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7 January 2021

Daunorubicin-stimulated reactive oxygen metabolism in cardiac sarcosomes

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7 January 2021

Stimulation by adriamycin of rat heart and liver microsomal NADPH-dependent lipid peroxidation

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7 January 2021

Cellular pharmacodynamics of several anthracycline antibiotics

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7 January 2021

Reductive microbial conversion of anthracycline antibiotics

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7 January 2021

One-electron-transfer reactions in biochemical systems. 3. One-electron reduction of quinones by microsomal flavin enzymes

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7 January 2021

Adriamycin stimulated superoxide formation in submitochondrial particles

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7 January 2021

Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: Possibility for a rapid human cell mutation assay

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7 January 2021

Kinetics of flavine oxidation-reduction. I. Dismutation in nonaqueous solvent

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7 January 2021

Pulse radiolysis studies of antitumor quinones: Radical lifetimes, reactivity with oxygen, and one-electron reduction potentials

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7 January 2021

Bioactivation as a model for drug design bioreductive alkylation

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7 January 2021

Spin-trapping and direct electron spin resonance investigations of the redox metabolism of quinone anticancer drugs

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7 January 2021

Induction of DNA degradation in vivo by adriamycin

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7 January 2021

Protein-associated DNA breaks in cells treated with adriamycin or ellipticine

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7 January 2021

Qualitative and quantitative aspects of intercalator-induced DNA strand breaks

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7 January 2021

DNA crosslinking induced by x-rays and chemical agents

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7 January 2021

DNA-protein cross-linking by ultraviolet radiation in normal human and xeroderma pigmentosum fibroblasts

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7 January 2021

Biochemical analysis of damage induced in yeast by formaldehyde. II. Induction of cross-links between DNA and protein

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7 January 2021

Induction of single strand scission in bacteriophage phi X174 replicative form I DNA by mitomycin C

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7 January 2021

Bioactivation of the antitumor drugs 9-hydroxyellipticine and derivatives by a peroxidase-hydrogen peroxide system

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7 January 2021

The interaction of adriamycin with nuclear DNA: evidence for a drug induced compaction of isolated chromatin

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7 January 2021

Binding mode of chemically activated semiquinone free radicals from quinone anticancer agents to DNA

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7 January 2021

DNA double-strand breaks in mammalian cells after exposure to intercalating agents

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7 January 2021

Evidence for a functional oxygen-bound intermediate in the reaction of Escherichia coli cytochrome o with oxygen

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7 January 2021

Binding of daunomycin to nonhistone proteins from rat liver

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7 January 2021

The relationship between DNA strand-scission and DNA synthesis inhibition in HeLa cells treated with neocarzinostatin

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7 January 2021

Interaction of antitumor drugs with human erythrocyte ghost membranes and mastocytoma P815: A spin label study

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7 January 2021

Reductive metabolism and alkylating activity of mitomycin C induced by rat liver microsomes

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7 January 2021

Protein-associated deoxyribonucleic acid strand breaks in L1210 cells treated with the deoxyribonucleic acid intercalating agents 4'-(9-acridinylamino) methanesulfon-m-anisidide and adriamycin

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7 January 2021

The effect of physiological levels of divalent metal ions on the interaction of daunomycin with DNA: evidence of a ternary daunomycin-Cu2 -DNA complex

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7 January 2021

Superoxide radicals and hydrogen peroxide formation in mitochondria from normal and neoplastic tissues

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7 January 2021

Production of superoxide anions and hydrogen peroxide in Ehrlich ascites tumour cell nuclei

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7 January 2021

Superoxide dismutase and glutathione peroxidase activities in tumors

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7 January 2021

A protective effect of coenzyme Q10 on the adriamycin-induced cardiotoxicity in the isolated perfused rat heart

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7 January 2021

Biological activity of the antitumor protein neocarzinostatin coupled to a monoclonal antibody by N-succinimidyl 3-(2-pyridyldithio)-propionate

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7 January 2021

Mechanism of adriamycin cardiotoxicity: evidence for oxidative stress

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7 January 2021

Inhibition by adriamycin of calmodulin-sensitive and phospholipid-sensitive calcium-dependent phosphorylation of endogenous proteins from heart

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7 January 2021

The cardiotoxic antibiotic doxorubicin inhibits the Na /Ca2 exchange of dog heart sarcolemmal vesicles

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7 January 2021

Enhanced antitumor properties of 3'-(4-morpholinyl) and 3'-(4-methoxy-1-piperidinyl) derivatives of 3'-deaminodaunorubicin

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7 January 2021

Adriamycin analogues. Preparation and antitumor evaluation of 7-O-(beta-D-glucosaminyl)daunomycinone and 7-O-(beta-D-glucosaminyl)adriamycinone and their N-trifluoroacetyl derivatives

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7 January 2021

Adriamycin analogues. Novel anomeric ribofuranoside analogues of daunorubicin

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7 January 2021

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86

39

3768

Müller

1979

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22 August 2023

87

38

2617

Ishida

1978

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22 August 2023

105

41

1006

Levin

1981

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22 August 2023

Molecular Pharmacology

107

13

901

Bachur

1977

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22 August 2023

Molecular Pharmacology

109

4

549

White

1968

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161

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5103

Galvan

1981

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Physiological chemistry and physics

22 August 2023

166

6

95

Yamanaka

1974

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180

41

2745

Krishan

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17 September 2017

1 reference